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Minhang Xin - Publications

Affiliations: 
2017 Georgia State University, Atlanta, GA, United States 
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bai H, Yang Z, Lei H, Wu Y, Liu J, Yuan B, Ma M, Gao L, Zhang SQ, Xin M. Discovery of novel pyrrolo[2,3-d]pyrimidines as potent menin-mixed lineage leukemia interaction inhibitors. European Journal of Medicinal Chemistry. 268: 116226. PMID 38367493 DOI: 10.1016/j.ejmech.2024.116226  0.404
2023 Xi XX, Zhao HY, Mao YZ, Xin M, Zhang SQ. Modification of osimertinib to discover new potent EGFR-TK inhibitors. European Journal of Medicinal Chemistry. 261: 115865. PMID 37839342 DOI: 10.1016/j.ejmech.2023.115865  0.388
2023 Bai H, Sun J, Lei H, Zhang SQ, Yuan B, Ma M, Xin M. Discovery of novel pyrido[3,2-d]pyrimidine derivatives as selective and potent PI3Kδ inhibitors. Drug Development Research. PMID 37732677 DOI: 10.1002/ddr.22114  0.483
2023 Gao L, Chuai H, Ma M, Zhang SQ, Zhang J, Li J, Wang Y, Xin M. Design, synthesis and bioactivity evaluation of selenium-containing PI3Kδ inhibitors. Bioorganic Chemistry. 140: 106815. PMID 37672953 DOI: 10.1016/j.bioorg.2023.106815  0.494
2023 Ma M, Feng Y, Zhang SQ, Duan W, Gao L, Yuan B, Xin M. Design, synthesis and biological evaluation of novel selective PI3Kδ inhibitors containing pyridopyrimidine scaffold. Future Medicinal Chemistry. PMID 37565336 DOI: 10.4155/fmc-2023-0149  0.46
2023 Lei H, Duan W, Zhang SQ, Feng Y, Ma M, Yuan B, Xin M. Discovery of potent and selective PI3Kδ inhibitors bearing amino acid fragments. Bioorganic Chemistry. 138: 106594. PMID 37186998 DOI: 10.1016/j.bioorg.2023.106594  0.378
2022 Lei H, Zhang SQ, Bai H, Zhao HY, Sun J, Chuai H, Xin M. Discovery of Novel, Potent, and Selective Small-Molecule Menin-Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups. Journal of Medicinal Chemistry. PMID 36173787 DOI: 10.1021/acs.jmedchem.2c01313  0.326
2021 Chuai H, Zhang SQ, Bai H, Li J, Wang Y, Sun J, Wen E, Zhang J, Xin M. Small molecule selenium-containing compounds: Recent development and therapeutic applications. European Journal of Medicinal Chemistry. 223: 113621. PMID 34217061 DOI: 10.1016/j.ejmech.2021.113621  0.335
2020 Yang XY, Zhao HY, Lei H, Yuan B, Mao S, Xin M, Zhang SQ. Synthesis and biological evaluation of 10-substituted camptothecin derivatives with improved water solubility and activity. Chemmedchem. PMID 33241878 DOI: 10.1002/cmdc.202000753  0.311
2020 Xin M, Sun J, Huang W, Tang F, Liu Z, Jin Q, Wang J. Design and synthesis of novel phthalazinone derivatives as potent poly(ADP-ribose)polymerase 1 inhibitors. Future Medicinal Chemistry. PMID 33012191 DOI: 10.4155/fmc-2020-0009  0.469
2020 Zhao HY, Yang XY, Lei H, Xi XX, Lu SM, Zhang JJ, Xin M, Zhang SQ. Discovery of potent small molecule PROTACs targeting mutant EGFR. European Journal of Medicinal Chemistry. 208: 112781. PMID 32883633 DOI: 10.1016/J.Ejmech.2020.112781  0.487
2020 Sun J, Feng Y, Huang Y, Zhang SQ, Xin M. Research Advances on Selective Phosphatidylinositol 3 Kinase δ (PI3Kδ) Inhibitors. Bioorganic & Medicinal Chemistry Letters. 127457. PMID 32755681 DOI: 10.1016/J.Bmcl.2020.127457  0.445
2020 Zhang H, Zhao HY, Xi XX, Liu YJ, Xin M, Mao S, Zhang JJ, Lu AX, Zhang SQ. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). European Journal of Medicinal Chemistry. 189: 112061. PMID 31951960 DOI: 10.1016/J.Ejmech.2020.112061  0.383
2020 Xin M, Wang H, Zhang H, Shen Y, Zhang S. Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors Journal of Chemical Research. 44: 393-402. DOI: 10.1177/1747519820904844  0.524
2019 Lei H, Fan S, Zhang H, Liu YJ, Hei YY, Zhang JJ, Zheng AQ, Xin M, Zhang SQ. Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors. European Journal of Medicinal Chemistry. 111888. PMID 31787359 DOI: 10.1016/J.Ejmech.2019.111888  0.488
2019 Feng Y, Cu X, Xin M. PI3Kδ inhibitors for the treatment of cancer: a patent review (2015-present). Expert Opinion On Therapeutic Patents. PMID 31670985 DOI: 10.1080/13543776.2019.1687685  0.429
2019 Feng Y, Duan W, Fan S, Zhang H, Zhang SQ, Xin M. Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors. Bioorganic & Medicinal Chemistry. 115035. PMID 31434616 DOI: 10.1016/J.Bmc.2019.07.051  0.47
