| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2024 | Creus-Muncunill J, Haure-Mirande JV, Mattei D, Bons J, Ramirez AV, Hamilton BW, Corwin C, Chowdhury S, Schilling B, Ellerby LM, Ehrlich ME. TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration. Journal of Neuroinflammation. 21: 66. PMID 38459557 DOI: 10.1186/s12974-024-03052-4 | 0.327 | |||
| 2024 | Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser AA, Lan J, ... ... Ellerby LM, et al. OXR1 maintains the retromer to delay brain aging under dietary restriction. Nature Communications. 15: 467. PMID 38212606 DOI: 10.1038/s41467-023-44343-3 | 0.554 | |||
| 2023 | Kapahi P, Bar S, Wilson K, Hilsabeck T, Alderfer S, Dammer E, Burton J, Shah S, Holtz A, Carrera E, Beck J, Chen J, Kauwe G, Tracy T, Seyfried N, ... ... Ellerby L, et al. Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction. Research Square. PMID 37986935 DOI: 10.21203/rs.3.rs-3526342/v1 | 0.576 | |||
| 2021 | Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, ... ... Ellerby LM, et al. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 1-22. PMID 34024231 DOI: 10.1080/15548627.2021.1904489 | 0.335 | |||
| 2020 | García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, ... ... Ellerby LM, et al. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathologica. PMID 32642868 DOI: 10.1007/S00401-020-02183-1 | 0.421 | |||
| 2019 | Naphade S, Tshilenge KT, Ellerby LM. Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 16: 979-998. PMID 31792895 DOI: 10.1007/S13311-019-00810-8 | 0.405 | |||
| 2019 | Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. Elife. 8. PMID 30994454 DOI: 10.7554/Elife.42988 | 0.322 | |||
| 2019 | Ellerby LM. Decision letter: Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls Elife. DOI: 10.7554/Elife.50333.Sa1 | 0.315 | |||
| 2017 | Naphade S, Embusch A, Madushani KL, Ring KL, Ellerby LM. Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease. Frontiers in Neuroscience. 11: 736. PMID 29459817 DOI: 10.3389/Fnins.2017.00736 | 0.331 | |||
| 2017 | Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, ... ... Ellerby LM, et al. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533375 DOI: 10.1073/Pnas.1614943114 | 0.359 | |||
| 2016 | Voisin J, Farina F, Lejeune F, Ellerby LM, Neri C. B19 RNAseq and chipseq analysis of FOXO3 targets in an huntington’s disease human neural stem cell model Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-314597.50 | 0.39 | |||
| 2015 | Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports. 5: 1023-1038. PMID 26651603 DOI: 10.1016/J.Stemcr.2015.11.005 | 0.388 | |||
| 2015 | Zhang N, Bailus BJ, Ring KL, Ellerby LM. iPSC-based drug screening for Huntington׳s disease. Brain Research. PMID 26428226 DOI: 10.1016/J.Brainres.2015.09.020 | 0.368 | |||
| 2015 | Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature Medicine. PMID 26390242 DOI: 10.1038/Nm.3951 | 0.331 | |||
| 2015 | O'Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM. Integration Independent Transgenic Huntington's Disease Fragment Mouse Models Reveal Distinct Phenotypes and Lifespan In Vivo. The Journal of Biological Chemistry. PMID 26025364 DOI: 10.1074/Jbc.M114.623561 | 0.369 | |||
| 2015 | Guyenet SJ, Mookerjee SS, Lin A, Custer SK, Chen SF, Sopher BL, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Human Molecular Genetics. 24: 3908-17. PMID 25859008 DOI: 10.1093/Hmg/Ddv121 | 0.419 | |||
| 2014 | An MC, O'Brien RN, Zhang N, Patra BN, De La Cruz M, Ray A, Ellerby LM. Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System. Plos Currents. 6. PMID 24761311 DOI: 10.1371/Currents.Hd.0242D2E7Ad72225Efa72F6964589369A | 0.328 | |||
