☰

Mei-Jung Lai - Publications

Affiliations: 
2010 College of Pharmacy Taipei Medical University 
Tree Info Similar researchers PubMed Report error

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sharma R, Chiang YH, Chen HC, Lin HY, Yang WB, Nepali K, Lai MJ, Chen KY, Liou JP, Hsu TI. Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress. Cancer Letters. 216666. PMID 38311053 DOI: 10.1016/j.canlet.2024.216666  0.64
2024 Sharma S, Wang SA, Yang WB, Lin HY, Lai MJ, Chen HC, Kao TY, Hsu FL, Nepali K, Hsu TI, Liou JP. First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity and . Journal of Medicinal Chemistry. PMID 38285511 DOI: 10.1021/acs.jmedchem.3c02053  0.653
2023 Tsai FL, Huang HL, Lai MJ, Liou JP, Pan SL, Yang CR. Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells. International Journal of Molecular Sciences. 24. PMID 37628767 DOI: 10.3390/ijms241612588  0.64
2023 Narwanti I, Yu ZY, Sethy B, Lai MJ, Lee HY, Olena P, Lee SB, Liou JP. 6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers. European Journal of Medicinal Chemistry. 258: 115505. PMID 37302341 DOI: 10.1016/j.ejmech.2023.115505  0.646
2023 Tseng HJ, Banerjee S, Qian B, Lai MJ, Wu TY, Hsu TI, Lin TE, Hsu KC, Chuang KH, Liou JP, Shih JC. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. European Journal of Medicinal Chemistry. 256: 115459. PMID 37172473 DOI: 10.1016/j.ejmech.2023.115459  0.66
2023 Lai MJ, Lee HY, Chuang HY, Chang LH, Tsai AC, Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou JP. Correction to "-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling". Journal of Medicinal Chemistry. PMID 37079573 DOI: 10.1021/acs.jmedchem.3c00574  0.674
2023 Nepali K, Wu AC, Lo WL, Chopra B, Lai MJ, Chuang JY, Liou JP. Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects. European Journal of Medicinal Chemistry. 248: 115054. PMID 36630883 DOI: 10.1016/j.ejmech.2022.115054  0.661
2021 Hsu TJ, Nepali K, Tsai CH, Imtiyaz Z, Lin FL, Hsiao G, Lai MJ, Cheng YW. The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production. Molecules (Basel, Switzerland). 26. PMID 34299636 DOI: 10.3390/molecules26144359  0.319
2021 Liu YM, Tu HJ, Wu CH, Lai MJ, Yu SC, Chao MW, Wu YW, Teng CM, Pan SL, Liou JP. Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo. European Journal of Medicinal Chemistry. 219: 113428. PMID 33934008 DOI: 10.1016/j.ejmech.2021.113428  0.687
2021 Nepali K, Hsu TI, Hsieh CM, Lo WL, Lai MJ, Hsu KC, Lin TE, Chuang JY, Liou JP. Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma. European Journal of Medicinal Chemistry. 217: 113338. PMID 33744690 DOI: 10.1016/j.ejmech.2021.113338  0.652
2021 Singh A, Chang TY, Kaur N, Hsu KC, Yen Y, Lin TE, Lai MJ, Lee SB, Liou JP. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition. European Journal of Medicinal Chemistry. 215: 113169. PMID 33588178 DOI: 10.1016/j.ejmech.2021.113169  0.663
2021 Mehndiratta S, Chen MC, Chao YH, Lee CH, Liou JP, Lai MJ, Lee HY. Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 74-84. PMID 33161799 DOI: 10.1080/14756366.2020.1839446  0.675
