Edward B. Lee, MD PhD - Publications

Affiliations: 
Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Website:
http://www.med.upenn.edu/cndr/AlphaStaffListing.shtml#L

191 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Shantaraman A, Dammer EB, Ugochukwu O, Duong DM, Yin L, Carter EK, Gearing M, Chen-Plotkin A, Lee EB, Trojanowski JQ, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Higginbotham L. Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 38328211 DOI: 10.1101/2024.01.23.576728  0.586
2024 Arezoumandan S, Cousins KAQ, Ohm DT, Lowe M, Chen M, Gee J, Phillips JS, McMillan CT, Luk KC, Deik A, Spindler MA, Tropea TF, Weintraub D, Wolk DA, Grossman M, ... ... Lee EB, et al. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of Clinical and Translational Neurology. PMID 38263854 DOI: 10.1002/acn3.51988  0.831
2024 Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, et al. Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid. Medrxiv : the Preprint Server For Health Sciences. PMID 38260316 DOI: 10.1101/2024.01.10.24301099  0.357
2023 Lyu X, Duong MT, Xie L, de Flores R, Richardson H, Hwang G, Wisse LEM, DiCalogero M, McMillan CT, Robinson JL, Xie SX, Lee EB, Irwin DJ, Dickerson BC, Davatzikos C, et al. Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38050662 DOI: 10.1002/alz.13559  0.661
2023 Phillips JS, Robinson JL, Cousins KAQ, Wolk DA, Lee EB, McMillan CT, Trojanowski JQ, Grossman M, Irwin DJ. Polypathologic associations with grey matter atrophy in neurodegenerative disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38050082 DOI: 10.1523/JNEUROSCI.0808-23.2023  0.604
2023 Ohm DT, Rhodes E, Bahena A, Capp N, Lowe M, Sabatini P, Trotman W, Olm CA, Phillips J, Prabhakaran K, Rascovsky K, Massimo L, McMillan C, Gee J, Tisdall MD, ... ... Lee EB, et al. Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient. Frontiers in Neurology. 14: 1245886. PMID 37900607 DOI: 10.3389/fneur.2023.1245886  0.76
2023 Stewart W, Buckland ME, Abdolmohammadi B, Affleck AJ, Alvarez VE, Gilchrist S, Huber BR, Lee EB, Lyall DM, Nowinski CJ, Russell ER, Stein TD, Suter CM, McKee AC. Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career. Acta Neuropathologica. PMID 37872234 DOI: 10.1007/s00401-023-02644-3  0.391
2023 Creekmore BC, Watanabe R, Lee EB. Neurodegenerative Disease Tauopathies. Annual Review of Pathology. PMID 37832941 DOI: 10.1146/annurev-pathmechdis-051222-120750  0.355
2023 Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, ... ... Lee EB, et al. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. Biorxiv : the Preprint Server For Biology. PMID 37808727 DOI: 10.1101/2023.09.29.560245  0.563
2023 Kang JH, Korecka M, Lee EB, Cousins KAQ, Tropea TF, Chen-Plotkin AA, Irwin DJ, Wolk D, Brylska M, Wan Y, Shaw LM. Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology. Clinical Chemistry. PMID 37725909 DOI: 10.1093/clinchem/hvad139  0.643
2023 Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathologica. PMID 37589745 DOI: 10.1007/s00401-023-02620-x  0.757
2023 Ash S, Nevler N, Irwin DJ, Shellikeri S, Rascovsky K, Shaw L, Lee EB, Trojanowski JQ, Grossman M. Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia. Journal of Alzheimer's Disease Reports. 7: 589-604. PMID 37313492 DOI: 10.3233/ADR-220089  0.374
2023 Quintin S, Lloyd GM, Paterno G, Xia Y, Sorrentino Z, Bell BM, Gorion KM, Lee EB, Prokop S, Giasson BI. Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114. The Journal of Biological Chemistry. 104912. PMID 37307916 DOI: 10.1016/j.jbc.2023.104912  0.744
2023 Chen M, Burke S, Olm CA, Irwin DJ, Massimo L, Lee EB, Trojanowski JQ, Gee JC, Grossman M. Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration. Brain Communications. 5: fcad147. PMID 37223129 DOI: 10.1093/braincomms/fcad147  0.557
2023 Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, ... ... Lee EB, et al. Creating the Pick's disease International Consortium: Association study of H2 haplotype with risk of Pick's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37163045 DOI: 10.1101/2023.04.17.23288471  0.737
2023 Young AL, Vogel JW, Robinson JL, McMillan CT, Ossenkoppele R, Wolk DA, Irwin DJ, Elman L, Grossman M, Lee VM, Lee EB, Hansson O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies. Brain : a Journal of Neurology. PMID 37150879 DOI: 10.1093/brain/awad145  0.578
2023 Cousins KAQ, Irwin DJ, Chen-Plotkin A, Shaw LM, Arezoumandan S, Lee EB, Wolk DA, Weintraub D, Spindler M, Deik A, Grossman M, Tropea TF. Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease. Annals of Clinical and Translational Neurology. PMID 37000892 DOI: 10.1002/acn3.51768  0.654
2023 Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Lee EB. Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance. Biorxiv : the Preprint Server For Biology. PMID 36993559 DOI: 10.1101/2023.03.15.532082  0.736
