| Year |
Citation |
Score |
| 2022 |
Abd Elghani F, Safory H, Hamza H, Savyon M, Farhoud M, Toren-Hershoviz M, Vitic Z, Ebanks K, Shani V, Bisharat S, Shaulov L, Brodski C, Song Z, Bandopadhyay R, Engelender S. SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease. Aging Cell. e13731. PMID 36307912 DOI: 10.1111/acel.13731 |
0.359 |
|
| 2022 |
Engelender S, Stefanis L, Oddo S, Bellucci A. Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35579450 DOI: 10.1002/mds.29058 |
0.366 |
|
| 2020 |
Vitic Z, Safory H, Jovanovic VM, Sarusi Y, Stavsky A, Kahn J, Kuzmina A, Toker L, Gitler D, Taube R, Friedel RH, Engelender S, Brodski C. BMP5/7 protect dopaminergic neurons in an α -synuclein mouse model of Parkinson's disease. Brain : a Journal of Neurology. PMID 33253359 DOI: 10.1093/brain/awaa368 |
0.312 |
|
| 2020 |
Savyon M, Engelender S. SUMOylation in α-Synuclein Homeostasis and Pathology. Frontiers in Aging Neuroscience. 12: 167. PMID 32670048 DOI: 10.3389/Fnagi.2020.00167 |
0.477 |
|
| 2019 |
Shani V, Safory H, Szargel R, Wang N, Cohen T, Elghani FA, Hamza H, Savyon M, Radzishevsky I, Shaulov L, Rott R, Lim KL, Ross CA, Bandopadhyay R, Zhang H, ... Engelender S, et al. Physiological and pathological roles of LRRK2 in the nuclear envelope integrity. Human Molecular Genetics. PMID 31626293 DOI: 10.1093/Hmg/Ddz245 |
0.587 |
|
| 2019 |
Hallett PJ, Engelender S, Isacson O. Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease. Journal of Neuroinflammation. 16: 153. PMID 31331333 DOI: 10.1186/S12974-019-1532-2 |
0.427 |
|
| 2017 |
Rott R, Szargel R, Shani V, Hamza H, Savyon M, Abd Elghani F, Bandopadhyay R, Engelender S. SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation. Proceedings of the National Academy of Sciences of the United States of America. 114: 13176-13181. PMID 29180403 DOI: 10.1073/Pnas.1704351114 |
0.406 |
|
| 2017 |
Basil AH, Sim JPL, Lim GGY, Lin S, Chan HY, Engelender S, Lim KL. AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease. Frontiers in Cellular Neuroscience. 11: 241. PMID 28848400 DOI: 10.3389/Fncel.2017.00241 |
0.464 |
|
| 2017 |
Vicente Miranda H, Szego ÉM, Oliveira LM, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, ... ... Engelender S, et al. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain : a Journal of Neurology. PMID 28398476 DOI: 10.1093/Brain/Awx056 |
0.4 |
|
| 2016 |
Engelender S, Isacson O. The Threshold Theory for Parkinson's Disease. Trends in Neurosciences. PMID 27894611 DOI: 10.1016/J.Tins.2016.10.008 |
0.428 |
|
| 2016 |
Szargel R, Shani V, Abd Elghani F, Mekies LN, Liani E, Rott R, Engelender S. The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway. Human Molecular Genetics. 25: 3476-3490. PMID 27334109 DOI: 10.1093/Hmg/Ddw189 |
0.387 |
|
| 2016 |
Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/Ncomms11792 |
0.577 |
|
| 2016 |
Liu J, Li T, Thomas JM, Pei Z, Jiang H, Engelender S, Ross CA, Smith WW. Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models. Human Molecular Genetics. PMID 26744328 DOI: 10.1093/Hmg/Ddv504 |
0.583 |
|
| 2014 |
Rott R, Szargel R, Shani V, Bisharat S, Engelender S. α-Synuclein ubiquitination and novel therapeutic targets for Parkinson's disease. Cns & Neurological Disorders Drug Targets. 13: 630-7. PMID 24168368 DOI: 10.2174/18715273113126660195 |
0.447 |
|
| 2013 |
Abeywardana T, Lin YH, Rott R, Engelender S, Pratt MR. Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein. Chemistry & Biology. 20: 1207-13. PMID 24210006 DOI: 10.1016/J.Chembiol.2013.09.009 |
0.4 |
|
| 2013 |
Haskin J, Szargel R, Shani V, Mekies LN, Rott R, Lim GG, Lim KL, Bandopadhyay R, Wolosker H, Engelender S. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease. Human Molecular Genetics. 22: 2083-96. PMID 23393160 DOI: 10.1093/Hmg/Ddt058 |
0.433 |
|
| 2012 |
Engelender S. α-Synuclein fate: proteasome or autophagy? Autophagy. 8: 418-20. PMID 22361583 DOI: 10.4161/Auto.19085 |
0.398 |
|
| 2011 |
