| Year |
Citation |
Score |
| 2021 |
Gomez-Escribano JP, Algora Gallardo L, Bozhüyük KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B. Genome editing reveals that pSCL4 is required for chromosome linearity in . Microbial Genomics. 7. PMID 34747689 DOI: 10.1099/mgen.0.000669 |
0.668 |
|
| 2019 |
Bozhüyük KA, Micklefield J, Wilkinson B. Engineering enzymatic assembly lines to produce new antibiotics. Current Opinion in Microbiology. 51: 88-96. PMID 31743841 DOI: 10.1016/J.Mib.2019.10.007 |
0.692 |
|
| 2019 |
Vikeli E, Widdick DA, Batey SF, Heine D, Holmes NA, Bibb MJ, Martins DJ, Pierce NE, Hutchings MI, Wilkinson B. activation and heterologous production of a cryptic lantibiotic from a plant-ant derived species. Applied and Environmental Microbiology. PMID 31732571 DOI: 10.1128/AEM.01876-19 |
0.311 |
|
| 2018 |
Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B. Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nature Communications. 9: 2208. PMID 29880868 DOI: 10.1038/S41467-018-04520-1 |
0.425 |
|
| 2017 |
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, ... ... Wilkinson B, et al. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. Nature Communications. 8: 1206. PMID 29089518 DOI: 10.1038/S41467-017-01344-3 |
0.575 |
|
| 2015 |
Law BJC, Struck AW, Bennett MR, Wilkinson B, Micklefield J. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase. Chemical Science. 6: 2885-2892. PMID 29403635 DOI: 10.1039/C5Sc00164A |
0.69 |
|
| 2015 |
Alt S, Wilkinson B. Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin. Acs Chemical Biology. 10: 2468-79. PMID 26349074 DOI: 10.1021/acschembio.5b00525 |
0.326 |
|
| 2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Wilkinson B, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.708 |
|
| 2015 |
Schäfer M, Le TB, Hearnshaw SJ, Maxwell A, Challis GL, Wilkinson B, Buttner MJ. SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone. Journal of Molecular Biology. 427: 2192-204. PMID 25861759 DOI: 10.1016/J.Jmb.2015.03.019 |
0.303 |
|
| 2012 |
Wu MC, Law B, Wilkinson B, Micklefield J. Bioengineering natural product biosynthetic pathways for therapeutic applications. Current Opinion in Biotechnology. 23: 931-40. PMID 22487048 DOI: 10.1016/J.Copbio.2012.03.008 |
0.715 |
|
| 2011 |
Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, ... ... Wilkinson B, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science (Royal Society of Chemistry : 2010). 2011: 273-278. PMID 22822423 DOI: 10.1039/C0Sc00297F |
0.706 |
|
| 2011 |
Qu X, Jiang N, Xu F, Shao L, Tang G, Wilkinson B, Liu W. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. Molecular Biosystems. 7: 852-61. PMID 21416665 DOI: 10.1039/C0Mb00234H |
0.336 |
|
| 2011 |
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, ... ... Wilkinson B, et al. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proceedings of the National Academy of Sciences of the United States of America. 108: 4776-81. PMID 21383123 DOI: 10.1073/Pnas.1015773108 |
0.559 |
|
| 2009 |
Wilkinson B, Micklefield J. Chapter 14. Biosynthesis of nonribosomal peptide precursors. Methods in Enzymology. 458: 353-78. PMID 19374990 DOI: 10.1016/S0076-6879(09)04814-9 |
0.691 |
|
| 2008 |
Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S. Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. Organic & Biomolecular Chemistry. 6: 3315-27. PMID 18802638 DOI: 10.1039/B807914E |
0.506 |
|
| 2008 |
Petkovi? H, Sandmann A, Challis IR, Hecht HJ, Silakowski B, Low L, Beeston N, Kuscer E, Garcia-Bernardo J, Leadlay PF, Kendrew SG, Wilkinson B, Müller R. Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase. Organic & Biomolecular Chemistry. 6: 500-6. PMID 18219420 DOI: 10.1039/B714804F |
0.598 |
|
| 2007 |
Powell A, Borg M, Amir-Heidari B, Neary JM, Thirlway J, Wilkinson B, Smith CP, Micklefield J. Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains. Journal of the American Chemical Society. 129: 15182-91. PMID 18020333 DOI: 10.1021/Ja074331O |
0.713 |
|
| 2007 |
Powell A, Al Nakeeb M, Wilkinson B, Micklefield J. Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. Chemical Communications (Cambridge, England). 2683-5. PMID 17594019 DOI: 10.1039/B706224A |
0.668 |
|
| 2007 |
Wilkinson B, Micklefield J. Mining and engineering natural-product biosynthetic pathways. Nature Chemical Biology. 3: 379-86. PMID 17576425 DOI: 10.1038/Nchembio.2007.7 |
0.72 |
|
| 2007 |
Kuscer E, Coates N, Challis I, Gregory M, Wilkinson B, Sheridan R, Petković H. Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. Journal of Bacteriology. 189: 4756-63. PMID 17468238 DOI: 10.1128/JB.00129-07 |
