| Year |
Citation |
Score |
| 2023 |
Kollet O, Das A, Karamanos N, Auf dem Keller U, Sagi I. Redefining metalloproteases specificity through network proteolysis. Trends in Molecular Medicine. PMID 38036391 DOI: 10.1016/j.molmed.2023.11.001 |
0.35 |
|
| 2021 |
Mohan V, Gaffney JP, Solomonov I, Levin M, Klepfish M, Akbareian S, Grünwald B, Dym O, Eisenstein M, Yu KH, Kelsen DP, Krüger A, Edwards DR, Sagi I. Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill. Cancers. 13. PMID 33918254 DOI: 10.3390/cancers13071679 |
0.359 |
|
| 2020 |
Naik S, Unni M, Sinha D, Rajput SS, Reddy PC, Kartvelishvily E, Solomonov I, Sagi I, Chatterji A, Patil S, Galande S. Differential tissue stiffness of body column facilitates locomotion of on solid substrates. The Journal of Experimental Biology. PMID 32958523 DOI: 10.1242/Jeb.232702 |
0.315 |
|
| 2020 |
Klepfish M, Gross T, Vugman M, Afratis NA, Havusha-Laufer S, Brazowski E, Solomonov I, Varol C, Sagi I. LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis. Frontiers in Immunology. 11: 480. PMID 32296422 DOI: 10.3389/Fimmu.2020.00480 |
0.369 |
|
| 2020 |
Cohen L, Sagi I, Bigelman E, Solomonov I, Aloshin A, Ben-Shoshan J, Rozenbaum Z, Keren G, Entin-Meer M. Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody. Plos One. 15: e0231202. PMID 32271823 DOI: 10.1371/Journal.Pone.0231202 |
0.389 |
|
| 2020 |
Levi N, Papismadov N, Solomonov I, Sagi I, Krizhanovsky V. The ECM path of senescence in aging: components and modifiers. The Febs Journal. PMID 32145148 DOI: 10.1111/Febs.15282 |
0.346 |
|
| 2019 |
Das A, Mohan V, Krishnaswamy VR, Solomonov I, Sagi I. Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression. Cancer Metastasis Reviews. PMID 31773432 DOI: 10.1007/S10555-019-09813-5 |
0.371 |
|
| 2019 |
Mohan V, Das A, Sagi I. Emerging roles of ECM remodeling processes in cancer. Seminars in Cancer Biology. PMID 31518697 DOI: 10.1016/J.Semcancer.2019.09.004 |
0.35 |
|
| 2019 |
Shabat D, Hananya N, Press O, Das A, Scomparin A, Satchi-Fainaro R, Sagi I. Persistent Chemiluminescent Glow of Phenoxy-Dioxetane Luminophore Enables Unique CRET-Based Detection of Proteases. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31495978 DOI: 10.1002/Chem.201903489 |
0.367 |
|
| 2019 |
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801371R. PMID 31381863 DOI: 10.1096/Fj.201801371R |
0.314 |
|
| 2019 |
Krishnaswamy VR, Benbenishty A, Blinder P, Sagi I. Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights. Cellular and Molecular Life Sciences : Cmls. PMID 31197404 DOI: 10.1007/S00018-019-03182-6 |
0.346 |
|
| 2019 |
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, ... ... Sagi I, et al. ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer. Embo Molecular Medicine. PMID 30833304 DOI: 10.15252/Emmm.201809976 |
0.3 |
|
| 2019 |
Afratis NA, Sagi I. Novel Approaches for Extracellular Matrix Targeting in Disease Treatment. Methods in Molecular Biology (Clifton, N.J.). 1952: 261-275. PMID 30825181 DOI: 10.1007/978-1-4939-9133-4_21 |
0.437 |
|
| 2018 |
Sapoznikov A, Gal Y, Falach R, Sagi I, Ehrlich S, Lerer E, Makovitzki A, Aloshin A, Kronman C, Sabo T. Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30382767 DOI: 10.1152/Ajplung.00300.2018 |
0.333 |
|
| 2018 |
Afratis NA, Klepfish M, Karamanos NK, Sagi I. The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: applications to drug discovery. Advanced Drug Delivery Reviews. PMID 29627371 DOI: 10.1016/J.Addr.2018.03.004 |
0.433 |
|
| 2018 |
Afratis NA, Selman M, Pardo A, Sagi I. Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29428229 DOI: 10.1016/J.Matbio.2018.02.007 |
