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Ladislau C. Kovari - Publications

Affiliations: 
Biochemistry and Molecular Biology Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Medical Biophysics, Pharmacy
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Muzzarelli KM, Brunzelle J, Kovari I, Yang Z, Kovari L. Structure‐Based Design and Evaluation of Peptidomimetic Inhibitors Against the Human Norovirus Protease The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09621  0.309
2020 Zhang Y, Martin K, Spellmon N, Perry E, Cao T, Muzzarelli K, Smith S, Brunzelle J, Kovari L, Jin J, Stemmler T, Li C, Yang Z. Crystal Structure of SMYD2 Reveals Simultaneous Binding of PARP1 Peptides to the Active Site and an Unexpected Secondary Binding Site The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09331  0.332
2019 Takamatsu Y, Aoki M, Bulut H, Das D, Amano M, Sheri VR, Kovari LC, Hayashi H, Delino NS, Ghosh AK, Mitsuya H. Novel protease inhibitors containing -5-modified -THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance. Antimicrobial Agents and Chemotherapy. PMID 31085520 DOI: 10.1128/Aac.00372-19  0.711
2019 Muzzarelli KM, Kuiper BD, Spellmon N, Brunzelle JS, Hackett J, Amblard F, Zhou S, Liu P, Kovari IA, Yang Z, Schinazi RF, Kovari LC. Structural and antiviral studies of the human norovirus GII.4 protease. Biochemistry. PMID 30605321 DOI: 10.1021/Acs.Biochem.8B01063  0.401
2018 Amblard F, Zhou S, Liu P, Yoon J, Cox B, Muzzarelli K, Kuiper BD, Kovari LC, Schinazi RF. Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29779977 DOI: 10.1016/J.Bmcl.2018.05.012  0.317
2018 Kuiper BD, Keusch BJ, Holcomb J, Muzzarelli KM, Amblard F, Liu P, Zhou S, Kovari IA, Yang Z, Schinazi RF, Kovari LC. Expression, purification, and characterization of a GII.4 norovirus protease. Infectious Disorders Drug Targets. PMID 29779487 DOI: 10.2174/1871526518666180521091158  0.334
2017 Kuiper BD, Slater K, Spellmon N, Holcomb J, Medapureddy P, Muzzarelli KM, Yang Z, Ovadia R, Amblard F, Kovari IA, Schinazi RF, Kovari LC. Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease. Biochemical and Biophysical Research Communications. PMID 28342876 DOI: 10.1016/J.Bbrc.2017.03.108  0.358
2015 Kuiper BD, Keusch BJ, Dewdney TG, Chordia P, Ross K, Brunzelle JS, Kovari IA, MacArthur R, Salimnia H, Kovari LC. The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops. Biochemistry and Biophysics Reports. 2: 160-165. PMID 29124158 DOI: 10.1016/J.Bbrep.2015.06.003  0.878
2015 Kuiper BD, Keusch BJ, Dewdney TG, Chordia P, Ross K, Brunzelle JS, Kovari IA, MacArthur R, Salimnia H, Kovari LC. The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops Biochemistry and Biophysics Reports. 2: 160-165. DOI: 10.1016/j.bbrep.2015.06.003  0.864
2014 Chordia P, Dewdney TG, Keusch B, Kuiper BD, Ross K, Kovari IA, MacArthur R, Salimnia H, Kovari LC. The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics. Discoveries (Craiova, Romania). 2: e27. PMID 32309558 DOI: 10.15190/d.2014.19  0.866
2014 Yedidi RS, Proteasa G, Martin PD, Liu Z, Vickrey JF, Kovari IA, Kovari LC. A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF. Journal of Molecular Graphics & Modelling. 53: 105-11. PMID 25108107 DOI: 10.1016/J.Jmgm.2014.06.010  0.854
2014 Yedidi RS, Liu Z, Kovari IA, Woster PM, Kovari LC. P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease Journal of Molecular Graphics and Modelling. 47: 18-24. PMID 24291501 DOI: 10.1016/J.Jmgm.2013.10.010  0.844
2013 Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease Bioorganic and Medicinal Chemistry. 21: 7430-7434. PMID 24128815 DOI: 10.1016/J.Bmc.2013.09.045  0.811
2013 Yedidi RS, Muhuhi JM, Liu Z, Bencze KZ, Koupparis K, O'Connor CE, Kovari IA, Spaller MR, Kovari LC. Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. Biochemical and Biophysical Research Communications. 438: 703-8. PMID 23921229 DOI: 10.1016/J.Bbrc.2013.07.117  0.839
2013 Dewdney TG, Wang Y, Kovari IA, Reiter SJ, Kovari LC. Reduced HIV-1 integrase flexibility as a mechanism for raltegravir resistance. Journal of Structural Biology. 184: 245-50. PMID 23891838 DOI: 10.1016/J.Jsb.2013.07.008  0.87
2013 Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC. Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance. Biochemical and Biophysical Research Communications. 437: 199-204. PMID 23792096 DOI: 10.1016/J.Bbrc.2013.06.027  0.849