| 2014 | An M, Zhang N, Ring K, O’Brien R, Melov S, Mooney S, Coppola G, Ellerby LM. UNDERSTANDING THE PATHWAYS THAT LEAD TO NERVE CELL DEATH IN HUNTINGTON’S DISEASE Free Radical Biology and Medicine. 76: S3. DOI: 10.1016/J.Freeradbiomed.2014.10.014 | 0.314 | |||
| 2013 | Duncan CE, An MC, Papanikolaou T, Rugani C, Vitelli C, Ellerby LM. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Molecular Neurodegeneration. 8: 42. PMID 24160175 DOI: 10.1186/1750-1326-8-42 | 0.346 | |||
| 2012 | Sarantos MR, Papanikolaou T, Ellerby LM, Hughes RE. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. Journal of Huntington's Disease. 1: 195-210. PMID 23393546 DOI: 10.3233/Jhd-120033 | 0.392 | |||
| 2012 | Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Plos Genetics. 8: e1003042. PMID 23209424 DOI: 10.1371/Journal.Pgen.1003042 | 0.404 | |||
| 2012 | Zou Y, Zhang N, Ellerby LM, Davalos AR, Zeng X, Campisi J, Desprez PY. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. Biochemical and Biophysical Research Communications. 426: 100-5. PMID 22917535 DOI: 10.1016/J.Bbrc.2012.08.043 | 0.345 | |||
| 2012 | An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell. 11: 253-63. PMID 22748967 DOI: 10.1016/J.Stem.2012.04.026 | 0.409 | |||
| 2012 | Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, ... ... Ellerby LM, et al. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7454-65. PMID 22649225 DOI: 10.1523/Jneurosci.6379-11.2012 | 0.44 | |||
| 2012 | Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. The Journal of Biological Chemistry. 287: 21204-13. PMID 22511757 DOI: 10.1074/Jbc.M111.321661 | 0.415 | |||
| 2011 | Cong X, Held JM, DeGiacomo F, Bonner A, Chen JM, Schilling B, Czerwieniec GA, Gibson BW, Ellerby LM. Mass spectrometric identification of novel lysine acetylation sites in huntingtin. Molecular & Cellular Proteomics : McP. 10: M111.009829. PMID 21685499 DOI: 10.1074/Mcp.M111.009829 | 0.36 | |||
| 2010 | Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chemistry & Biology. 17: 1189-200. PMID 21095569 DOI: 10.1016/J.Chembiol.2010.08.014 | 0.43 | |||
| 2010 | Zhang N, An MC, Montoro D, Ellerby LM. Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells. Plos Currents. 2: RRN1193. PMID 21037797 DOI: 10.1371/Currents.Rrn1193 | 0.41 | |||
| 2010 | Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 67: 199-212. PMID 20670829 DOI: 10.1016/J.Neuron.2010.06.021 | 0.359 | |||
| 2010 | Duncan C, Papanikolaou T, Ellerby LM. Autophagy: polyQ toxic fragment turnover. Autophagy. 6: 312-4. PMID 20104018 DOI: 10.4161/Auto.6.2.11139 | 0.424 | |||
| 2010 | Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, Sun B, Gafni J, Ellerby LM, Trottier Y, Richards WG, Osmand A, Paganetti P, Bates GP. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. The Journal of Biological Chemistry. 285: 8808-23. PMID 20086007 DOI: 10.1074/Jbc.M109.075028 | 0.428 | |||
| 2009 | Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15134-44. PMID 19955365 DOI: 10.1523/Jneurosci.4720-09.2009 | 0.429 | |||
| 2009 | Papanikolaou T, Ellerby LM. IGF-1: elixir for motor neuron diseases. Neuron. 63: 277-8. PMID 19679066 DOI: 10.1016/J.Neuron.2009.07.024 | 0.319 | |||
| 2009 | Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM. Calpain-1 cleaves and activates caspase-7. The Journal of Biological Chemistry. 284: 25441-9. PMID 19617626 DOI: 10.1074/Jbc.M109.038174 | 0.337 | |||
| 2009 | Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1987-97. PMID 19228953 DOI: 10.1523/Jneurosci.4072-08.2009 | 0.44 | |||