2019 Hei YY, Zhang SQ, Feng Y, Wang J, Duan W, Zhang H, Mao S, Sun H, Xin M. Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors. Bioorganic & Medicinal Chemistry. PMID 31176568 DOI: 10.1016/J.Bmc.2019.05.043  0.452
2019 Wang Y, Huang W, Xin M, Chen P, Gui L, Zhao X, Zhu X, Luo H, Cong X, Wang J, Liu F. Discovery of potent anti-inflammatory 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl) pyrimidin-2-amines for use as Janus kinase inhibitors. Bioorganic & Medicinal Chemistry. PMID 30926315 DOI: 10.1016/J.Bmc.2019.03.048  0.528
2019 Zhao H, Yang X, Lei H, Xin M, Zhang S. Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study Synthetic Communications. 49: 1406-1415. DOI: 10.1080/00397911.2019.1598558  0.315
2018 Mao S, Chen Z, Wang L, Khadka DB, Xin M, Li P, Zhang SQ. Synthesis of Aryl Trimethylstannane via BF3·OEt2-mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature. The Journal of Organic Chemistry. PMID 30540911 DOI: 10.1021/Acs.Joc.8B02766  0.31
2018 Wang HY, Shen Y, Zhang H, Hei YY, Zhao HY, Xin M, Lu SM, Zhang SQ. Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor. Future Medicinal Chemistry. PMID 30325235 DOI: 10.4155/Fmc-2018-0145  0.476
2018 Xin M, Zhang L, Tu C, Tang F, Wen J. Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry. PMID 30249494 DOI: 10.1016/J.Bmc.2018.08.037  0.57
2018 Zhang H, Wang J, Zhao HY, Yang XY, Lei H, Xin M, Cao YX, Zhang SQ. Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry. PMID 29853340 DOI: 10.1016/J.Bmc.2018.05.039  0.496
2018 Liang C, Tian D, Ren X, Ding S, Jia M, Xin M, Thareja S. The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review. European Journal of Medicinal Chemistry. 151: 315-326. PMID 29631132 DOI: 10.1016/J.Ejmech.2018.03.062  0.453
2018 Hei YY, Shen Y, Wang J, Zhang H, Zhao HY, Xin M, Cao YX, Li Y, Zhang SQ. Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors. Bioorganic & Medicinal Chemistry. PMID 29576272 DOI: 10.1016/J.Bmc.2018.03.025  0.541
2018 Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 33: 651-656. PMID 29536777 DOI: 10.1080/14756366.2018.1444608  0.524
2018 Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors. Bioorganic & Medicinal Chemistry. PMID 29534936 DOI: 10.1016/J.Bmc.2018.03.002  0.572
2018 Zhang H, Wang J, Shen Y, Wang HY, Duan WM, Zhao HY, Hei YY, Xin M, Cao YX, Zhang SQ. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. European Journal of Medicinal Chemistry. 148: 221-237. PMID 29466773 DOI: 10.1016/J.Ejmech.2018.02.051  0.459
2018 Xin M, Ji X, De La Cruz LK, Thareja S, Wang B. Strategies to target the Hedgehog signaling pathway for cancer therapy. Medicinal Research Reviews. PMID 29315702 DOI: 10.1002/Med.21482  0.567
2017 Zhao HY, Wang HY, Mao S, Xin M, Zhang H, Zhang SQ. Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp(2) C-H bond amination mediated by cupric acetate. Organic & Biomolecular Chemistry. PMID 28752166 DOI: 10.1039/C7Ob01353A  0.321
2017 Xin M, Zhang L, Wen J, Shen H, Zhao X, Jin Q, Tang F. Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino)benzamides leading to a series of potent hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28642101 DOI: 10.1016/J.Bmcl.2017.06.030  0.571
2017 Xin M, Hei YY, Zhang H, Shen Y, Zhang SQ. Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28325601 DOI: 10.1016/J.Bmcl.2017.03.020  0.513
2016 Wang Y, Huang W, Xin M, Chen P, Gui L, Zhao X, Tang F, Wang J, Liu F. Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors. Bioorganic & Medicinal Chemistry. PMID 27771180 DOI: 10.1016/J.Bmc.2016.10.011  0.512
2016 Hei YY, Xin M, Zhang H, Xie XX, Mao S, Zhang SQ. Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27544401 DOI: 10.1016/J.Bmcl.2016.08.015  0.511
2016 Xin M, Zhang L, Wen J, Shen H, Liu Z, Zhao X, Jin Q, Wang M, Cheng L, Huang W, Tang F. Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry. PMID 26827136 DOI: 10.1016/J.Bmc.2016.01.034  0.553
2016 Xin M, Zhang L, Jin Q, Tang F, Wen J, Gu L, Cheng L, Zhao Y. Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors. European Journal of Medicinal Chemistry. 110: 115-125. PMID 26820554 DOI: 10.1016/J.Ejmech.2016.01.018  0.548