2013 Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC. Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex. Biochemical and Biophysical Research Communications. 431: 232-8. PMID 23313846 DOI: 10.1016/J.Bbrc.2012.12.127  0.864
2013 Liu Z, Wang Y, Yedidi RS, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC. Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes. Biochemical and Biophysical Research Communications. 430: 1022-7. PMID 23261453 DOI: 10.1016/J.Bbrc.2012.12.045  0.856
2012 Wang Y, Dewdney TG, Liu Z, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC. Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease. Biology. 1: 81-93. PMID 24832048 DOI: 10.3390/Biology1010081  0.886
2012 Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 421: 413-417. PMID 22469467 DOI: 10.1016/J.Bbrc.2012.03.096  0.848
2012 Liu Z, Wang Y, Yedidi RS, Brunzelle JS, Kovari IA, Sohi J, Kamholz J, Kovari LC. Crystal structure of the extracellular domain of human myelin protein zero. Proteins. 80: 307-13. PMID 21971831 DOI: 10.1002/Prot.23164  0.72
2011 Wang Y, Liu Z, Brunzelle JS, Kovari IA, Dewdney TG, Reiter SJ, Kovari LC. The higher barrier of darunavir and tipranavir resistance for HIV-1 protease. Biochemical and Biophysical Research Communications. 412: 737-42. PMID 21871444 DOI: 10.1016/J.Bbrc.2011.08.045  0.883
2011 Yedidi RS, Proteasa G, Martinez JL, Vickrey JF, Martin PD, Wawrzak Z, Liu Z, Kovari IA, Kovari LC. Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. Acta Crystallographica. Section D, Biological Crystallography. 67: 524-32. PMID 21636892 DOI: 10.1107/S0907444911011541  0.853
2011 Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC. Nine crystal structures determine the substrate envelope of the MDR HIV-1 protease. The Protein Journal. 30: 173-83. PMID 21394574 DOI: 10.1007/S10930-011-9316-2  0.726
2011 Wang Y, Dewdney TG, Liu Z, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC. X-ray crystal structure and dynamics reveal HIV-1 protease drug interactions Studia Universitatis Babes-Bolyai Chemia. 221-230.  0.869
2010 Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents Journal of Medicinal Chemistry. 53: 4234-4247. PMID 20438064 DOI: 10.1021/Jm100233B  0.718
2005 Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. "Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target. Structure (London, England : 1993). 13: 1887-95. PMID 16338417 DOI: 10.1016/J.Str.2005.11.005  0.844
2005 Winters MA, Kagan RM, Kovari L, Heseltine PN, Merigan TC. Rare one and two amino acid inserts adjacent to codon 103 of the HIV-1 reverse transcriptase (RT) affect susceptibility to non-nucleoside RT inhibitors. Antiviral Therapy. 10: 363-6. PMID 15865232  0.485
2005 Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target Structure. 13: 1887-1895. DOI: 10.2210/Pdb1Tw7/Pdb  0.849
2004 Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC. Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity. Journal of Virology. 78: 3123-32. PMID 14990731 DOI: 10.1128/Jvi.78.6.3123-3132.2004  0.854
2003 Vickrey JF, Logsdon BC, Proteasa G, Palmer S, Winters MA, Merigan TC, Kovari LC. HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization. Protein Expression and Purification. 28: 165-72. PMID 12651121 DOI: 10.1016/S1046-5928(02)00650-2  0.872
2002 Holland-Staley CA, Kovari LC, Golenberg EM, Pobursky KJ, Mayers DL. Genetic diversity and response to IFN of the NS3 protease gene from clinical strains of the hepatitis C virus Archives of Virology. 147: 1385-1406. PMID 12111414 DOI: 10.1007/S00705-002-0807-5  0.306
2000 Winters MA, Coolley KL, Cheng P, Girard YA, Hamdan H, Kovari LC, Merigan TC. Genotypic, phenotypic, and modeling studies of a deletion in the beta3-beta4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors. Journal of Virology. 74: 10707-13. PMID 11044115 DOI: 10.1128/Jvi.74.22.10707-10713.2000  0.476
1996 Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG. Crystal structure of dimeric HIV-1 capsid protein. Nature Structural Biology. 3: 763-70. PMID 8784350 DOI: 10.1038/Nsb0996-763  0.462
1995 Kovari LC, Momany C, Rossmann MG. The use of antibody fragments for crystallization and structure determinations Structure. 3: 1291-1293. PMID 8747455 DOI: 10.1016/S0969-2126(01)00266-0  0.485
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