George L. Kenyon

Affiliations: 
1998-2010 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmaceutical Chemistry
Website:
http://faculty-history.dc.umich.edu/faculty/george-l-kenyon
Google:
"George Kenyon"
Bio:

http://chemistry.library.nd.edu/resources/genealogy/chemistry/documents/KenyonGL.pdf

Cross-listing: Chemistry Tree

Parents

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Frank H. Westheimer grad student 1965 Harvard (Chemistry Tree)
 (Studies on the mechanism of the alkaline decomposition of beta-haloalkylphosphonic acids)

Children

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JoAnne Stubbe grad student 1971 UC Berkeley (Chemistry Tree)
Michael A. Marletta grad student 1978 UCSF
Patricia C. Babbitt grad student 1988 UCSF (Chemistry Tree)
Simon H. Friedman grad student 1989-1996 UCSF (Chemistry Tree)
Sean M. Kerwin post-doc 1989-1991 UCSF (Chemistry Tree)
Jawad Alzeer post-doc 1998-2000 Michigan - Ann Arbor (Chemistry Tree)
Michael J. McLeish research scientist 1996-1997 UCSF (Chemistry Tree)
BETA: Related publications

Publications

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Brandt GS, Kneen MM, Chakraborty S, et al. (2009) Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. Biochemistry. 48: 3247-57
Chakraborty S, Nemeria NS, Balakrishnan A, et al. (2009) Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry. 48: 981-94
Wang PF, Yep A, Kenyon GL, et al. (2009) Using directed evolution to probe the substrate specificity of mandelamide hydrolase. Protein Engineering, Design & Selection : Peds. 22: 103-10
Brandt GS, Nemeria N, Chakraborty S, et al. (2008) Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. Biochemistry. 47: 7734-43
Yeung CK, Yep A, Kenyon GL, et al. (2008) Physical, kinetic and spectrophotometric studies of a NAD(P)-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633. Biochimica Et Biophysica Acta. 1784: 1248-55
Yep A, Kenyon GL, McLeish MJ. (2008) Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism. Proceedings of the National Academy of Sciences of the United States of America. 105: 5733-8
Chakraborty S, Nemeria N, Yep A, et al. (2008) Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects. Biochemistry. 47: 3800-9
Nemeria N, Korotchkina L, McLeish MJ, et al. (2007) Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states. Biochemistry. 46: 10739-44
Bera AK, Polovnikova LS, Roestamadji J, et al. (2007) Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme. Journal of the American Chemical Society. 129: 4120-1
Yep A, Kenyon GL, McLeish MJ. (2006) Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase. Bioorganic Chemistry. 34: 325-36
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