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Ralph M. Pollack - Publications

Affiliations: 
Biochemistry University of Maryland, Baltimore County, Baltimore, MD, United States 
Area:
Biochemistry, Pharmacology
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Wilde TC, Blotny G, Pollack RM. Experimental evidence for enzyme-enhanced coupled motion/quantum mechanical hydrogen tunneling by ketosteroid isomerase. Journal of the American Chemical Society. 130: 6577-85. PMID 18426205 DOI: 10.1021/Ja0732330  0.68
2004 Houck WJ, Pollack RM. Temperature effects on the catalytic activity of the D38E mutant of 3-oxo-Delta5-steroid isomerase: favorable enthalpies and entropies of activation relative to the nonenzymatic reaction catalyzed by acetate ion. Journal of the American Chemical Society. 126: 16416-25. PMID 15600343 DOI: 10.1021/Ja046819K  0.381
2004 Pollack RM. Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase. Bioorganic Chemistry. 32: 341-53. PMID 15381400 DOI: 10.1016/J.Bioorg.2004.06.005  0.39
2003 Houck WJ, Pollack RM. Activation enthalpies and entropies for the microscopic rate constants of acetate-catalyzed isomerization of 5-androstene-3,17-dione. Journal of the American Chemical Society. 125: 10206-12. PMID 12926942 DOI: 10.1021/Ja035957R  0.383
2001 Thornburg LD, Goldfeder YR, Wilde TC, Pollack RM. Selective catalysis of elementary steps by Asp-99 and Tyr-14 of 3-Oxo-delta(5)-steroid isomerase. Journal of the American Chemical Society. 123: 9912-3. PMID 11583562 DOI: 10.1021/Ja016683F  0.681
2000 Hénot F, Pollack RM. Catalytic activity of the D38A mutant of 3-oxo-Delta 5-steroid isomerase: recruitment of aspartate-99 as the base. Biochemistry. 39: 3351-9. PMID 10727228 DOI: 10.1021/Bi9922446  0.394
2000 Petrounia IP, Blotny G, Pollack RM. Binding of 2-naphthols to D38E mutants of 3-oxo-Delta 5-steroid isomerase: variation of ligand ionization state with the nature of the electrophilic component. Biochemistry. 39: 110-6. PMID 10625485 DOI: 10.1021/Bi9917838  0.388
1999 Pollack RM, Thornburg LD, Wu ZR, Summers MF. Mechanistic insights from the three-dimensional structure of 3-oxo-Delta(5)-steroid isomerase. Archives of Biochemistry and Biophysics. 370: 9-15. PMID 10496971 DOI: 10.1006/Abbi.1999.1384  0.395
1999 Yao X, Pollack RM. Electronic effects on enol acidity and keto-enol equilibrium constants for ring-substituted 2-tetralones Canadian Journal of Chemistry. 77: 634-638. DOI: 10.1139/V99-006  0.491
1999 Yao X, Gold MA, Pollack RM. Transition State Imbalance in Proton Transfer from Phenyl Ring-Substituted 2-Tetralones to Acetate Ion Journal of the American Chemical Society. 121: 6220-6225. DOI: 10.1021/Ja990070+  0.512
1998 Thornburg LD, Hénot F, Bash DP, Hawkinson DC, Bartel SD, Pollack RM. Electrophilic assistance by Asp-99 of 3-Oxo-Δ5-steroid isomerase Biochemistry. 37: 10499-10506. PMID 9671521 DOI: 10.1021/Bi980099A  0.355
1998 Qi L, Pollack RM. Catalytic contribution of phenylalanine-101 of 3-oxo-Delta 5-steroid isomerase. Biochemistry. 37: 6760-6. PMID 9578560 DOI: 10.1021/Bi972745W  0.364
1998 Petrounia IP, Pollack RM. Substituent effects on the binding of phenols to the D38N mutant of 3-oxo-delta5-steroid isomerase. A probe for the nature of hydrogen bonding to the intermediate. Biochemistry. 37: 700-5. PMID 9425094 DOI: 10.1021/Bi972262S  0.36