2020 Liu YM, HuangFu WC, Huang HL, Wu WC, Chen YL, Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL, Liou JP. Corrigendum to "1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma" [Eur. J. Med. Chem. 140 (2017) 84-91]. European Journal of Medicinal Chemistry. 202: 112633. PMID 32688164 DOI: 10.1016/J.Ejmech.2020.112633  0.748
2020 Wu WC, Liu YM, Liao YH, Hsu KC, Lien ST, Chen IC, Lai MJ, Li YH, Pan SL, Chen MC, Liou JP. Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells. European Journal of Medicinal Chemistry. 203: 112540. PMID 32683166 DOI: 10.1016/J.Ejmech.2020.112540  0.709
2020 Ojha R, Nepali K, Chen CH, Chuang KH, Wu TY, Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP. Corrigendum to"Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo"[Eur. J. Med. Chem. 190 (2020 Mar 15) 112086]. European Journal of Medicinal Chemistry. 201: 112404. PMID 32526554 DOI: 10.1016/J.Ejmech.2020.112404  0.776
2020 Fang YC, Chan L, Liou JP, Tu YK, Lai MJ, Chen CI, Vidyanti AN, Lee HY, Hu CJ. HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen-glucose deprivation injuries via H3K14 and H4K5 acetylation-mediated BDNF expression. Journal of Cellular and Molecular Medicine. PMID 32374084 DOI: 10.1111/Jcmm.15358  0.6
2020 Nepali K, Chang TY, Lai MJ, Hsu KC, Yen Y, Lin TE, Lee SB, Liou JP. Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors. European Journal of Medicinal Chemistry. 196: 112291. PMID 32325365 DOI: 10.1016/j.ejmech.2020.112291  0.674
2020 Wu WC, Liu YM, Lin MH, Liao YH, Lai MJ, Chuang HY, Hung TY, Chen CH, Liou JP. Corrigendum to "Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response" [Eur J Med Chem. 192 2020 112158]. European Journal of Medicinal Chemistry. 196: 112329. PMID 32311605 DOI: 10.1016/j.ejmech.2020.112329  0.717
2020 Wu WC, Liu YM, Lin MH, Liao YH, Lai MJ, Chuang HY, Hung TY, Chen CH, Liou JP. Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response. European Journal of Medicinal Chemistry. 192: 112158. PMID 32171161 DOI: 10.1016/j.ejmech.2020.112158  0.742
2020 Ojha R, Nepali K, Chen CH, Chuang KH, Wu TY, Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. European Journal of Medicinal Chemistry. 190: 112086. PMID 32058238 DOI: 10.1016/J.Ejmech.2020.112086  0.821
2019 Kaur N, Fang YC, Lee HY, Singh A, Nepali K, Lin MH, Yeh TK, Lai MJ, Chan L, Tu YK, Banerjee S, Hu CJ, Liou JP. Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry. 187: 111915. PMID 31838329 DOI: 10.1016/j.ejmech.2019.111915  0.513
2019 Nepali K, Lin MH, Chao MW, Peng SJ, Hsu KC, Eight Lin T, Chen MC, Lai MJ, Pan SL, Liou JP. Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells. Bioorganic Chemistry. 91: 103119. PMID 31349117 DOI: 10.1016/j.bioorg.2019.103119  0.655
2019 Chao MW, Chang LH, Tu HJ, Chang CD, Lai MJ, Chen YY, Liou JP, Teng CM, Pan SL. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status. Clinical Epigenetics. 11: 85. PMID 31142371 DOI: 10.1186/s13148-019-0681-6  0.562
2018 Lai MJ, Ojha R, Lin MH, Liu YM, Lee HY, Lin TE, Hsu KC, Chang CY, Chen MC, Nepali K, Chang JY, Liou JP. 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. European Journal of Medicinal Chemistry. 162: 612-630. PMID 30476825 DOI: 10.1016/J.Ejmech.2018.10.066  0.812