0.406 |
|
| 2018 |
Cohen L, Bigelman E, Sagi I, Keren G, Entin-Meer M. P2821Specific MMP-9 and MMP-2 inhibition by novel MMP antibody attenuates LV remodeling secondary to volume overload European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy565.P2821 |
0.387 |
|
| 2017 |
Varol C, Sagi I. Phagocyte - extracellular matrix crosstalk empowers tumour development and dissemination. The Febs Journal. PMID 29106767 DOI: 10.1111/Febs.14317 |
0.366 |
|
| 2017 |
Decaneto E, Vasilevskaya T, Kutin Y, Ogata H, Grossman M, Sagi I, Havenith M, Lubitz W, Thiel W, Cox N. Solvent water interactions within the active site of the membrane type I matrix metalloproteinase. Physical Chemistry Chemical Physics : Pccp. PMID 28951896 DOI: 10.1039/C7Cp05572B |
0.419 |
|
| 2017 |
Weizman T, Levin I, Zaretsky M, Sagi I, Aharoni A. Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting. Frontiers in Molecular Biosciences. 4: 61. PMID 28879185 DOI: 10.3389/Fmolb.2017.00061 |
0.36 |
|
| 2017 |
Krishnaswamy VR, Mintz D, Sagi I. Matrix metalloproteinases: The sculptors of chronic cutaneous wounds. Biochimica Et Biophysica Acta. PMID 28797647 DOI: 10.1016/J.Bbamcr.2017.08.003 |
0.362 |
|
| 2017 |
Levin M, Udi Y, Solomonov I, Sagi I. Next Generation Matrix Metalloproteinase Inhibitors - Novel Strategies Bring New Prospects. Biochimica Et Biophysica Acta. PMID 28636874 DOI: 10.1016/J.Bbamcr.2017.06.009 |
0.473 |
|
| 2017 |
Arkadash V, Yosef G, Shirian J, Cohen I, Horev Y, Grossman M, Sagi I, Radisky ES, Shifman JM, Papo N. Development of high-affinity and high-specificity inhibitors of metalloproteinase 14 through computational design and directed evolution. The Journal of Biological Chemistry. PMID 28087697 DOI: 10.1074/Jbc.M116.756718 |
0.438 |
|
| 2016 |
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, Yaron A, Milla ME, Sagi I. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Scientific Reports. 6: 35598. PMID 27982031 DOI: 10.1038/Srep35598 |
0.756 |
|
| 2016 |
Talmi-Frank D, Altboum Z, Solomonov I, Udi Y, Jaitin DA, Klepfish M, David E, Zhuravlev A, Keren-Shaul H, Winter DR, Gat-Viks I, Mandelboim M, Ziv T, Amit I, Sagi I. Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality. Cell Host & Microbe. 20: 458-470. PMID 27736644 DOI: 10.1016/J.Chom.2016.09.005 |
0.367 |
|
| 2016 |
Afik R, Zigmond E, Vugman M, Klepfish M, Shimshoni E, Pasmanik-Chor M, Shenoy A, Bassat E, Halpern Z, Geiger T, Sagi I, Varol C. Tumor macrophages are pivotal constructors of tumor collagenous matrix. The Journal of Experimental Medicine. PMID 27697834 DOI: 10.1084/Jem.20151193 |
0.324 |
|
| 2016 |
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A. ADAM17 substrate release in proximal tubule drives kidney fibrosis. Jci Insight. 1. PMID 27642633 DOI: 10.1172/Jci.Insight.87023 |
0.731 |
|
| 2016 |
Solomonov I, Zehorai E, Talmi-Frank D, Wolf SG, Shainskaya A, Zhuravlev A, Kartvelishvily E, Visse R, Levin Y, Kampf N, Jaitin DA, David E, Amit I, Nagase H, Sagi I. Distinct biological events generated by ECM proteolysis by two homologous collagenases. Proceedings of the National Academy of Sciences of the United States of America. PMID 27630193 DOI: 10.1073/Pnas.1519676113 |
0.408 |
|
| 2016 |
Grossman M, Ben-Chetrit N, Zhuravlev A, Afik R, Bassat E, Solomonov I, Yarden Y, Sagi I. Tumor cell invasion can be blocked by modulators of collagen fibril alignment that control assembly of the extracellular matrix. Cancer Research. PMID 27221706 DOI: 10.1158/0008-5472.Can-15-2813 |
0.378 |
|
| 2016 |
Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, et al. Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nature Medicine. 22: 446. PMID 27050594 DOI: 10.1038/Nm0416-446B |