1998 Blotny G, Pollack RM. Synthesis of 5,7- and 6,7-Dinitro-2-Tetralones Synthetic Communications. 28: 3865-3875. DOI: 10.1080/00397919808004940  0.307
1997 Wu ZR, Ebrahimian S, Zawrotny ME, Thornburg LD, Perez-Alvarado GC, Brothers P, Pollack RM, Summers MF. Solution structure of 3-oxo-delta5-steroid isomerase. Science (New York, N.Y.). 276: 415-8. PMID 9103200 DOI: 10.1126/Science.276.5311.415  0.378
1997 Nevy JB, Hawkinson DC, Blotny G, Yao X, Pollack RM. Transition state imbalance in the deprotonation of substituted 2- tetralones by hydroxide ion Journal of the American Chemical Society. 119: 12722-12726. DOI: 10.1021/Ja972600C  0.477
1996 Zawrotny ME, Hawkinson DC, Blotny G, Pollack RM. Mechanism of proton transfer in the isomerization of 5-androstene-3,17-dione by 3-Oxo-δ5-steroid isomerase and Its D38E mutant Biochemistry. 35: 6438-6442. PMID 8639590 DOI: 10.1021/Bi953025X  0.342
1996 Brothers PN, Blotny G, Qi L, Pollack RM. An active site phenylalanine of 3-oxo-delta 5-steroid isomerase is catalytically important for proton transfer. Biochemistry. 34: 15453-8. PMID 7492546 DOI: 10.1021/Bi00047A009  0.392
1994 Zawrotny ME, Pollack RM. Reaction energetics of a mutant 3-oxo-delta 5-steroid isomerase with an altered active site base (D38E). Biochemistry. 33: 13896-902. PMID 7947798 DOI: 10.1021/Bi00250A044  0.378
1993 Hawkinson DC, Pollack RM. Is a proton relay involved in the mechanism of 3-oxo-Δ5-steroid isomerase? Biochemistry. 32: 694-698. PMID 8093664 DOI: 10.1021/Bi00053A038  0.306
1993 Eldin S, Whalen DL, Pollack RM. Structural effects on charge delocalization in benzylic anions The Journal of Organic Chemistry. 58: 3490-3495. DOI: 10.1021/Jo00065A007  0.329
1992 Zeng BF, Bounds PL, Steiner RF, Pollack RM. Nature of the intermediate in the 3-oxo-delta 5-steroid isomerase reaction. Biochemistry. 31: 1521-8. PMID 1346570 DOI: 10.1021/Bi00120A032  0.4
1991 Hawkinson DC, Eames TC, Pollack RM. Energetics of 3-oxo-delta 5-steroid isomerase: source of the catalytic power of the enzyme. Biochemistry. 30: 10849-58. PMID 1932007 DOI: 10.1021/Bi00109A007  0.361
1991 Hawkinson DC, Eames TC, Pollack RM. Kinetic competence of an externally generated dienol intermediate with steroid isomerase. Biochemistry. 30: 6956-64. PMID 1676914 DOI: 10.1021/Bi00242A021  0.381
1991 Zeng B, Pollack RM. Microscopic rate constants for the acetate ion catalyzed isomerization of 5-androstene-3,17-dione to 4-androstene-3,17-dione: a model for steroid isomerase Journal of the American Chemical Society. 113: 3838-3842. DOI: 10.1021/Ja00010A028  0.377
1991 Eldin S, Pollack RM, Whalen DL. Structural effects on the rates of formation and the stability of enols of cyclic benzyl ketones Journal of the American Chemical Society. 113: 1344-1349. DOI: 10.1021/Ja00004A041  0.353
1990 Dzingeleski GD, Blotny G, Pollack RM. Kinetics of the acetate ion catalyzed ketonization of 1,3-cyclohexadienol: equilibrium constants for the enolization of 2- and 3-cyclohexenone The Journal of Organic Chemistry. 55: 1019-1023. DOI: 10.1021/Jo00290A038  0.362
