☰

William P. Katt, Ph.D. - Publications

Affiliations: 
2009 Yale University, New Haven, CT 
Area:
chemical biology
Tree Info Similar researchers PubMed Report error

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Milano SK, Huang Q, Nguyen TT, Ramachandran S, Finke A, Kriksunov I, Schuller D, Szebenyi M, Arenholz E, McDermott LA, Sukumar N, Cerione RA, Katt WP. New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography. The Journal of Biological Chemistry. 101535. PMID 34954143 DOI: 10.1016/j.jbc.2021.101535  0.372
2020 Singleton DC, Dechaume AL, Murray PM, Katt WP, Baguley BC, Leung EY. Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer. Bmc Cancer. 20: 470. PMID 32450839 DOI: 10.1186/S12885-020-06885-3  0.334
2020 Katt WP. Patents targeting the Warburg effect for cancer therapy: an interview with William P Katt. Pharmaceutical Patent Analyst. PMID 32057283 DOI: 10.4155/Ppa-2020-0001  0.38
2019 Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA. Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Cell Reports. 29: 76-88.e7. PMID 31577957 DOI: 10.1016/J.Celrep.2019.08.076  0.312
2019 Katt WP, Lukey MJ, Cerione RA. Starving the Devourer: Cutting Cancer Off from Its Favorite Foods. Cell Chemical Biology. 26: 1197-1199. PMID 31539503 DOI: 10.1016/J.Chembiol.2019.09.005  0.329
2019 McDermott L, Koes D, Mohammed S, Iyer P, Boby M, Balasubramanian V, Geedy M, Katt W, Cerione R. GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency. Bioorganic & Medicinal Chemistry Letters. 126632. PMID 31474484 DOI: 10.1016/J.Bmcl.2019.126632  0.442
2019 Katt WP, Cerione RA. Inhibition of cancer metabolism: a patent landscape. Pharmaceutical Patent Analyst. PMID 31414969 DOI: 10.4155/Ppa-2019-0012  0.331
2018 Katt WP, Blobel NJ, Komarova S, Antonyak MA, Nakano I, Cerione RA. A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cells. Oncotarget. 9: 34379-34397. PMID 30344949 DOI: 10.18632/Oncotarget.26193  0.389
2018 Lukey MJ, Katt WP, Cerione RA. Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential. Cancer Cell. 33: 795-797. PMID 29763620 DOI: 10.1016/J.Ccell.2018.04.009  0.332
2018 Katt WP, Antonyak MA, Cerione RA. The diamond anniversary of tissue transglutaminase: a protein of many talents. Drug Discovery Today. PMID 29362136 DOI: 10.1016/J.Drudis.2018.01.037  0.368
2018 Huang Q, Stalnecker C, Zhang C, McDermott LA, Iyer P, O'Neill J, Reimer S, Cerione RA, Katt WP. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. The Journal of Biological Chemistry. PMID 29317493 DOI: 10.1074/Jbc.M117.810101  0.484
2018 Katt WP, Cerione RA. Abstract A156: Traditional chemotherapeutic agents as selective inhibitors of glutaminase isozymes Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A156  0.449
2017 Katt WP, Lukey MJ, Cerione RA. A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis. Future Medicinal Chemistry. PMID 28111979 DOI: 10.4155/Fmc-2016-0190  0.335
2016 Lukey MJ, Katt WP, Cerione RA. Targeting amino acid metabolism for cancer therapy. Drug Discovery Today. PMID 27988359 DOI: 10.1016/J.Drudis.2016.12.003  0.308
2016 Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S. Mechanistic Basis of Glutaminase Activation: A Key Enzyme that Promotes Glutamine Metabolism in Cancer Cells. The Journal of Biological Chemistry. PMID 27542409 DOI: 10.1074/Jbc.M116.720268  0.325
2016 McDermott LA, Iyer P, Vernetti L, Rimer S, Sun J, Boby M, Yang T, Fioravanti M, O'Neill J, Wang L, Drakes D, Katt W, Huang Q, Cerione R. Design and evaluation of novel glutaminase inhibitors. Bioorganic & Medicinal Chemistry. PMID 26988803 DOI: 10.1016/J.Bmc.2016.03.009  0.447
2015 Katt WP, Cerione RA. Less than the sum of its parts, a leinamycin precursor has superior properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 26106161 DOI: 10.1073/Pnas.1510122112  0.31
2014 Katt WP, Cerione RA. Glutaminase regulation in cancer cells: a druggable chain of events. Drug Discovery Today. 19: 450-7. PMID 24140288 DOI: 10.1016/J.Drudis.2013.10.008  0.325
2012 Katt WP, Ramachandran S, Erickson JW, Cerione RA. Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Molecular Cancer Therapeutics. 11: 1269-78. PMID 22496480 DOI: 10.1158/1535-7163.Mct-11-0942  0.412
2010 Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/Jm1001748  0.636
2010 Ross NT, Katt WP, Hamilton AD. Synthetic mimetics of protein secondary structure domains. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 368: 989-1008. PMID 20123744 DOI: 10.1098/Rsta.2009.0210  0.494
2009 Rodriguez JM, Ross NT, Katt WP, Dhar D, Lee GI, Hamilton AD. Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface. Chemmedchem. 4: 649-56. PMID 19330783 DOI: 10.1002/Cmdc.200800387  0.643
2009 Cummings CG, Ross NT, Katt WP, Hamilton AD. Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. Organic Letters. 11: 25-8. PMID 19035840 DOI: 10.1021/Ol8022962  0.688
2009 Siddiquee KAZ, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects (ACS Chemical Biology (2007) 2, (787-798)) Acs Chemical Biology. 4: 309. DOI: 10.1021/Cb9000684  0.533
2008 Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. Chembiochem : a European Journal of Chemical Biology. 9: 2800-3. PMID 19006150 DOI: 10.1002/Cbic.200800291  0.519
2008 Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/Jm800113P  0.719
2007 Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Schroeck C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. Acs Chemical Biology. 2: 787-98. PMID 18154266 DOI: 10.1021/Cb7001973  0.518
2007 Gunning PT, Katt WP, Glenn M, Siddiquee K, Siddique K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorganic & Medicinal Chemistry Letters. 17: 1875-8. PMID 17336521 DOI: 10.1016/J.Bmcl.2007.01.077  0.553
2007 Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Corrigendum to "Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains" [Bioorg. Med. Chem. Lett. 17 (2007) 1875-1878] (DOI:10.1016/j.bmcl.2007.01.077) Bioorganic and Medicinal Chemistry Letters. 17: 2949. DOI: 10.1016/J.Bmcl.2007.03.063  0.502
2003 Lavine BK, Davidson CE, Breneman C, Katt W, Sundling CM. Electronic van der Waals surface property descriptors and genetic algorithms for developing structure-activity correlations in olfactory databases. Journal of Chemical Information and Computer Sciences. 43: 1890-905. PMID 14632438 DOI: 10.1021/Ci030016J  0.301
Show low-probability matches.