2023 Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ. Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathologica. PMID 36930297 DOI: 10.1007/s00401-023-02556-2  0.787
2023 Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, et al. Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. PMID 36917977 DOI: 10.1016/j.neuron.2023.02.019  0.541
2023 Tropea TF, Albuja I, Cousins KAQ, Irwin DJ, Lee EB, Chen-Plotkin AS. Concomitant Alzheimer's Disease Pathology in Parkinson's Disease Dementia. Annals of Neurology. PMID 36892304 DOI: 10.1002/ana.26635  0.629
2023 Robinson JL, Xie SX, Baer DR, Suh E, Van Deerlin VM, Loh NJ, Irwin D, McMillan CT, Wolk D, Chen-Plotkin A, Weintraub D, Schuck T, Lee VM, Trojanowski JQ, Lee EB. Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated. Brain : a Journal of Neurology. PMID 36864661 DOI: 10.1093/brain/awad059  0.775
2023 Kim BJ, Grossman M, Aleman TS, Song D, Cousins KAQ, McMillan CT, Saludades A, Yu Y, Lee EB, Wolk D, Van Deerlin VM, Shaw LM, Ying GS, Irwin DJ. Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease. Neurobiology of Aging. 125: 74-82. PMID 36857870 DOI: 10.1016/j.neurobiolaging.2023.01.015  0.339
2023 Lyu X, Duong MT, Xie L, de Flores R, Richardson H, Hwang G, Wisse LEM, DiCalogero M, McMillan CT, Robinson JL, Xie SX, Grossman M, Lee EB, Irwin DJ, Dickerson BC, et al. Tau-Neurodegeneration reveals vulnerability and resilience to comorbidities in Alzheimer's continuum. Medrxiv : the Preprint Server For Health Sciences. PMID 36824762 DOI: 10.1101/2023.02.12.23285594  0.632
2023 Young AL, Vogel JW, Robinson JL, McMillan CT, Ossenkoppele R, Wolk DA, Irwin DJ, Elman L, Grossman M, Lee VM, Lee EB, Hansson O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies. Medrxiv : the Preprint Server For Health Sciences. PMID 36778217 DOI: 10.1101/2023.01.31.23285242  0.573
2022 Robinson JL, Richardson H, Xie SX, Alfaro B, Loh N, Lee VM, Lee EB, Trojanowski JQ. Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment. Free Neuropathology. 3. PMID 37250748 DOI: 10.17879/freeneuropathology-2022-3792  0.672
2022 Tropea TF, Waligorska T, Xie SX, Nasrallah IM, Cousins KAQ, Trojanowski JQ, Grossman M, Irwin DJ, Weintraub D, Lee EB, Wolk DA, Chen-Plotkin AS, Shaw LM. Plasma phosphorylated tau181 predicts cognitive and functional decline. Annals of Clinical and Translational Neurology. PMID 36518085 DOI: 10.1002/acn3.51695  0.773
2022 Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, et al. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathologica. PMID 36512061 DOI: 10.1007/s00401-022-02524-2  0.492
2022 Olm CA, Burke SE, Peterson C, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M, Gee JC. Event-based modeling of T1-weighted MRI is related to pathology in frontotemporal lobar degeneration due to tau and TDP. Neuroimage. Clinical. 37: 103285. PMID 36508888 DOI: 10.1016/j.nicl.2022.103285  0.526
2022 Sadaghiani S, Trotman W, Lim SA, Chung E, Ittyerah R, Ravikumar S, Khandelwal P, Prabhakaran K, Lavery ML, Ohm DT, Gabrielyan M, Das SR, Schuck T, Capp N, Peterson CS, ... ... Lee EB, et al. Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36464907 DOI: 10.1002/alz.12884  0.787
2022 Uemura MT, Suh ER, Robinson JL, Brunden KR, Grossman M, Irwin DJ, Lee VM, Trojanowski JQ, Lee EB, Van Deerlin VM. Abundant co-pathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions, and ageing-related tau astrogliopathy in a family with a GBE1 mutation. Neuropathology and Applied Neurobiology. e12865. PMID 36456471 DOI: 10.1111/nan.12865  0.666
2022 Coughlin DG, Hiniker A, Peterson C, Kim Y, Arezoumandan S, Giannini L, Pizzo D, Weintraub D, Siderowf A, Litvan I, Rissman RA, Galasko D, Hansen L, Trojanowski JQ, Lee E, et al. Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. Journal of Neuropathology and Experimental Neurology. PMID 36269086 DOI: 10.1093/jnen/nlac094  0.565
2022 Cousins KAQ, Shaw LM, Chen-Plotkin A, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Grossman M, Irwin DJ. Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers. Jama Neurology. PMID 36215050 DOI: 10.1001/jamaneurol.2022.3265  0.624
2022 Kim B, Suh E, Nguyen AT, Prokop S, Mikytuck B, Olatunji OA, Robinson JL, Grossman M, Phillips JS, Irwin DJ, Mechanic-Hamilton D, Wolk DA, Trojanowski JQ, McMillan CT, Van Deerlin VM, ... Lee EB, et al. TREM2 risk variants are associated with atypical Alzheimer's disease. Acta Neuropathologica. PMID 36112222 DOI: 10.1007/s00401-022-02495-4  0.832
2022 Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathologica. PMID 36066634 DOI: 10.1007/s00401-022-02487-4  0.775
2022 Quilico Cousins KA, Arezoumandan S, Shellikeri S, Ohm D, Shaw LM, Grossman M, Wolk D, McMillan CT, Chen-Plotkin A, Lee E, Trojanowski JQ, Zetterberg H, Blennow K, Irwin DJ. CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology. Neurology. PMID 36041863 DOI: 10.1212/WNL.0000000000201202  0.829
2022 Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, ... ... Lee EB, et al. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35997131 DOI: 10.1002/mds.29164  0.526