1989 Eames TC, Pollack RM, Steiner RF. Orientation, accessibility, and mobility of equilenin bound to the active site of steroid isomerase. Biochemistry. 28: 6269-75. PMID 2675967 DOI: 10.1021/Bi00441A019  0.326
1989 Pollack RM, Zeng B, Mack JPG, Eldin S. Determination of the microscopic rate constants for the base catalyzed conjugation of 5-androstene-3,17-dione Journal of the American Chemical Society. 111: 6419-6423. DOI: 10.1021/Ja00198A066  0.32
1988 Dzingeleski GD, Bantia S, Blotny G, Pollack RM. Kinetics and mechanism of the ketonization of a conjugated trienol The Journal of Organic Chemistry. 53: 1540-1544. DOI: 10.1021/Jo00242A038  0.324
1987 Bounds PL, Pollack RM. Affinity alkylation of 3-oxo-delta 5-steroid isomerase by steroidal 3 beta-oxiranes: identification of the modified amino acid by reduction with hydroxyborohydride. Biochemistry. 26: 2263-9. PMID 3620446 DOI: 10.1021/Bi00382A029  0.316
1987 Pollack RM, Mack JPG, Eldin S. Direct observation of a dienolate intermediate in the base-catalyzed isomerization of 5-androstene-3,17-dione to 4-androstene-3,17-dione Journal of the American Chemical Society. 109: 5048-5050. DOI: 10.1021/Ja00250A061  0.366
1987 Pollack RM, Mack JPG, Blotny G. Ketonization of 1,3-cyclohexadienol, a conjugated enol Journal of the American Chemical Society. 109: 3138-3139. DOI: 10.1021/Ja00244A042  0.312
1986 Bevins CL, Pollack RM, Kayser RH, Bounds PL. Detection of a transient enzyme-steroid complex during active-site-directed irreversible inhibition of 3-oxo-delta 5-steroid isomerase. Biochemistry. 25: 5159-64. PMID 3768338 DOI: 10.1021/Bi00366A026  0.362
1986 Pollack RM, Bantia S, Bounds PL, Koffman BM. pH dependence of the kinetic parameters for 3-oxo-delta 5-steroid isomerase. Substrate catalysis and inhibition by (3S)-spiro[5 alpha-androstane-3,2'-oxiran]-17-one. Biochemistry. 25: 1905-11. PMID 3707917 DOI: 10.1021/Bi00356A011  0.37
1986 Bantia S, Pollack RM. Evidence for an enol intermediate in the 3-oxo-.DELTA.5-steroid isomerase catalyzed isomerization of .DELTA.5 ketones Journal of the American Chemical Society. 108: 3145-3146. DOI: 10.1021/Ja00271A076  0.398
1985 Bantia S, Bevins CL, Pollack RM. Mechanism of inactivation of 3-oxosteroid delta 5-isomerase by 17 beta-oxiranes. Biochemistry. 24: 2606-9. PMID 4027215 DOI: 10.1021/Bi00332A003  0.384
1984 Bevins CL, Bantia S, Pollack RM, Bounds PL, Kayser RH. Modification of an enzyme carboxylate residue in the inhibition of 3-oxo-.DELTA.5-steroid isomerase by (3S)-spiro[5.alpha.-androstane-3,2'-oxirane]-17.beta.-ol. Implications for the mechanism of action Journal of the American Chemical Society. 106: 4957-4962. DOI: 10.1021/Ja00329A055  0.355
1984 Pollack RM, Kayser RH, Cashen MJ. Rates of acid- and base-catalyzed enolization of trans-hexahydrofluorenone. Concerning stereoelectronic control of enolization The Journal of Organic Chemistry. 49: 3983-3987. DOI: 10.1002/Chin.198515101  0.318
1983 Kayser RH, Brault M, Pollack RM, Bantia S, Sadoff SF. Kinetics of decarboxylation of the two epimers of 5-tert-butyl-1-methyl-2-oxocyclohexanecarboxlic acid: lack of stereoelectronic control in .beta.-keto acid decarboxylation The Journal of Organic Chemistry. 48: 4497-4502. DOI: 10.1021/Jo00172A011  0.318