| 2007 | Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. The Journal of Biological Chemistry. 282: 30150-60. PMID 17646170 DOI: 10.1074/Jbc.M705265200 | 0.432 | |||
| 2007 | Khan AA, Sun Y, Jin K, Mao XO, Chen S, Ellerby LM, Greenberg DA. A neuroglobin-overexpressing transgenic mouse. Gene. 398: 172-6. PMID 17537594 DOI: 10.1016/J.Gene.2007.02.044 | 0.364 | |||
| 2007 | Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, ... ... Ellerby LM, et al. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Plos Genetics. 3: e82. PMID 17500595 DOI: 10.1371/Journal.Pgen.0030082 | 0.341 | |||
| 2007 | Oliveira JM, Jekabsons MB, Chen S, Lin A, Rego AC, Gonçalves J, Ellerby LM, Nicholls DG. Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. Journal of Neurochemistry. 101: 241-9. PMID 17394466 DOI: 10.1111/J.1471-4159.2006.04361.X | 0.347 | |||
| 2006 | Khan AA, Wang Y, Sun Y, Mao XO, Xie L, Miles E, Graboski J, Chen S, Ellerby LM, Jin K, Greenberg DA. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proceedings of the National Academy of Sciences of the United States of America. 103: 17944-8. PMID 17098866 DOI: 10.1073/Pnas.0607497103 | 0.31 | |||
| 2006 | Oliveira JM, Chen S, Almeida S, Riley R, Gonçalves J, Oliveira CR, Hayden MR, Nicholls DG, Ellerby LM, Rego AC. Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11174-86. PMID 17065457 DOI: 10.1523/Jneurosci.3004-06.2006 | 0.345 | |||
| 2006 | Ellerby LM, Orr HT. Neurodegenerative disease: cut to the chase. Nature. 442: 641-2. PMID 16900190 DOI: 10.1038/442641A | 0.355 | |||
| 2006 | Schilling B, Gafni J, Torcassi C, Cong X, Row RH, LaFevre-Bernt MA, Cusack MP, Ratovitski T, Hirschhorn R, Ross CA, Gibson BW, Ellerby LM. Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity. The Journal of Biological Chemistry. 281: 23686-97. PMID 16782707 DOI: 10.1074/Jbc.M513507200 | 0.34 | |||
| 2006 | Taylor J, Grote SK, Xia J, Vandelft M, Graczyk J, Ellerby LM, La Spada AR, Truant R. Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. The Journal of Biological Chemistry. 281: 2730-9. PMID 16314424 DOI: 10.1074/Jbc.M506751200 | 0.377 | |||
| 2006 | Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease. 21: 381-91. PMID 16150600 DOI: 10.1016/J.Nbd.2005.07.014 | 0.424 | |||
| 2005 | Jin K, LaFevre-Bernt M, Sun Y, Chen S, Gafni J, Crippen D, Logvinova A, Ross CA, Greenberg DA, Ellerby LM. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 18189-94. PMID 16326808 DOI: 10.1073/Pnas.0506375102 | 0.413 | |||
| 2005 | Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, Kopito RR. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proceedings of the National Academy of Sciences of the United States of America. 102: 13135-40. PMID 16141322 DOI: 10.1073/Pnas.0505801102 | 0.383 | |||
| 2004 | Berke SJ, Schmied FA, Brunt ER, Ellerby LM, Paulson HL. Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3. Journal of Neurochemistry. 89: 908-18. PMID 15140190 DOI: 10.1111/J.1471-4159.2004.02369.X | 0.448 | |||
| 2004 | Sopher BL, Thomas PS, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin LW, Libby RT, Ellerby LM, La Spada AR. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 41: 687-99. PMID 15003169 DOI: 10.1016/S0896-6273(04)00082-0 | 0.341 | |||
| 2004 | Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. The Journal of Biological Chemistry. 279: 20211-20. PMID 14981075 DOI: 10.1074/Jbc.M401267200 | 0.438 | |||
| 2004 | Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, ... ... Ellerby LM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/Sj.Cdd.4401358 | 0.445 | |||
| 2003 | LaFevre-Bernt MA, Ellerby LM. Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death. The Journal of Biological Chemistry. 278: 34918-24. PMID 12824190 DOI: 10.1074/Jbc.M302841200 | 0.356 | |||