2022 Shellikeri S, Cho S, Cousins KAQ, Liberman M, Howard E, Balganorth Y, Weintraub D, Spindler M, Deik A, Lee EB, Trojanowski JQ, Irwin D, Wolk D, Grossman M, Nevler N. Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias. Parkinsonism & Related Disorders. 102: 94-100. PMID 35985146 DOI: 10.1016/j.parkreldis.2022.07.023  0.581
2022 Diaz-Ortiz ME, Seo Y, Posavi M, Carceles Cordon M, Clark E, Jain N, Charan R, Gallagher MD, Unger TL, Amari N, Skrinak RT, Davila-Rivera R, Brody EM, Han N, Zack R, ... ... Lee EB, et al. GPNMB confers risk for Parkinson's disease through interaction with α-synuclein. Science (New York, N.Y.). 377: eabk0637. PMID 35981040 DOI: 10.1126/science.abk0637  0.544
2022 Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL, Yoshida M, Pereira FL, et al. Rainwater Charitable Foundation criteria for the neuropathologic diagnosis progressive supranuclear palsy. Acta Neuropathologica. PMID 35947184 DOI: 10.1007/s00401-022-02479-4  0.543
2022 Cousins KAQ, Shaw LM, Shellikeri S, Dratch L, Rosario L, Elman LB, Quinn C, Amado DA, Wolk DA, Tropea TF, Chen-Plotkin A, Irwin DJ, Grossman M, Lee EB, Trojanowski JQ, et al. Elevated plasma phosphorylated tau 181 in amyotrophic lateral sclerosis. Annals of Neurology. PMID 35877814 DOI: 10.1002/ana.26462  0.713
2022 Arezoumandan S, Xie SX, Cousins KAQ, Mechanic-Hamilton DJ, Peterson CS, Huang CY, Ohm DT, Ittyerah R, McMillan CT, Wolk DA, Yushkevich P, Trojanowski JQ, Lee EB, Grossman M, Phillips JS, et al. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta Neuropathologica. PMID 35871112 DOI: 10.1007/s00401-022-02472-x  0.819
2022 Walker IM, Cousins KA, Siderowf A, Duda JE, Morley JF, Dahodwala N, Tropea T, Vaishnavi S, Wolk DA, Chen-Plotkin AS, Shaw LM, Lee EB, Trojanowski JQ, Grossman M, Weintraub D, et al. Non-tremor motor dysfunction in Lewy body dementias is associated with AD biomarkers. Parkinsonism & Related Disorders. 100: 33-36. PMID 35700626 DOI: 10.1016/j.parkreldis.2022.05.022  0.722
2022 Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Lateralized and pathology in a case of Lewy body disease with corticobasal syndrome. Alzheimer's & Dementia (New York, N. Y.). 8: e12294. PMID 35592691 DOI: 10.1002/trc2.12294  0.603
2022 Ameen-Ali KE, Bretzin A, Lee EB, Folkerth R, Hazrati LN, Iacono D, Keene CD, Kofler J, Kovacs GG, Nolan A, Perl DP, Priemer DS, Smith DH, Wiebe DJ, Stewart W. Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change. Acta Neuropathologica Communications. 10: 50. PMID 35410438 DOI: 10.1186/s40478-022-01353-4  0.333
2022 Cervantes González A, Irwin DJ, Alcolea D, McMillan CT, Chen-Plotkin A, Wolk D, Sirisi S, Dols-Icardo O, Querol-Vilaseca M, Illán-Gala I, Santos-Santos MA, Fortea J, Lee EB, Trojanowski JQ, Grossman M, et al. Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration. Molecular Neurodegeneration. 17: 29. PMID 35395770 DOI: 10.1186/s13024-022-00534-y  0.672
2022 Burke SE, Phillips JS, Olm CA, Peterson CS, Cook PA, Gee JC, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M. Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology. Neurobiology of Aging. 113: 95-107. PMID 35325815 DOI: 10.1016/j.neurobiolaging.2022.02.007  0.529
2022 Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ. Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35318284 DOI: 10.1523/JNEUROSCI.2061-21.2022  0.786
2022 Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, ... ... Lee EB, et al. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nature Communications. 13: 1362. PMID 35292638 DOI: 10.1038/s41467-022-28896-3  0.71
2022 Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathologica Communications. 10: 33. PMID 35287730 DOI: 10.1186/s40478-022-01334-7  0.484
2022 Ohm DT, Cousins KAQ, Xie SX, Peterson C, McMillan CT, Massimo L, Raskovsky K, Wolk DA, Van Deerlin VM, Elman L, Spindler M, Deik A, Trojanowski JQ, Lee EB, Grossman M, et al. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta Neuropathologica. PMID 34997851 DOI: 10.1007/s00401-021-02402-3  0.789
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.744
2021 Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, et al. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. Neuroimage. Clinical. 33: 102913. PMID 34952351 DOI: 10.1016/j.nicl.2021.102913  0.799
2021 Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, ... ... Lee EB, et al. Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease. Acta Neuropathologica. PMID 34854996 DOI: 10.1007/s00401-021-02383-3  0.7
2021 Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M, Irwin DJ. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau. Acta Neuropathologica Communications. 9: 184. PMID 34794500 DOI: 10.1186/s40478-021-01290-8  0.495
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Lee EB, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.751