2018 Lee HY, Fan SJ, Huang FI, Chao HY, Hsu KC, Lin TE, Yeh TK, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP. 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes. Journal of Medicinal Chemistry. PMID 30028616 DOI: 10.1021/acs.jmedchem.8b00151  0.62
2018 Ojha R, Huang HL, HuangFu WC, Wu YW, Nepali K, Lai MJ, Su CJ, Sung TY, Chen YL, Pan SL, Liou JP. 1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC. European Journal of Medicinal Chemistry. 150: 667-677. PMID 29567459 DOI: 10.1016/J.Ejmech.2018.03.006  0.818
2018 Lee HY, Nepali K, Huang FI, Chang CY, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP. (N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in vitro and in Vivo. Journal of Medicinal Chemistry. PMID 29304284 DOI: 10.1021/acs.jmedchem.7b01404  0.71
2017 Liu YM, HuangFu WC, Huang HL, Wu WC, Chen YL, Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL, Liou JP. 1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma. European Journal of Medicinal Chemistry. 140: 84-91. PMID 28923389 DOI: 10.1016/j.ejmech.2017.09.011  0.777
2017 Chao MW, Huang HL, HuangFu WC, Hsu KC, Liu YM, Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. Oncotarget. PMID 28186963 DOI: 10.18632/oncotarget.15115  0.594
2016 Nepali K, Lee HY, Lai MJ, Ojha R, Wu TY, Wu GX, Chen MC, Liou JP. Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms. European Journal of Medicinal Chemistry. 127: 115-127. PMID 28038324 DOI: 10.1016/J.Ejmech.2016.12.039  0.825
2016 Lee HY, Lee JF, Kumar S, Wu YW, HuangFu WC, Lai MJ, Li YH, Huang HL, Kuo FC, Hsiao CJ, Cheng CC, Yang CR, Liou JP. 3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity. European Journal of Medicinal Chemistry. 125: 1268-1278. PMID 27886544 DOI: 10.1016/J.Ejmech.2016.11.033  0.736
2015 Chen MC, Huang HH, Lai CY, Lin YJ, Liou JP, Lai MJ, Li YH, Teng CM, Yang CR. Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma. Oncotarget. PMID 26587975 DOI: 10.18632/Oncotarget.6352  0.65
2015 Liu YM, Lee HY, Lai MJ, Pan SL, Huang HL, Kuo FC, Chen MC, Liou JP. Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. Organic & Biomolecular Chemistry. PMID 26309122 DOI: 10.1039/C5Ob01509J  0.739
2015 Lai MJ, Lee HY, Chuang HY, Chang LH, Tsai AC, Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou JP. N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling. Journal of Medicinal Chemistry. PMID 26241032 DOI: 10.1021/Acs.Jmedchem.5B00659  0.785
2015 Lee HY, Chang CY, Lai MJ, Chuang HY, Kuo CC, Chang CY, Chang JY, Liou JP. Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes. Bioorganic & Medicinal Chemistry. 23: 4230-6. PMID 26160020 DOI: 10.1016/j.bmc.2015.06.043  0.763
2015 Chao MW, Lai MJ, Liou JP, Chang YL, Wang JC, Pan SL, Teng CM. The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo. Journal of Hematology & Oncology. 8: 82. PMID 26156322 DOI: 10.1186/S13045-015-0176-7  0.619
2015 Huang HL, Peng CY, Lai MJ, Chen CH, Lee HY, Wang JC, Liou JP, Pan SL, Teng CM. Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Oncotarget. 6: 4976-91. PMID 25669976 DOI: 10.18632/Oncotarget.3213  0.7
2015 Liu YM, Lee HY, Chen CH, Lee CH, Wang LT, Pan SL, Lai MJ, Yeh TK, Liou JP. 1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells. European Journal of Medicinal Chemistry. 89: 320-30. PMID 25462248 DOI: 10.1016/J.Ejmech.2014.10.052  0.696