| 2003 | Wellington CL, Ellerby LM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Huntington proteolysis in Huntington disease Clinical Neuroscience Research. 3: 129-139. DOI: 10.1016/S1566-2772(03)00055-0 | 0.452 | |||
| 2002 | Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, et al. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7862-72. PMID 12223539 DOI: 10.1523/Jneurosci.22-18-07862.2002 | 0.441 | |||
| 2002 | Gafni J, Ellerby LM. Calpain activation in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4842-9. PMID 12077181 DOI: 10.1523/Jneurosci.22-12-04842.2002 | 0.399 | |||
| 2002 | Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. Febs Letters. 514: 122-8. PMID 11943137 DOI: 10.1016/S0014-5793(02)02289-5 | 0.341 | |||
| 2002 | Ellerby LM. Hunting for excitement: NMDA receptors in Huntington's disease. Neuron. 33: 841-2. PMID 11906690 DOI: 10.1016/S0896-6273(02)00631-1 | 0.373 | |||
| 2001 | Lee M, Hyun DH, Marshall KA, Ellerby LM, Bredesen DE, Jenner P, Halliwell B. Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radical Biology & Medicine. 31: 1550-9. PMID 11744329 DOI: 10.1016/S0891-5849(01)00633-5 | 0.317 | |||
| 2001 | Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby LM, Bredesen DE. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Human Molecular Genetics. 10: 1531-8. PMID 11468270 DOI: 10.1093/Hmg/10.15.1531 | 0.369 | |||
| 2000 | Rabizadeh S, Ye X, Sperandio S, Wang JJL, Ellerby HM, Ellerby LM, Giza C, Andrusiak RL, Frankowski H, Yaron Y, Moayeri NN, Rovelli G, Evans CJ, Butcher LL, Nolan GP, et al. Neurotrophin dependence domain: A domain required for the mediation of apoptosis by the p75 neurotrophin receptor Journal of Molecular Neuroscience. 15: 215-229. PMID 11303785 DOI: 10.1385/Jmn:15:3:215 | 0.316 | |||
| 2000 | Cafe C, Testa MP, Sheldon PJ, French WP, Ellerby LM, Bredesen DE. Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants. Journal of Molecular Neuroscience. 15: 71-83. PMID 11220787 DOI: 10.1385/Jmn:15:2:71 | 0.355 | |||
| 2000 | Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. The Journal of Biological Chemistry. 275: 19831-8. PMID 10770929 DOI: 10.1074/Jbc.M001475200 | 0.336 | |||
| 1999 | Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia Proceedings of the National Academy of Sciences of the United States of America. 96: 5752-5757. PMID 10318956 DOI: 10.1073/Pnas.96.10.5752 | 0.374 | |||
| 1999 | Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. The Journal of Biological Chemistry. 274: 8730-6. PMID 10085113 DOI: 10.1074/Jbc.274.13.8730 | 0.314 | |||
| 1999 | Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. Journal of Neurochemistry. 72: 185-95. PMID 9886069 DOI: 10.1046/J.1471-4159.1999.0720185.X | 0.312 | |||
| 1998 | Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria Proceedings of the National Academy of Sciences of the United States of America. 95: 4997-5002. PMID 9560217 DOI: 10.1073/Pnas.95.9.4997 | 0.334 | |||
| 1996 | Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 12240-4. PMID 8901564 DOI: 10.1073/Pnas.93.22.12240 | 0.312 | |||
| 1996 | Bredesen DE, Wiedau-Pazos M, Goto JJ, Rabizadeh S, Roe JA, Gralla EB, Ellerby LM, Valentine JS. Cell death mechanisms in ALS. Neurology. 47: S36-8; discussion S3. PMID 8858049 DOI: 10.1212/Wnl.47.4_Suppl_2.36S | 0.321 | |||
| 1993 | Tamai KT, Gralla EB, Ellerby LM, Valentine JS, Thiele DJ. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 90: 8013-7. PMID 8367458 DOI: 10.1073/Pnas.90.17.8013 | 0.307 | |||
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