2021 Ravikumar S, Wisse LEM, Lim S, Ittyerah R, Xie L, Bedard ML, Das SR, Lee EB, Tisdall MD, Prabhakaran K, Lane J, Detre JA, Mizsei G, Trojanowski JQ, Robinson JL, et al. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta Neuropathologica Communications. 9: 173. PMID 34689831 DOI: 10.1186/s40478-021-01275-7  0.618
2021 Cousins KAQ, Bove J, Giannini LAA, Kinney NG, Balgenorth YR, Rascovsky K, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia. Alzheimer's & Dementia (New York, N. Y.). 7: e12188. PMID 34368417 DOI: 10.1002/trc2.12188  0.578
2021 Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, et al. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathologica Communications. 9: 134. PMID 34353357 DOI: 10.1186/s40478-021-01233-3  0.677
2021 Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, ... ... Lee EB, et al. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. The Journal of Cell Biology. 220. PMID 34347016 DOI: 10.1083/jcb.201910213  0.682
2021 Yushkevich PA, López MM, Martin MMIO, Ittyerah R, Lim S, Ravikumar S, Bedard ML, Pickup S, Liu W, Wang J, Hung LY, Lasserve J, Vergnet N, Xie L, Dong M, ... ... Lee EB, et al. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe. Brain : a Journal of Neurology. PMID 34259858 DOI: 10.1093/brain/awab262  0.8
2021 Mao F, Robinson JL, Unger T, Posavi M, Amado DA, Elman L, Grossman M, Wolk DA, Lee EB, Van Deerlin VM, Porta S, Lee VMY, Trojanowski JQ, Chen-Plotkin AS. TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy. Acta Neuropathologica. PMID 34152475 DOI: 10.1007/s00401-021-02330-2  0.687
2021 Lin YC, Kumar MS, Ramesh N, Anderson EN, Nguyen AT, Kim B, Cheung S, McDonough JA, Skarnes WC, Lopez-Gonzalez R, Landers JE, Fawzi NL, Mackenzie IRA, Lee EB, Nickerson JA, et al. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature Neuroscience. PMID 34059832 DOI: 10.1038/s41593-021-00859-9  0.691
2021 Porta S, Xu Y, Lehr T, Zhang B, Meymand E, Olufemi M, Stieber A, Lee EB, Trojanowski JQ, Lee VM. Distinct Brain-derived TDP-43 Strains from FTLD-TDP Subtypes Induce Diverse Morphological TDP-43 Aggregates and Spreading Patterns in vitro and in vivo. Neuropathology and Applied Neurobiology. PMID 33971027 DOI: 10.1111/nan.12732  0.646
2021 Kim B, Mikytuck B, Suh E, Gibbons GS, Van Deerlin VM, Vaishnavi SN, Spindler MA, Massimo L, Grossman M, Trojanowski JQ, Irwin DJ, Lee EB. Tau immunotherapy is associated with glial responses in FTLD-tau. Acta Neuropathologica. PMID 33950293 DOI: 10.1007/s00401-021-02318-y  0.575
2021 Zhang JV, Irwin DJ, Blennow K, Zetterberg H, Lee EB, Shaw LM, Rascovsky K, Massimo L, McMillan CT, Chen-Plotkin A, Elman L, Lee VM, McCluskey L, Toledo JB, Weintraub D, et al. Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration. Neurology. Clinical Practice. 11: 105-116. PMID 33842063 DOI: 10.1212/CPJ.0000000000000959  0.745
2021 Soares AC, Ferreira A, Mariën J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynck L. PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. The Journal of Biological Chemistry. 100636. PMID 33831417 DOI: 10.1016/j.jbc.2021.100636  0.585
2021 Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, ... ... Lee EB, et al. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathologica Communications. 9: 32. PMID 33648593 DOI: 10.1186/s40478-021-01122-9  0.451
2021 Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ. Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology. Acta Neuropathologica Communications. 9: 30. PMID 33622418 DOI: 10.1186/s40478-021-01129-2  0.813
2021 Nasrallah MP, Mourelatos Z, Lee EB. Neuropathology associated with SARS-CoV-2 infection. Lancet (London, England). 397: 277. PMID 33485446 DOI: 10.1016/S0140-6736(21)00096-9  0.597
2021 Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, et al. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta Neuropathologica. PMID 33399945 DOI: 10.1007/s00401-020-02255-2  0.578
2020 Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, Loh N, Porras-Paniagua M, Nirschl JJ, Wolk D, Lee VM, Lee EB, Trojanowski JQ. The development and convergence of co-pathologies in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33449993 DOI: 10.1093/brain/awaa438  0.709
2020 Arena JD, Johnson VE, Lee EB, Gibbons GS, Smith DH, Trojanowski JQ, Stewart W. Astroglial tau pathology alone preferentially concentrates at sulcal depths in chronic traumatic encephalopathy neuropathologic change. Brain Communications. 2: fcaa210. PMID 33426528 DOI: 10.1093/braincomms/fcaa210  0.533
2020 Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, ... ... Lee EB, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 33367843 DOI: 10.1093/jnen/nlaa153  0.72
2020 Placek K, Benatar M, Wuu J, Rampersaud E, Hennessy L, Van Deerlin VM, Grossman M, Irwin DJ, Elman L, McCluskey L, Quinn C, Granit V, Statland JM, Burns TM, Ravits J, ... ... Lee EB, et al. Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis. Embo Molecular Medicine. e12595. PMID 33270986 DOI: 10.15252/emmm.202012595  0.467