0.711 |
|
| 2016 |
Gur-Cohen S, Avemaria F, Kollet O, Avci S, Itkin T, Ramasamy SK, Kusumbe AP, Golan K, Khatib-Massalha E, Kumari A, Carolina MM, Lin W, Yu Q, Wu H, Zeng YA, ... ... Sagi I, et al. EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance Blood. 128: 4538-4538. DOI: 10.1182/Blood.V128.22.4538.4538 |
0.308 |
|
| 2016 |
Elad N, Bellapadrona G, Houben L, Sagi I, Elbaum M. Detection of Zn Atoms on Ferritin by Annular Dark-Field cryo-STEM Biophysical Journal. 110: 155a-156a. DOI: 10.1016/J.Bpj.2015.11.874 |
0.325 |
|
| 2015 |
Tsukerman P, Eisenstein EM, Chavkin M, Schmiedel D, Wong E, Werner M, Yaacov B, Averbuch D, Molho-Pessach V, Stepensky P, Kaynan N, Bar-On Y, Seidel E, Yamin R, Sagi I, et al. Cytokine secretion and NK cell activity in human ADAM17 deficiency. Oncotarget. 6: 44151-60. PMID 26683521 DOI: 10.18632/Oncotarget.6629 |
0.725 |
|
| 2015 |
Cohen SG, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, et al. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nature Medicine. PMID 26457757 DOI: 10.1038/Nm.3960 |
0.73 |
|
| 2015 |
Wong E, Maretzky T, Peleg Y, Blobel CP, Sagi I. The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site. The Journal of Biological Chemistry. 290: 12135-46. PMID 25795784 DOI: 10.1074/Jbc.M114.624072 |
0.747 |
|
| 2015 |
Gaffney J, Solomonov I, Zehorai E, Sagi I. Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo. Matrix Biology : Journal of the International Society For Matrix Biology. 44: 191-9. PMID 25622911 DOI: 10.1016/J.Matbio.2015.01.012 |
0.433 |
|
| 2015 |
Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I. Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure (London, England : 1993). 23: 104-15. PMID 25482542 DOI: 10.1016/J.Str.2014.10.012 |
0.434 |
|
| 2015 |
Shimshoni E, Yablecovitch D, Baram L, Dotan I, Sagi I. ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation. Gut. 64: 367-72. PMID 25416065 DOI: 10.1136/Gutjnl-2014-308048 |
0.326 |
|
| 2015 |
Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Froeyen M, Deryugina EI, Quigley JP, Moestrup SK, ... ... Sagi I, et al. Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1. The Biochemical Journal. 465: 259-70. PMID 25360794 DOI: 10.1042/Bj20140418 |
0.469 |
|
| 2015 |
Gur Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Golan K, Kalinkovich A, Esmon CT, Ruf W, Sagi I, Erez A, Lapidot T. EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels Blood. 126: 33-33. DOI: 10.1182/Blood.V126.23.33.33 |
0.319 |
|
| 2015 |
Plaks V, Chou J, Maynard C, Nguyen NH, Kong N, Solomonov I, Talmi-Frank D, Bonnans C, Sagi I, Werb Z. Abstract 4724: Targeting matrix metalloproteinases (MMP) for anti-metastatic therapy: Blocking active MMP9 abrogates metastatic niche formation and prevents metastatic seeding in a breast cancer model Cancer Research. 75: 4724-4724. DOI: 10.1158/1538-7445.Am2015-4724 |
0.4 |
|
| 2014 |
Dielmann-Gessner J, Grossman M, Conti Nibali V, Born B, Solomonov I, Fields GB, Havenith M, Sagi I. Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state. Proceedings of the National Academy of Sciences of the United States of America. 111: 17857-62. PMID 25425663 DOI: 10.1073/Pnas.1410144111 |
0.367 |
|
| 2014 |
Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A. ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. Nature Communications. 5: 4058. PMID 24898499 DOI: 10.1038/Ncomms5058 |
0.704 |
|
| 2014 |
Sharabi O, Shirian J, Grossman M, Lebendiker M, Sagi I, Shifman J. Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs. Plos One. 9: e93712. PMID 24710006 DOI: 10.1371/Journal.Pone.0093712 |