2014 Wang CY, Liou JP, Tsai AC, Lai MJ, Liu YM, Lee HY, Wang JC, Pan SL, Teng CM. A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression. Oncotarget. 5: 9838-50. PMID 25226613 DOI: 10.18632/Oncotarget.2451  0.648
2014 Mehndiratta S, Chiang YF, Lai MJ, Lee HY, Chen MC, Kuo CC, Chang CY, Chang JY, Liou JP. Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents. Bioorganic & Medicinal Chemistry. 22: 4917-23. PMID 25059503 DOI: 10.1016/J.Bmc.2014.06.042  0.725
2014 Hsieh IN, Liou JP, Lee HY, Lai MJ, Li YH, Yang CR. Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009. Cell Death & Disease. 5: e1166. PMID 24722291 DOI: 10.1038/Cddis.2014.133  0.644
2013 Lee HY, Pan SL, Su MC, Liu YM, Kuo CC, Chang YT, Wu JS, Nien CY, Mehndiratta S, Chang CY, Wu SY, Lai MJ, Chang JY, Liou JP. Furanylazaindoles: potent anticancer agents in vitro and in vivo. Journal of Medicinal Chemistry. 56: 8008-18. PMID 24106982 DOI: 10.1021/jm4011115  0.801
2013 Lee HY, Yang CR, Lai MJ, Huang HL, Hsieh YL, Liu YM, Yeh TK, Li YH, Mehndiratta S, Teng CM, Liou JP. 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors. Chembiochem : a European Journal of Chemical Biology. 14: 1248-54. PMID 23788254 DOI: 10.1002/Cbic.201300201  0.678
2013 Lee HY, Yang CR, Lai MJ, Huang HL, Hsieh YL, Liu YM, Yeh TK, Li YH, Mehndiratta S, Teng CM, Liou JP. Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013) Chembiochem. 14: 1150-1150. DOI: 10.1002/Cbic.201390034  0.628
2012 Huang HL, Huang HL, Lee HY, Tsai AC, Peng CY, Lai MJ, Wang JC, Pan SL, Teng CM, Liou JP. Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo. Plos One. 7: e43645. PMID 22928010 DOI: 10.1371/Journal.Pone.0043645  0.715
2012 Lai MJ, Huang HL, Pan SL, Liu YM, Peng CY, Lee HY, Yeh TK, Huang PH, Teng CM, Chen CS, Chuang HY, Liou JP. Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. Journal of Medicinal Chemistry. 55: 3777-91. PMID 22439863 DOI: 10.1021/jm300197a  0.792
2011 Lai MJ, Chang JY, Lee HY, Kuo CC, Lin MH, Hsieh HP, Chang CY, Wu JS, Wu SY, Shey KS, Liou JP. Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents. European Journal of Medicinal Chemistry. 46: 3623-9. PMID 21641700 DOI: 10.1016/J.Ejmech.2011.04.065  0.695
2011 Lee HY, Chang JY, Chang LY, Lai WY, Lai MJ, Shih KH, Kuo CC, Chang CY, Liou JP. Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation. Organic & Biomolecular Chemistry. 9: 3154-7. PMID 21416070 DOI: 10.1039/C0Ob01038C  0.638
2011 Chuang HY, Chang JY, Lai MJ, Kuo CC, Lee HY, Hsieh HP, Chen YJ, Chen LT, Pan WY, Liou JP. 2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors. Chemmedchem. 6: 450-6. PMID 21360819 DOI: 10.1002/cmdc.201000479  0.767
2009 Lai MJ, Kuo CC, Yeh TK, Hsieh HP, Chen LT, Pan WY, Hsu KY, Chang JY, Liou JP. Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents. Chemmedchem. 4: 588-93. PMID 19266513 DOI: 10.1002/cmdc.200800405  0.637
2008 Reddy GR, Kuo CC, Tan UK, Coumar MS, Chang CY, Chiang YK, Lai MJ, Yeh JY, Wu SY, Chang JY, Liou JP, Hsieh HP. Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents. Journal of Medicinal Chemistry. 51: 8163-7. PMID 19053773 DOI: 10.1021/Jm8008635  0.695
Show low-probability matches.