2020 Cousins KAQ, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, Zetterberg H, Blennow K, Burke SE, Kinney NG, Gibbons GS, McMillan CT, Trojanowski JQ, Grossman M. ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33226735 DOI: 10.1002/alz.12233  0.568
2020 Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, et al. Tau pathology associates with in vivo cortical thinning in Lewy body disorders. Annals of Clinical and Translational Neurology. PMID 33108692 DOI: 10.1002/acn3.51183  0.712
2020 Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, ... ... Lee EB, et al. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.). PMID 33004675 DOI: 10.1126/science.aay8826  0.824
2020 Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, et al. Multimodal in vivo and postmortem assessments of tau in Lewy body disorders. Neurobiology of Aging. 96: 137-147. PMID 33002767 DOI: 10.1016/J.Neurobiolaging.2020.08.003  0.75
2020 Coughlin DG, Ittyerah R, Peterson C, Phillips JS, Miller S, Rascovsky K, Weintraub DA, Siderowf AD, Duda JE, Hurtig HI, Wolk DA, McMillan C, Yushkevich PA, Grossman M, Lee EB, et al. Hippocampal Subfield Pathologic Burden in Lewy Body Diseases versus Alzheimer's Disease. Neuropathology and Applied Neurobiology. PMID 32892355 DOI: 10.1111/Nan.12659  0.65
2020 Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathologica. PMID 32840654 DOI: 10.1007/S00401-020-02200-3  0.765
2020 Robinson JL, Porta S, Garrett FG, Zhang P, Xie SX, Suh E, Van Deerlin VM, Abner EL, Jicha GA, Barber JM, Lee VM, Lee EB, Trojanowski JQ, Nelson PT. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration. Brain : a Journal of Neurology. PMID 32830216 DOI: 10.1093/Brain/Awaa219  0.747
2020 Ohm DT, Peterson C, Lobrovich R, Cousins KAQ, Gibbons GS, McMillan CT, Wolk DA, Van Deerlin V, Elman L, Spindler M, Deik A, Siderowf A, Trojanowski JQ, Lee EB, Grossman M, et al. Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum. Acta Neuropathologica. PMID 32804255 DOI: 10.1007/S00401-020-02210-1  0.83
2020 Katsumata Y, Abner EL, Karanth S, Teylan MA, Mock CN, Cykowski MD, Lee EB, Boehme KL, Mukherjee S, Kauwe JSK, Kryscio RJ, Schmitt FA, Fardo DW, Nelson PT. Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy. Acta Neuropathologica. PMID 32797255 DOI: 10.1007/S00401-020-02211-0  0.548
2020 Dai DL, Tropea TF, Robinson JL, Suh E, Hurtig H, Weintraub D, Van Deerlin V, Lee EB, Trojanowski JQ, Chen-Plotkin AS. ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies. Acta Neuropathologica. PMID 32749525 DOI: 10.1007/S00401-020-02199-7  0.74
2020 Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS. Defining and predicting transdiagnostic categories of neurodegenerative disease. Nature Biomedical Engineering. PMID 32747831 DOI: 10.1038/S41551-020-0593-Y  0.706
2020 Cousins KAQ, Irwin DJ, Wolk DA, Lee EB, Shaw LMJ, Trojanowski JQ, Da Re F, Gibbons GS, Grossman M, Phillips JS. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a Journal of Neurology. PMID 32666090 DOI: 10.1093/Brain/Awaa165  0.652
2020 Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a Journal of Neurology. PMID 32390044 DOI: 10.1093/Brain/Awaa071  0.747
2020 Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, et al. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathologica. PMID 32383020 DOI: 10.1007/S00401-020-02158-2  0.732
2020 de Flores R, Wisse LEM, Das SR, Xie L, McMillan CT, Trojanowski JQ, Robinson JL, Grossman M, Lee E, Irwin DJ, Yushkevich PA, Wolk DA. Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32323446 DOI: 10.1002/Alz.12079  0.627
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/S41591-020-0815-6  0.608
2019 Robinson JL, Yan N, Caswell C, Xie SX, Suh E, Van Deerlin VM, Gibbons G, Irwin DJ, Grossman M, Lee EB, Lee VM, Miller B, Trojanowski JQ. Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD. Journal of Neuropathology and Experimental Neurology. PMID 31999351 DOI: 10.1093/Jnen/Nlz141  0.751
2019 Spotorno N, Hall S, Irwin DJ, Rumetshofer T, Acosta-Cabronero J, Deik AF, Spindler MA, Lee EB, Trojanowski JQ, van Westen D, Nilsson M, Grossman M, Nestor PJ, McMillan CT, Hansson O. Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies. Radiology. 190406. PMID 31617796 DOI: 10.1148/Radiol.2019190406  0.499
2019 Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM. Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology. PMID 31537715 DOI: 10.1212/Wnl.0000000000008387  0.627
2019 Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ. Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration. Frontiers in Neuroscience. 13: 682. PMID 31333403 DOI: 10.3389/Fnins.2019.00682  0.535
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, ... ... Lee EB, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/S00401-019-02045-5  0.721
2019 Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W. Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta Neuropathologica. PMID 31152201 DOI: 10.1007/S00401-019-02030-Y  0.621