0.402 |
|
| 2014 |
Ogata H, Decaneto E, Grossman M, Havenith M, Sagi I, Lubitz W, Knipp M. Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase. Acta Crystallographica. Section F, Structural Biology Communications. 70: 232-5. PMID 24637763 DOI: 10.1107/S2053230X13034857 |
0.362 |
|
| 2014 |
Fragai M, Luchinat C, Martelli T, Ravera E, Sagi I, Solomonov I, Udi Y. SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detail. Chemical Communications (Cambridge, England). 50: 421-3. PMID 24248259 DOI: 10.1039/C3Cc46896H |
0.306 |
|
| 2013 |
Udi Y, Fragai M, Grossman M, Mitternacht S, Arad-Yellin R, Calderone V, Melikian M, Toccafondi M, Berezovsky IN, Luchinat C, Sagi I. Unraveling hidden regulatory sites in structurally homologous metalloproteases. Journal of Molecular Biology. 425: 2330-46. PMID 23583775 DOI: 10.1016/J.Jmb.2013.04.009 |
0.452 |
|
| 2013 |
Cohen SG, Itkin T, Ludin A, Chakrabarty S, Kollet O, Golan K, Kalinkovich A, Wong E, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling Blood. 122: 795-795. DOI: 10.1182/Blood.V122.21.795.795 |
0.741 |
|
| 2013 |
Born B, Heyden M, Grossman M, Sagi I, Havenith M. Protein-water network dynamics during metalloenzyme hydrolysis observed by kinetic THz absorption (KITA) Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8585. DOI: 10.1117/12.2000715 |
0.332 |
|
| 2012 |
Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. The Journal of Biological Chemistry. 287: 20555-64. PMID 22528492 DOI: 10.1074/Jbc.M112.344036 |
0.306 |
|
| 2012 |
Sela-Passwell N, Kikkeri R, Dym O, Rozenberg H, Margalit R, Arad-Yellin R, Eisenstein M, Brenner O, Shoham T, Danon T, Shanzer A, Sagi I. Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential. Nature Medicine. 18: 143-7. PMID 22198278 DOI: 10.1038/Nm.2582 |
0.772 |
|
| 2012 |
Born B, Sagi I, Havenith M. Water's contribution and enzyme's work: A KITA study Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8225. DOI: 10.1117/12.907770 |
0.337 |
|
| 2011 |
Sela-Passwell N, Trahtenherts A, Krüger A, Sagi I. New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology. Expert Opinion On Drug Discovery. 6: 527-42. PMID 22646077 DOI: 10.1517/17460441.2011.560936 |
0.782 |
|
| 2011 |
Shechter R, Raposo C, London A, Sagi I, Schwartz M. The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair. Plos One. 6: e27969. PMID 22205935 DOI: 10.1371/Journal.Pone.0027969 |
0.355 |
|
| 2011 |
Grossman M, Sela-Passwell N, Sagi I. Achieving broad molecular insights into dynamic protein interactions by integrated structural-kinetic approaches. Current Opinion in Structural Biology. 21: 678-85. PMID 21945040 DOI: 10.1016/J.Sbi.2011.07.008 |
0.741 |
|
| 2011 |
Grossman M, Born B, Heyden M, Tworowski D, Fields GB, Sagi I, Havenith M. Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site. Nature Structural & Molecular Biology. 18: 1102-8. PMID 21926991 DOI: 10.1038/Nsmb.2120 |
0.367 |
|
| 2011 |
Kaminker I, Sushenko A, Potapov A, Daube S, Akabayov B, Sagi I, Goldfarb D. Probing conformational variations at the ATPase site of the RNA helicase DbpA by high-field electron-nuclear double resonance spectroscopy. Journal of the American Chemical Society. 133: 15514-23. PMID 21819147 DOI: 10.1021/Ja204291D |
0.3 |
|
| 2011 |
Orgel JPRO, Antipova O, Sagi I, Bitler A, Qiu D, Wang R, Xu Y, San Antonio JD. Collagen fibril surface displays a constellation of sites capable of promoting fibril assembly, stability, and hemostasis Connective Tissue Research. 52: 18-24. PMID 21117898 DOI: 10.3109/03008207.2010.511354 |
0.343 |
|
| 2010 |
