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Thomas T. Joseph, M.D., Ph.D. - Publications

Affiliations: 
2003-2011 Biophysics, Structural Biology, and Biomathematics Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2003-2012 Medicine Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2012-2016 Anesthesiology, Perioperative and Pain medicine Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2016- Anesthesiology and Critical Care University of Pennsylvania Perelman School of Medicine 
Area:
Biophysics, Anesthesiology
Website:
https://www.med.upenn.edu/apps/faculty/index.php/g275/p8927371
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pitman C, Santiago-McRae E, Lohia R, Bassi K, Joseph TT, Hansen MEB, Brannigan G. The blobulator: a webtool for identification and visual exploration of hydrophobic modularity in protein sequences. Biorxiv : the Preprint Server For Biology. PMID 38293114 DOI: 10.1101/2024.01.15.575761  0.637
2024 Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology. PMID 38260485 DOI: 10.1101/2024.01.10.575040  0.707
2023 Becker-Baldus J, Yeliseev A, Joseph TT, Sigurdsson ST, Zoubak L, Hines K, Iyer MR, van den Berg A, Stepnowski S, Zmuda J, Gawrisch K, Glaubitz C. Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles. Acs Omega. 8: 32963-32976. PMID 37720784 DOI: 10.1021/acsomega.3c04681  0.34
2022 Petroff JT, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL. Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nature Communications. 13: 7017. PMID 36385237 DOI: 10.1038/s41467-022-34813-5  0.681
2021 Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G. Ketamine Metabolite (2,6)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. Acs Chemical Neuroscience. PMID 33905229 DOI: 10.1021/acschemneuro.0c00741  0.738
2021 Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K. Cholesterol as a modulator of cannabinoid receptor CB signaling. Scientific Reports. 11: 3706. PMID 33580091 DOI: 10.1038/s41598-021-83245-6  0.347
2020 Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM. Mechanistic insights into volatile anesthetic modulation of K2P channels. Elife. 9. PMID 33345771 DOI: 10.7554/eLife.59839  0.539
2020 Murlidaran S, Bu W, Eckenhoff RG, Brannigan GH, Joseph TT. Relative Affinities of General Anesthetics for Experimentally Identified Binding Sites in Ryanodine Receptors (RyR1) Biophysical Journal. 118: 115a. DOI: 10.1016/J.Bpj.2019.11.771  0.693
2019 McKinstry-Wu A, Woll KA, Joseph T, Bu W, White ER, Bhanu NV, Garcia BA, Brannigan G, Dailey WP, Eckenhoff RG. Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. Acs Chemical Neuroscience. PMID 31638765 DOI: 10.1021/Acschemneuro.9B00484  0.739
2018 Salari R, Joseph T, Lohia R, Hénin J, Brannigan G. A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation. PMID 30358394 DOI: 10.1021/Acs.Jctc.8B00447  0.668
2018 Riegelhaupt PM, Woll KA, Joseph TT, Vaidya KA, Nimigean CM, Eckenhoff RG. Identification of a Modulatory Site of Action for the Volatile Anesthetic Isoflurane in TREK1 Tandem Pore Potassium Channels Biophysical Journal. 114: 487a-488a. DOI: 10.1016/J.Bpj.2017.11.2675  0.536
2018 Joseph TT, Eckenhoff RG, Brannigan G. The pH Dependence of Ketamine Binding to G-Protein Coupled Receptors Biophysical Journal. 114: 226a. DOI: 10.1016/J.Bpj.2017.11.1260  0.742
2016 Joseph TT, Mincer JS. Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel. Plos One. 11: e0158795. PMID 27403526 DOI: 10.1371/Journal.Pone.0158795  0.509
2012 Joseph TT, Osman R. Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network. Plos Computational Biology. 8: e1002693. PMID 23028290 DOI: 10.1371/Journal.Pcbi.1002693  0.583
2012 Joseph TT, Osman R. Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins. 80: 1283-98. PMID 22275138 DOI: 10.1002/Prot.24025  0.573
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