2019 Phillips JS, Da Re F, Irwin DJ, McMillan CT, Vaishnavi SN, Xie SX, Lee EB, Cook PA, Gee JC, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer's disease. Brain : a Journal of Neurology. 142: 1701-1722. PMID 31135048 DOI: 10.1093/Brain/Awz091  0.616
2019 Viaene AN, Lee EB, Rosenbaum JN, Nasrallah IM, Nasrallah MP. Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas. Acta Neuropathologica Communications. 7: 69. PMID 31046843 DOI: 10.1186/S40478-019-0722-6  0.579
2019 Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. Cell Reports. 27: 1409-1421.e6. PMID 31042469 DOI: 10.1016/J.Celrep.2019.04.003  0.321
2019 Giannini LA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia. Annals of Neurology. PMID 30851133 DOI: 10.1002/Ana.25465  0.617
2019 Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, ... ... Lee EB, et al. Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology. 18: 231-233. PMID 30784550 DOI: 10.1016/S1474-4422(19)30020-1  0.449
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Lee EB, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9  0.522
2019 Darwich NF, Phan JM, Suh ER, Toro C, Grossman M, Irwin D, McMillan CT, Aguirre GK, Van Deerlin VM, Lee EB. A HYPOMORPH MUTATION OF THE TAU DISAGGREGASE VCP IS ASSOCIATED WITH VACUOLAR TAUOPATHY Alzheimer's & Dementia. 15: P1603. DOI: 10.1016/J.Jalz.2019.09.071  0.336
2018 Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, ... Lee EB, et al. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of Neurology. PMID 30549331 DOI: 10.1002/Ana.25392  0.746
2018 Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 73: 190-199. PMID 30368160 DOI: 10.1016/J.Neurobiolaging.2018.09.031  0.54
2018 Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nature Communications. 9: 4220. PMID 30310141 DOI: 10.1038/S41467-018-06548-9  0.702
2018 Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A. Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30297518 DOI: 10.1136/Jnnp-2018-318993  0.559
2018 Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 30203094 DOI: 10.1093/Jnen/Nly080  0.695
2018 McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA. Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of Clinical and Translational Neurology. 5: 927-934. PMID 30128317 DOI: 10.1002/Acn3.581  0.617
2018 Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathologica Communications. 6: 50. PMID 29891013 DOI: 10.1186/S40478-018-0552-Y  0.722
2018 Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a Journal of Neurology. PMID 29878075 DOI: 10.1093/Brain/Awy146  0.803
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Lee EB, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.543
2018 Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29604263 DOI: 10.1016/J.Jalz.2018.02.015  0.738
2018 Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. Jama Neurology. PMID 29554190 DOI: 10.1001/Jamaneurol.2018.0118  0.627
2018 Lee EB. Integrated neurodegenerative disease autopsy diagnosis. Acta Neuropathologica. PMID 29502201 DOI: 10.1007/S00401-018-1827-X  0.349
2018 Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, et al. CSF tau and amyloid-beta predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. PMID 29467305 DOI: 10.1212/Wnl.0000000000005166  0.698
2018 Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, et al. Author response: Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism Elife. DOI: 10.7554/Elife.37754.025  0.322
2017 Wang L, Hubbard RA, Walker RL, Lee EB, Larson EB, Crane PK. Assessing robustness of hazard ratio estimates to outcome misclassification in longitudinal panel studies with application to Alzheimer's disease. Plos One. 12: e0190107. PMID 29272296 DOI: 10.1371/Journal.Pone.0190107  0.376
2017 Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29228211 DOI: 10.1093/Brain/Awx319  0.598
2017 Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63: 75-87. PMID 29223682 DOI: 10.1016/J.Neurobiolaging.2017.11.008  0.605
2017 Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 68. PMID 28877758 DOI: 10.1186/S40478-017-0471-3  0.691
2017 Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of Neurology. PMID 28719018 DOI: 10.1002/Ana.24996  0.624
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/J.Neuron.2017.05.037  0.735
2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology. PMID 28591867 DOI: 10.1093/Jnen/Nlx041  0.638
2017 Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. Neurology. PMID 28515265 DOI: 10.1212/Wnl.0000000000004034  0.633
2017 Liu EY, Cali CP, Lee EB. RNA metabolism in neurodegenerative disease. Disease Models & Mechanisms. 10: 509-518. PMID 28468937 DOI: 10.1242/Dmm.028613  0.317
2017 Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, et al. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 28340083 DOI: 10.1093/Jnen/Nlx007  0.739
2017 Jefferson-George KS, Wolk DA, Lee EB, McMillan CT. Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28322204 DOI: 10.1016/J.Jalz.2017.01.028  0.398