Rott R, Szargel R, Haskin J, Bandopadhyay R, Lees AJ, Shani V, Engelender S. α-Synuclein fate is determined by USP9X-regulated monoubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 108: 18666-71. PMID 22065755 DOI: 10.1073/Pnas.1105725108 |
0.405 |
|
| 2010 |
Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, ... Engelender S, et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics. 11: 203-15. PMID 19730898 DOI: 10.1007/S10048-009-0215-Z |
0.543 |
|
| 2009 |
Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S. Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation. The Journal of Biological Chemistry. 284: 11706-16. PMID 19224863 DOI: 10.1074/Jbc.M805990200 |
0.443 |
|
| 2008 |
Engelender S. Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease. Autophagy. 4: 372-4. PMID 18216494 DOI: 10.4161/Auto.5604 |
0.491 |
|
| 2008 |
Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S. Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. The Journal of Biological Chemistry. 283: 3316-28. PMID 18070888 DOI: 10.1074/Jbc.M704809200 |
0.419 |
|
| 2008 |
Szargel R, Rott R, Engelender S. Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation. Cellular and Molecular Life Sciences : Cmls. 65: 80-8. PMID 17982729 DOI: 10.1007/S00018-007-7343-0 |
0.521 |
|
| 2007 |
Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, et al. The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1759-67. PMID 17327361 DOI: 10.1096/Fj.06-6734Com |
0.514 |
|
| 2007 |
Avraham E, Rott R, Liani E, Szargel R, Engelender S. Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. The Journal of Biological Chemistry. 282: 12842-50. PMID 17327227 DOI: 10.1074/Jbc.M608243200 |
0.402 |
|
| 2006 |
Eyal A, Engelender S. Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease. Cell Cycle (Georgetown, Tex.). 5: 2082-6. PMID 16969096 DOI: 10.4161/Cc.5.18.3209 |
0.47 |
|
| 2006 |
Franck T, Krueger R, Woitalla D, Müller T, Engelender S, Riess O. Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 1903-8. PMID 16752048 DOI: 10.1007/S00702-006-0480-Z |
0.504 |
|
| 2006 |
Eyal A, Szargel R, Avraham E, Liani E, Haskin J, Rott R, Engelender S. Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients. Proceedings of the National Academy of Sciences of the United States of America. 103: 5917-22. PMID 16595633 DOI: 10.1073/Pnas.0509707103 |
0.432 |
|
| 2005 |
Avraham E, Szargel R, Eyal A, Rott R, Engelender S. Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation. The Journal of Biological Chemistry. 280: 42877-86. PMID 16174773 DOI: 10.1074/Jbc.M505608200 |
0.433 |
|
| 2005 |
Bandopadhyay R, Kingsbury AE, Muqit MM, Harvey K, Reid AR, Kilford L, Engelender S, Schlossmacher MG, Wood NW, Latchman DS, Harvey RJ, Lees AJ. Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition Neurobiology of Disease. 20: 401-411. PMID 15894486 DOI: 10.1016/J.Nbd.2005.03.021 |
0.506 |
|
| 2005 |
Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2002-9. PMID 15728840 DOI: 10.1523/Jneurosci.4474-04.2005 |
0.583 |
|
| 2004 |
Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S. Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 5500-5. PMID 15064394 DOI: 10.1073/Pnas.0401081101 |
0.644 |
|
| 2003 |
Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schöls L, Schulz JB, et al. Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease. Human Molecular Genetics. 12: 1223-31. PMID 12761037 DOI: 10.1093/Hmg/Ddg134 |
0.609 |
|
| 2003 |
Igarashi S, Morita H, Bennett KM, Tanaka Y, Engelender S, Peters MF, Cooper JK, Wood JD, Sawa A, Ross CA. Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation. Neuroreport. 14: 565-8. PMID 12657886 DOI: 10.1097/00001756-200303240-00007 |
0.495 |
|
| 2002 |
Ribeiro CS, Carneiro K, Ross CA, Menezes JR, Engelender S. Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein. The Journal of Biological Chemistry. 277: 23927-33. PMID 11956199 DOI: 10.1074/Jbc.M201115200 |
0.56 |
|
| 2002 |
Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H. Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathologica. 103: 209-14. PMID 11907799 DOI: 10.1007/S004010100451 |
0.59 |
|
| 2001 |
Bandopadhyay R, de Silva R, Khan N, Graham E, Vaughan J, Engelender S, Ross C, Morris H, Morris C, Wood NW, Daniel S, Lees A. No pathogenic mutations in the synphilin-1 gene in Parkinson's disease. Neuroscience Letters. 307: 125-7. PMID 11427316 DOI: 10.1016/S0304-3940(01)01935-8 |
0.579 |
|
| 2001 |
Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human Molecular Genetics. 10: 919-26. PMID 11309365 DOI: 10.1093/Hmg/10.9.919 |
0.61 |
|
| 2001 |
Farrer M, Destée A, Levecque C, Singleton A, Engelender S, Becquet E, Mouroux V, Richard F, Defebvre L, Crook R, Hernandez D, Ross CA, Hardy J, Amouyel P, Chartier-Harlin MC. Genetic analysis of synphilin-1 in familial Parkinson's disease. Neurobiology of Disease. 8: 317-23. PMID 11300726 DOI: 10.1006/Nbdi.2000.0326 |
0.584 |
|
| 2000 |
Nasir J, Lafuente MJ, Duan K, Colomer V, Engelender S, Ingersoll R, Margolis RL, Ross CA, Hayden MR. Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism. Gene. 254: 181-7. PMID 10974549 DOI: 10.1016/S0378-1119(00)00269-9 |
0.484 |
|
| 2000 |
Engelender S, Wanner T, Kleiderlein JJ, Wakabayashi K, Tsuji S, Takahashi H, Ashworth R, Margolis RL, Ross CA. Organization of the human synphilin-1 gene, a candidate for Parkinson's disease. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 763-6. PMID 10967135 DOI: 10.1007/S003350010123 |
0.64 |
|
| 2000 |
ENGELENDER S, SANTORO A. Synphilin-1: a possible molecular determinant for Parkinson's disease Anais Da Academia Brasileira De CiêNcias. 72: 439-439. DOI: 10.1590/S0001-37652000000300027 |
0.395 |
|
| 2000 |
Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H. Synphilin-1 is present in Lewy bodies in Parkinson's disease Annals of Neurology. 47: 521-523. DOI: 10.1002/1531-8249(200004)47:4<521::Aid-Ana18>3.0.Co;2-B |
0.6 |
|
| 1999 |
Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nature Genetics. 22: 110-4. PMID 10319874 DOI: 10.1038/8820 |
0.636 |
|
| 1999 |
Nasir J, Maclean A, Engelender S, Duan K, Margolis RL, Kleiderlein JJ, Ross CA, Hayden MR. Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 397-8. PMID 10087300 DOI: 10.1007/S003359901009 |
0.445 |
|
| 1998 |
Ross CA, Margolis RL, Becher MW, Wood JD, Engelender S, Cooper JK, Sharp AH. Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions. Progress in Brain Research. 117: 397-419. PMID 9932422 DOI: 10.1016/S0079-6123(08)64029-7 |
0.576 |
|
| 1998 |
Nasir J, Duan K, Nichol K, Engelender S, Ashworth R, Colomer V, Thomas S, Disteche CM, Hayden MR, Ross CA. Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 565-70. PMID 9657855 DOI: 10.1007/S003359900819 |
0.534 |
|
| 1997 |
Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Human Molecular Genetics. 6: 2205-12. PMID 9361024 DOI: 10.1093/Hmg/6.13.2205 |
0.529 |
|
| 1997 |
Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Human Molecular Genetics. 6: 1519-25. PMID 9285789 DOI: 10.1093/Hmg/6.9.1519 |
0.52 |
|
| 1997 |
Ross CA, Becher MW, Colomer V, Engelender S, Wood JD, Sharp AH. Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology. Brain Pathology (Zurich, Switzerland). 7: 1003-16. PMID 9217980 DOI: 10.1111/J.1750-3639.1997.Tb00898.X |
0.559 |
|
| 1994 |
Engelender S, Rumjanek FD. Protein-DNA associations in a gender-specific gene of Schistosoma mansoni: characterization by UV cross-linking, DNase I footprinting and band shift assays. Memorias Do Instituto Oswaldo Cruz. 67-70. PMID 1343927 DOI: 10.1590/S0074-02761992000800008 |
0.312 |
|
| 1993 |
Engelender S, Giannini AL, Rumjanek FD. Protein interactions with a gender-specific gene of Schistosoma mansoni: characterization by DNase I footprinting, band shift and UV cross-linking. Molecular and Cellular Biochemistry. 124: 159-68. PMID 7901756 DOI: 10.1007/Bf00929208 |
0.302 |
|
| Show low-probability matches. |