Rosenblum G, Van den Steen PE, Cohen SR, Bitler A, Brand DD, Opdenakker G, Sagi I. Direct visualization of protease action on collagen triple helical structure. Plos One. 5: e11043. PMID 20585385 DOI: 10.1371/Journal.Pone.0011043 |
0.703 |
|
| 2010 |
Grossman M, Tworowski D, Dym O, Lee MH, Levy Y, Murphy G, Sagi I. The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function. Biochemistry. 49: 6184-92. PMID 20545310 DOI: 10.1021/Bi902141X |
0.438 |
|
| 2010 |
Rouffet M, de Oliveira CA, Udi Y, Agrawal A, Sagi I, McCammon JA, Cohen SM. From sensors to silencers: quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases. Journal of the American Chemical Society. 132: 8232-3. PMID 20507095 DOI: 10.1021/Ja101088J |
0.366 |
|
| 2010 |
Sela-Passwell N, Rosenblum G, Shoham T, Sagi I. Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition? Biochimica Et Biophysica Acta. 1803: 29-38. PMID 19406173 DOI: 10.1016/J.Bbamcr.2009.04.010 |
0.775 |
|
| 2010 |
Bitler A, Perugia E, Solomonov I, Visse R, Orgel J, Nagase H, Cohen S, Sagi I. Influence of Matrix Metalloprotease on the Flexibility of Type I Collagen Fibrils Studied By Atomic Force Microscopy Biophysical Journal. 98: 29a. DOI: 10.1016/J.Bpj.2009.12.172 |
0.332 |
|
| 2008 |
Sagi I, Milla ME. Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme. Analytical Biochemistry. 372: 1-10. PMID 17963710 DOI: 10.1016/J.Ab.2007.07.037 |
0.443 |
|
| 2007 |
Rosenblum G, Van den Steen PE, Cohen SR, Grossmann JG, Frenkel J, Sertchook R, Slack N, Strange RW, Opdenakker G, Sagi I. Insights into the Structure and Domain Flexibility of Full-Length Pro-Matrix Metalloproteinase-9/Gelatinase B Structure. 15: 1227-1236. PMID 17937912 DOI: 10.1016/J.Str.2007.07.019 |
0.688 |
|
| 2007 |
Rosenblum G, Meroueh S, Toth M, Fisher JF, Fridman R, Mobashery S, Sagi I. Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: Challenging the cysteine switch dogma Journal of the American Chemical Society. 129: 13566-13574. PMID 17929919 DOI: 10.1021/Ja073941L |
0.715 |
|
| 2007 |
Solomon A, Akabayov B, Frenkel A, Milla ME, Sagi I. Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. Proceedings of the National Academy of Sciences of the United States of America. 104: 4931-6. PMID 17360351 DOI: 10.1073/Pnas.0700066104 |
0.378 |
|
| 2006 |
Talavera MA, Matthews EE, Eliason WK, Sagi I, Wang J, Henn A, De La Cruz EM. Hydrodynamic characterization of the DEAD-box RNA helicase DbpA. Journal of Molecular Biology. 355: 697-707. PMID 16325852 DOI: 10.1016/J.Jmb.2005.10.058 |
0.307 |
|
| 2005 |
Akabayov B, Doonan CJ, Pickering IJ, George GN, Sagi I. Using softer X-ray absorption spectroscopy to probe biological systems. Journal of Synchrotron Radiation. 12: 392-401. PMID 15968114 DOI: 10.1107/S0909049505010150 |
0.336 |
|
| 2004 |
Kleifeld O, Rulísek L, Bogin O, Frenkel A, Havlas Z, Burstein Y, Sagi I. Higher metal-ligand coordination in the catalytic site of cobalt-substituted Thermoanaerobacter brockii alcohol dehydrogenase lowers the barrier for enzyme catalysis. Biochemistry. 43: 7151-61. PMID 15170352 DOI: 10.1021/Bi0302696 |
0.616 |
|
| 2004 |
Solomon A, Rosenblum G, Gonzales PE, Leonard JD, Mobashery S, Milla ME, Sagi I. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-α-converting enzyme and matrix metalloproteinases despite their high structural similarity Journal of Biological Chemistry. 279: 31646-31654. PMID 15102849 DOI: 10.1074/Jbc.M401310200 |
0.711 |
|
| 2004 |
Gonzales PE, Solomon A, Miller AB, Leesnitzer MA, Sagi I, Milla ME. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. The Journal of Biological Chemistry. 279: 31638-45. PMID 15100227 DOI: 10.1074/Jbc.M401311200 |