2017 Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica. PMID 28130640 DOI: 10.1007/S00401-017-1679-9  0.724
2017 Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology. 16: 55-65. PMID 27979356 DOI: 10.1016/S1474-4422(16)30291-5  0.637
2017 Da Re F, Phillips JS, Dratch L, Ferrarese C, Irwin DJ, McMillan CT, Lee E, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. [P4-238]: AMNESTIC AND NON-AMNESTIC PHENOTYPES OF ALZHEIMER'S DISEASE: AN MRI-BASED PHASING ANALYSIS Alzheimer's & Dementia. 13: P1365-P1366. DOI: 10.1016/J.Jalz.2017.06.2106  0.57
2016 Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M. Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders. Frontiers in Human Neuroscience. 10: 693. PMID 28123364 DOI: 10.3389/Fnhum.2016.00693  0.583
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/Bpa.12482  0.731
2016 McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathologica. PMID 27815633 DOI: 10.1007/S00401-016-1640-3  0.713
2016 Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, et al. Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and Applied Neurobiology. PMID 27716988 DOI: 10.1111/Nan.12362  0.53
2016 Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology. PMID 27683847 DOI: 10.1212/WNL.0000000000003250  0.643
2016 McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M. Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome. Neurology. PMID 27543644 DOI: 10.1212/Wnl.0000000000003119  0.542
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/S00401-015-1526-9  0.785
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Lee EB, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.751
2015 O'Rourke JG, Bogdanik L, Muhammad AK, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, ... ... Lee EB, et al. C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD. Neuron. 88: 892-901. PMID 26637796 DOI: 10.1016/J.Neuron.2015.10.027  0.337
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/Ana.24559  0.691
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.695
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/Journal.Pone.0141836  0.657
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/J.Jalz.2015.07.492  0.686
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/S40478-015-0219-X  0.679
2015 Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica. PMID 26022924 DOI: 10.1007/S00401-015-1445-9  0.554
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/S00401-015-1428-X  0.68
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/S00401-014-1380-1  0.728
2015 Russ J, Liu EY, Wu K, Neal D, Suh E, Irwin DJ, McMillan CT, Harms MB, Cairns NJ, Wood EM, Xie SX, Elman L, McCluskey L, Grossman M, Van Deerlin VM, ... Lee EB, et al. Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta Neuropathologica. 129: 39-52. PMID 25388784 DOI: 10.1007/S00401-014-1365-0  0.359
2014 McGurk L, Lee VM, Trojanowksi JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73: 837-45. PMID 25111021 DOI: 10.1097/Nen.0000000000000102  0.58
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/S00401-014-1328-5  0.741
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/Brain/Awu190  0.701
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/S00401-014-1308-9  0.732
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/S00401-014-1299-6  0.685
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/S00401-013-1238-Y  0.666
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/J.Jalz.2013.06.003  0.762
2013 Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie SX, Van Deerlin VM, Grossman M. Development and validation of pedigree classification criteria for frontotemporal lobar degeneration. Jama Neurology. 70: 1411-7. PMID 24081456 DOI: 10.1001/Jamaneurol.2013.3956  0.585
2013 Lee EB, Russ J, Jung H, Elman LB, Chahine LM, Kremens D, Miller BL, Branch Coslett H, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1: 1-11. PMID 24027631 DOI: 10.1186/2051-5960-1-9  0.618
2013 Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of Comparative Neurology. 521: 4339-55. PMID 23881776 DOI: 10.1002/Cne.23430  0.722
2013 Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of Neurology. 74: 20-38. PMID 23686809 DOI: 10.1002/Ana.23937  0.65
2013 Toledo J, Arnold S, Brettschneider J, Lee E, Irwin D, Xie S, Grossman M, Monsell S, Kukull W, Trojanowski J. O2-10-02: Importance of coincident neurodegenerative diseases Alzheimer's & Dementia. 9: P334-P334. DOI: 10.1016/J.Jalz.2013.04.190  0.511
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM, Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology. 135: 3749-56. PMID 23204143 DOI: 10.1093/Brain/Aws271  0.747
2012 Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids and Barriers of the Cns. 9: 7. PMID 22444461 DOI: 10.1186/2045-8118-9-7  0.597
2012 Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 123: 825-39. PMID 22426854 DOI: 10.1007/S00401-012-0970-Z  0.706
