Kenneth Y. Kwan, Ph.D.
Affiliations: | Neuroscience | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
Cortical development, neural circuit assembly, neurodevelopmental disordersWebsite:
http://www.kwanlab.orgGoogle:
"Kenneth Y. Kwan"Bio:
Evolution of the cerebral cortex is thought to underlie our species’ most remarkable cognitive, perceptive, and motor capabilities, the execution of which depends on the precise establishment of connectivity during development. Miswiring of cortical circuitry can lead to disorders, including autism and schizophrenia, that affect the most distinctly human cognitive functions.
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Cross-listing: Neurotree
Parents
Sign in to add mentor| Nenad Sestan | grad student | 2003-2008 | Yale (Neurotree) | |
| (SOX5 regulates migration, postmigratory differentiation, and axonal projections of subplate and deep-layer neocortical neurons.) | ||||
| Nenad Sestan | post-doc | 2008-2013 | Yale School of Medicine (Neurotree) | |
Children
Sign in to add trainee| Steven Colvin | research assistant | 2013-2015 | University of Michigan |
| Ikenna P Njoku | grad student | 2022- | University of Michigan (Neurotree) |
| Karina Hernandez Quijada | grad student | 2023- | University of Michigan (Neurotree) |
| Jason Keil | grad student | 2014-2019 | (Neurotree) |
| Owen H. Funk | grad student | 2014-2021 | University of Michigan (Neurotree) |
| Daniel Doyle | grad student | 2016-2023 | University of Michigan (Neurotree) |
| Lei Shi | post-doc | 2015-2019 | University of Michigan (Neurotree) |
BETA: Related publications
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Publications
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| Molnár Z, Kwan KY. (2024) Development and Evolution of Thalamocortical Connectivity. Cold Spring Harbor Perspectives in Biology. 16 |
| Njoku IP, Kwan KY. (2023) Distinct microtubule networks mediate neuronal migration and polarization. Neuron. 111: 1168-1170 |
| Funk OH, Qalieh Y, Doyle DZ, et al. (2022) Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116956119 |
| Bae T, Fasching L, Wang Y, et al. (2022) Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science (New York, N.Y.). 377: 511-517 |
| Doyle DZ, Kwan KY. (2022) Neurogenic-angiogenic synchrony via lactate. Nature Neuroscience. 25: 839-840 |
| Yang T, Veling MW, Zhao XF, et al. (2022) Migrating pyramidal neurons require DSCAM to bypass the border of the developing cortical plate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Doyle DZ, Lam MM, Qalieh A, et al. (2021) Chromatin remodeler regulates subplate neuron identity and wiring of cortical connectivity. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Keil JM, Doyle DZ, Qalieh A, et al. (2020) Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications. 11: 3839 |
| Bott CJ, McMahon LP, Keil JM, et al. (2020) Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Shi L, Qalieh A, Lam MM, et al. (2019) Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications. 10: 2588 |