1980 Bevins CL, Kayser RH, Pollack RM, Ekiko DB, Sadoff S. Irreversible active-site-directed inhibition of delta 5-3-ketosteroid isomerase by steroidal 17-beta-oxiranes. Evidence for two modes of binding in steroid-enzyme complexes. Biochemical and Biophysical Research Communications. 95: 1131-7. PMID 7417304 DOI: 10.1016/0006-291X(80)91590-9  0.324
1979 Pollack RM, Kayser RH, Bevins CL. An active-site-directed irreversible inhibitor of delta 5-3-ketosteroid isomerase. Biochemical and Biophysical Research Communications. 91: 783-90. PMID 526282 DOI: 10.1016/0006-291X(79)91948-X  0.306
1977 Kayser RH, Pollack RM. Formation of .alpha.,.beta.-unsaturated Schiff bases from .beta.,.gamma.-unsaturated ketones. A change in rate-determining step in the reactions of 3-methyl-3-cyclohexenone with glycinamide and ethylenediamine The Journal of Organic Chemistry. 42: 2088-2091. DOI: 10.1021/Jo00432A011  0.343
1977 Pollack RM, Kayser RH, Damewood JR. The effect of solvent on intramolecular general base catalysis in the hydrolysis of .alpha.,.beta.-unsaturated Schiff bases Journal of the American Chemical Society. 99: 8232-8237. DOI: 10.1021/Ja00467A018  0.327
1976 Brault M, Pollack RM, Bevins CL. Kinetics and mechanism of the hydrolysis of 2,2,2-trifluoro-N-(3-methyl-2-cyclohexenylidene)ethylamine. .alpha.,.beta.-Unsaturated Schiff base The Journal of Organic Chemistry. 41: 346-350. DOI: 10.1021/Jo00864A035  0.311
1976 Pollack RM, Kayser RH. Trifluoroethylamine-catalyzed isomerization of .beta.,.gamma.-unsaturated ketones. Nucleophilic catalysis via Schiff base formation Journal of the American Chemical Society. 98: 4174-4181. DOI: 10.1021/Ja00430A028  0.34
1975 Kayser RH, Pollack RM. Letter: Primary amine cytalysis of the isomerization of a beta, gamma-unsatureate ketone to its alpha, beta-unsaturated isomer. A possible model for enzymatic double bone migration in unsaturated ketones. Journal of the American Chemical Society. 97: 952-3. PMID 1133376 DOI: 10.1021/Ja00837A076  0.305
1975 Pollack RM, Dumsha TC. Imidazole-catalyzed hydrolysis of anilides. Nucleophilic catalysis or proton-transfer catalysis Journal of the American Chemical Society. 97: 377-380. DOI: 10.1021/Ja00835A027  0.364
1974 Vitullo VP, Pollack RM, Faith WC, Keiser ML. Substituent effects in acetal hydrolysis Journal of the American Chemical Society. 96: 6682-6685. DOI: 10.1021/Ja00828A023  0.338
1973 Philipp M, Pollack RM, Bender ML. Influence of Leaving-Group Electronic Effect on alpha-Chymotrypsin: Catalytic Constants of Specific Substrates. Proceedings of the National Academy of Sciences of the United States of America. 70: 517-20. PMID 16592059 DOI: 10.1073/Pnas.70.2.517  0.361
1969 Noyce DS, Pollack RM. The mechanisms for the acid-catalyzed hydrolysis of vinyl acetate and isopropenyl acetate Journal of the American Chemical Society. 91: 7158-7163. DOI: 10.1021/Ja01053A045  0.336
1969 Noyce DS, Pollack RM. Two mechanisms for the acid-catalyzed hydrolysis of enol acetates Journal of the American Chemical Society. 91: 119-124. DOI: 10.1021/Ja01029A025  0.338
1968 Noyce DS, Hartter DR, Pollack RM. The mechanism of the acid-catalyzed dehydration of 1,2-diphenylethanol Journal of the American Chemical Society. 90: 3791-3794. DOI: 10.1021/Ja01016A034  0.315
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