2012 Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews. Neuroscience. 13: 38-50. PMID 22127299 DOI: 10.1038/Nrn3121  0.674
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin VM, Virginia ML, Trojanowski JQ, Arnold SE. S5-02-04: Relationships of cerebrovascular atherosclerosis with amyloid, tau, α-synuclein and TDP-43 pathologies in neurodegenerative disease dementias Alzheimer's & Dementia. 8: P725-P725. DOI: 10.1016/J.Jalz.2012.05.1951  0.637
2011 Lee EB. Obesity, leptin, and Alzheimer's disease. Annals of the New York Academy of Sciences. 1243: 15-29. PMID 22211890 DOI: 10.1111/J.1749-6632.2011.06274.X  0.358
2011 Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87. PMID 21734300 DOI: 10.1523/Jneurosci.0618-11.2011  0.792
2011 Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7691-9. PMID 21613482 DOI: 10.1523/Jneurosci.6637-10.2011  0.711
2011 Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of Clinical Investigation. 121: 726-38. PMID 21206091 DOI: 10.1172/Jci44867  0.789
2010 Hamilton R, Patel S, Lee EB, Jackson EM, Lopinto J, Arnold SE, Clark CM, Basil A, Shaw LM, Xie SX, Grady MS, Trojanowski JQ. Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of Neurology. 68: 535-40. PMID 20687117 DOI: 10.1002/Ana.22015  0.607
2010 Prasad S, Lee EB, Woo JH, Alavi A, Galetta SL. Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. 30: 260-2. PMID 20581692 DOI: 10.1097/Wno.0B013E3181E2Aef7  0.33
2010 Arnold SE, Lee EB, Moberg PJ, Stutzbach L, Kazi H, Han LY, Lee VM, Trojanowski JQ. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of Neurology. 67: 462-9. PMID 20437581 DOI: 10.1002/Ana.21910  0.741
2009 Turkeltaub PE, Guzman MA, Lee EB, Galetta SL. Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome. Neurology. 73: 2037-9. PMID 19996079 DOI: 10.1212/Wnl.0B013E3181C55Ee7  0.521
2009 Lee EB, Tihan T, Scheithauer BW, Zhang PJ, Gonatas NK. Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? Journal of Neuropathology and Experimental Neurology. 68: 482-8. PMID 19525896 DOI: 10.1097/Nen.0B013E3181A13Fca  0.629
2009 Ko MW, Turkeltaub PE, Lee EB, Gonatas NK, Volpe NJ, Moster ML, Galetta SL. Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis. Journal of the Neurological Sciences. 278: 127-31. PMID 19135216 DOI: 10.1016/J.Jns.2008.11.026  0.644
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/S00401-008-0477-9  0.809
2008 Lee EB, Lee VM, Trojanowski JQ, Neumann M. TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta Neuropathologica. 115: 305-11. PMID 18087705 DOI: 10.1007/S00401-007-0331-5  0.711
2007 Prasad S, Ko MW, Lee EB, Gonatas NK, Stern MB, Galetta S. Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease. Journal of the Neurological Sciences. 253: 69-72. PMID 17234215 DOI: 10.1016/J.Jns.2006.11.010  0.672
2006 Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of Biological Chemistry. 281: 4292-9. PMID 16361260 DOI: 10.1074/Jbc.M511018200  0.692
2005 Lee EB, Leng LZ, Lee VM, Trojanowski JQ. Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. Febs Letters. 579: 2564-8. PMID 15862291 DOI: 10.1016/J.Febslet.2005.03.070  0.688
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005  0.584
2005 Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of Cell Biology. 168: 291-302. PMID 15642747 DOI: 10.1083/Jcb.200407070  0.744
2005 Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. 102: 227-31. PMID 15615853 DOI: 10.1073/Pnas.0406361102  0.67
2004 Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Praticò D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American Journal of Pathology. 165: 2197-206. PMID 15579461 DOI: 10.1016/S0002-9440(10)63269-5  0.791
2004 Yang H, Yao Y, Uryu K, Lee EB, Zhao L, Funk C, Trojanowski JQ, Lee VM, Pratico D. P2-112 Selective suppression of NF-κB by indomethacin modulates Aβlevels and deposition but not metabolism in a model of Alzheimer disease Neurobiology of Aging. 25: S256. DOI: 10.1016/S0197-4580(04)80859-5  0.678
2003 Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of Neuropathology and Experimental Neurology. 62: 368-80. PMID 12722829 DOI: 10.1093/Jnen/62.4.368  0.653
2003 Lee EB, Skovronsky DM, Abtahian F, Doms RW, Lee VM. Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of Biological Chemistry. 278: 4458-66. PMID 12480937 DOI: 10.1074/Jbc.M210105200  0.802
2001 Raben N, Danon M, Lu N, Lee E, Shliselfeld L, Skurat AV, Roach PJ, Lawrence JC, Musumeci O, Shanske S, DiMauro S, Plotz P. Surprises of genetic engineering: a possible model of polyglucosan body disease. Neurology. 56: 1739-45. PMID 11425943 DOI: 10.1212/Wnl.56.12.1739  0.34
1998 Lindstrom J, Peng X, Kuryatov A, Lee E, Anand R, Gerzanich V, Wang F, Wells G, Nelson M. Molecular and antigenic structure of nicotinic acetylcholine receptors Annals of the New York Academy of Sciences. 841: 71-86. PMID 9668222 DOI: 10.1111/J.1749-6632.1998.Tb10910.X  0.582
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