0.315 |
|
| 2007 |
Neary JM, Powell A, Gordon L, Milne C, Flett F, Wilkinson B, Smith CP, Micklefield J. An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics. Microbiology (Reading, England). 153: 768-76. PMID 17322197 DOI: 10.1099/Mic.0.2006/002725-0 |
0.718 |
|
| 2006 |
Sheehan LS, Lill RE, Wilkinson B, Sheridan RM, Vousden WA, Kaja AL, Crouse GD, Gifford J, Graupner PR, Karr L, Lewer P, Sparks TC, Leadlay PF, Waldron C, Martin CJ. Engineering of the spinosyn PKS: directing starter unit incorporation. Journal of Natural Products. 69: 1702-10. PMID 17190446 DOI: 10.1021/Np0602517 |
0.524 |
|
| 2006 |
Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, ... Wilkinson B, et al. Rapamycin biosynthesis: Elucidation of gene product function. Organic & Biomolecular Chemistry. 4: 3565-8. PMID 16990929 DOI: 10.1039/B608813A |
0.511 |
|
| 2006 |
Wilkinson B, Gregory MA, Moss SJ, Carletti I, Sheridan RM, Kaja A, Ward M, Olano C, Mendez C, Salas JA, Leadlay PF, vanGinckel R, Zhang MQ. Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorganic & Medicinal Chemistry Letters. 16: 5814-7. PMID 16962775 DOI: 10.1016/J.Bmcl.2006.08.073 |
0.478 |
|
| 2006 |
Moss SJ, Carletti I, Olano C, Sheridan RM, Ward M, Math V, Nur-E-Alam M, Braña AF, Zhang MQ, Leadlay PF, Méndez C, Salas JA, Wilkinson B. Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. Chemical Communications (Cambridge, England). 2341-3. PMID 16733573 DOI: 10.1039/B602931K |
0.471 |
|
| 2005 |
Gregory MA, Petkovic H, Lill RE, Moss SJ, Wilkinson B, Gaisser S, Leadlay PF, Sheridan RM. Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angewandte Chemie (International Ed. in English). 44: 4757-60. PMID 15977283 DOI: 10.1002/Anie.200462784 |
0.482 |
|
| 2004 |
Olano C, Moss SJ, Braña AF, Sheridan RM, Math V, Weston AJ, Méndez C, Leadlay PF, Wilkinson B, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Molecular Microbiology. 52: 1745-56. PMID 15186422 DOI: 10.1111/J.1365-2958.2004.04090.X |
0.556 |
|
| 2004 |
Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus. Angewandte Chemie (International Ed. in English). 43: 2551-3. PMID 15127450 DOI: 10.1002/Anie.200453764 |
0.58 |
|
| 2004 |
Olano C, Wilkinson B, Sánchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Braña AF, Martin CJ, Oliynyk M, Méndez C, Leadlay PF, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chemistry & Biology. 11: 87-97. PMID 15112998 DOI: 10.1016/J.Chembiol.2003.12.018 |
0.549 |
|
| 2003 |
Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Organic & Biomolecular Chemistry. 1: 4144-7. PMID 14685317 DOI: 10.1039/B310740J |
0.635 |
|
| 2003 |
Olano C, Wilkinson B, Moss SJ, Braña AF, Méndez C, Leadlay PF, Salas JA. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chemical Communications (Cambridge, England). 2780-2. PMID 14651102 DOI: 10.1039/B310648A |
0.476 |
|
| 2003 |
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Organic & Biomolecular Chemistry. 1: 2840-7. PMID 12968333 DOI: 10.1039/B304022D |
0.607 |
|
| 2003 |
Petkovic H, Lill RE, Sheridan RM, Wilkinson B, McCormick EL, McArthur HA, Staunton J, Leadlay PF, Kendrew SG. A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase. The Journal of Antibiotics. 56: 543-51. PMID 12931864 DOI: 10.7164/Antibiotics.56.543 |
0.613 |
|
| 2003 |
Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Active-site residue, domain and module swaps in modular polyketide synthases. Journal of Industrial Microbiology & Biotechnology. 30: 489-94. PMID 12811585 DOI: 10.1007/S10295-003-0062-0 |
0.61 |
|
| 2002 |
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J. Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chemistry & Biology. 9: 1175-87. PMID 12445768 DOI: 10.1016/S1074-5521(02)00252-1 |
0.723 |
|
| 2002 |
Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, Staunton J. Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chemical Communications (Cambridge, England). 618-9. PMID 12120151 DOI: 10.1039/B200536K |
0.586 |
|
| 2001 |
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.). Angewandte Chemie (International Ed. in English). 40: 777-779. PMID 11241621 DOI: 10.1002/1521-3773(20010216)40:4<777::Aid-Anie7770>3.0.Co;2-9 |
0.625 |
|
| 1997 |
Staunton J, Wilkinson B. Biosynthesis of Erythromycin and Rapamycin. Chemical Reviews. 97: 2611-2630. PMID 11851474 DOI: 10.1021/Cr9600316 |
0.467 |
|
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