2016 Xin M, Hei Y, Zhang H, Xie X, Mao S, Zuo S, Zhang S. Discovery of 6-benzamide Containing 4-phenylquinazoline Derivatives as Novel PI3Kδ Inhibitors Letters in Drug Design & Discovery. 14: 167-174. DOI: 10.2174/1570180813666160720160523  0.501
2015 Zhang H, Xin MH, Xie XX, Mao S, Zuo SJ, Lu SM, Zhang SQ. Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety. Bioorganic & Medicinal Chemistry. PMID 26652969 DOI: 10.1016/J.Bmc.2015.11.027  0.549
2015 Xin M, Zhao X, Huang W, Jin Q, Wu G, Wang Y, Tang F, Xiang H. Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry. 23: 6250-7. PMID 26344595 DOI: 10.1016/J.Bmc.2015.08.039  0.555
2015 Xie XX, Li H, Wang J, Mao S, Xin MH, Lu SM, Mei QB, Zhang SQ. Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity. Bioorganic & Medicinal Chemistry. PMID 26321603 DOI: 10.1016/J.Bmc.2015.08.013  0.531
2015 Zhao X, Xin M, Wang Y, Huang W, Jin Q, Tang F, Wu G, Zhao Y, Xiang H. Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry. PMID 26277759 DOI: 10.1016/J.Bmc.2015.05.043  0.56
2015 Wang XM, Mao S, Cao L, Xie XX, Xin MH, Lian JF, Cao YX, Zhang SQ. Modification of N-(6-(2-methoxy-3-(4-fluorophenylsulfonamido)pyridin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide as PI3Ks inhibitor by replacement of the acetamide group with alkylurea. Bioorganic & Medicinal Chemistry. PMID 26210161 DOI: 10.1016/J.Bmc.2015.07.017  0.529
2015 Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H. Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. 23: 4344-4353. PMID 26169764 DOI: 10.1016/J.Bmc.2015.06.023  0.516
2015 Wang XM, Xin MH, Xu J, Kang BR, Li Y, Lu SM, Zhang SQ. Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo. European Journal of Medicinal Chemistry. 96: 382-95. PMID 25911625 DOI: 10.1016/J.Ejmech.2015.04.037  0.463
2015 Wang XM, Xu J, Xin MH, Lu SM, Zhang SQ. Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro. Bioorganic & Medicinal Chemistry Letters. 25: 1730-5. PMID 25765909 DOI: 10.1016/J.Bmcl.2015.02.067  0.422
2015 Xin M. Hedgehog inhibitors: a patent review (2013 - present). Expert Opinion On Therapeutic Patents. 25: 549-65. PMID 25726713 DOI: 10.1517/13543776.2015.1019864  0.434
2015 Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H. Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry. 23: 891-901. PMID 25596757 DOI: 10.1016/J.Bmc.2014.10.043  0.521
2015 Zhao X, Xin M, Huang W, Ren Y, Jin Q, Tang F, Jiang H, Wang Y, Yang J, Mo S, Xiang H. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. 23: 348-64. PMID 25515957 DOI: 10.1016/J.Bmc.2014.11.006  0.571
2015 Xin M, Zhao X, Huang W, Jin Q, Wu G, Wang Y, Tang F, Xiang H. Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2015.08.039  0.395
2014 Zhang L, Xin M, Shen H, Wen J, Tang F, Tu C, Zhao X, Wei P. Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. Bioorganic & Medicinal Chemistry Letters. 24: 3486-92. PMID 24923765 DOI: 10.1016/J.Bmcl.2014.05.066  0.524
2014 Xin M, Zhang L, Tang F, Tu C, Wen J, Zhao X, Liu Z, Cheng L, Shen H. Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry. 22: 1429-40. PMID 24486203 DOI: 10.1016/J.Bmc.2013.12.055  0.557
2014 Xin M, Wen J, Tang F, Tu C, Huang W, Shen H, Zhao X, Cheng L, Wang M, Zhang L. Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway. Bioorganic & Medicinal Chemistry Letters. 24: 983-8. PMID 24405704 DOI: 10.1016/J.Bmcl.2013.12.050  0.568
2014 Xin M, Zhang L, Shen H, Wen J, Tu C, Liu Z, Cheng L, Zhao X. Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d] pyrimidine derivatives as novel hedgehog signaling pathway inhibitors Medicinal Chemistry Research. 23: 3784-3792. DOI: 10.1007/S00044-014-0959-3  0.559
2013 Xin M, Wen J, Tang F, Tu C, Shen H, Zhao X. The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6777-83. PMID 24176396 DOI: 10.1016/J.Bmcl.2013.10.022  0.56
2013 Xin M, Gao Y, Xiang H, Chen D, He Y, You Q. A General and Facile Synthesis of Novel Polysubstituted Quinazolin-4(3H)-ones Journal of Heterocyclic Chemistry. 50: 169-174. DOI: 10.1002/Jhet.1001  0.328
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