0.359 |
|
| 2003 |
Rosenblum G, Meroueh SO, Kleifeld O, Brown S, Singson SP, Fridman R, Mobashery S, Sagi I. Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2) Journal of Biological Chemistry. 278: 27009-27015. PMID 12679334 DOI: 10.1074/Jbc.M301139200 |
0.774 |
|
| 2003 |
Kleifeld O, Shi SP, Zarivach R, Eisenstein M, Sagi I. The conserved Glu-60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis. Protein Science : a Publication of the Protein Society. 12: 468-79. PMID 12592017 DOI: 10.1110/Ps.0221603 |
0.614 |
|
| 2003 |
Kleifeld O, Frenkel A, Martin JM, Sagi I. Active site electronic structure and dynamics during metalloenzyme catalysis. Nature Structural Biology. 10: 98-103. PMID 12524531 DOI: 10.1038/Nsb889 |
0.617 |
|
| 2002 |
Federman S, Miller LM, Sagi I. Following matrix metalloproteinases activity near the cell boundary by infrared micro-spectroscopy. Matrix Biology : Journal of the International Society For Matrix Biology. 21: 567-77. PMID 12475641 DOI: 10.1016/S0945-053X(02)00089-6 |
0.436 |
|
| 2002 |
Sagi I, Rosenblum G, Kleifeld O, Frenkel A. Time resolved X-ray absorption spectroscopy studies of metalloenzymes reveal mechanistic information beyond kinetics Acta Crystallographica Section a Foundations of Crystallography. 58: c188-c188. DOI: 10.1107/S0108767302092553 |
0.541 |
|
| 2002 |
Frenkel AI, Kleifeld O, Wasserman SR, Sagi I. Phase speciation by extended x-ray absorption fine structure spectroscopy Journal of Chemical Physics. 116: 9449-9456. DOI: 10.1063/1.1473193 |
0.547 |
|
| 2002 |
Cheng F, Zhang R, Luo X, Shen J, Li X, Gu J, Zhu W, Sagi I, Ji R, Chen K, Jiang H. Quantum chemistry study on the interaction of the exogenous ligands and the catalytic zinc ion in matrix metalloproteinases Journal of Physical Chemistry B. 106: 4552-4559. DOI: 10.1021/Jp013336J |
0.428 |
|
| 2001 |
Kleifeld O, Frenkel A, Sagi I. Time-dependent XAS studies of trapped enzyme-substrate complexes of alcohol dehydrogenase from Thermoanaerobacter brockii. Journal of Synchrotron Radiation. 8: 978-80. PMID 11513000 DOI: 10.1107/S0909049500017684 |
0.609 |
|
| 2001 |
Kleifeld O, Kotra LP, Gervasi DC, Brown S, Bernardo MM, Fridman R, Mobashery S, Sagi I. X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. The Journal of Biological Chemistry. 276: 17125-31. PMID 11278946 DOI: 10.1074/Jbc.M011604200 |
0.689 |
|
| 2000 |
Kleifeld O, Van den Steen PE, Frenkel A, Cheng F, Jiang HL, Opdenakker G, Sagi I. Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils. The Journal of Biological Chemistry. 275: 34335-43. PMID 10938090 DOI: 10.1074/Jbc.M005714200 |
0.65 |
|
| 2000 |
Kleifeld O, Frenkel A, Bogin O, Eisenstein M, Brumfeld V, Burstein Y, Sagi I. Spectroscopic studies of inhibited alcohol dehydrogenase from Thermoanaerobacter brockii: proposed structure for the catalytic intermediate state. Biochemistry. 39: 7702-11. PMID 10869175 DOI: 10.1021/Bi0002030 |
0.625 |
|
| 1998 |
Sagi I, Hochman Y, Bunker G, Carmeli S, Carmeli C. Structure function relationship of vanadate bound to a single site in chloroplast CF1-ATPase as determined by X-ray absorption Photosynthesis Research. 57: 275-285. DOI: 10.1023/A:1006020813909 |
0.354 |
|
| 1992 |
Chance MR, Sagi I, Wirt MD, Frisbie SM, Scheuring E, Chen E, Bess JW, Henderson LE, Arthur LO, South TL, Ferez-Alvarado G, Summers MF. Extended x-ray absorption fine structure studies of a retrovirus: Equine infectious anemia virus cysteine arrays are coordinated to zinc Proceedings of the National Academy of Sciences of the United States of America. 89: 10041-10045. PMID 1332027 DOI: 10.1073/Pnas.89.21.10041 |
0.31 |
|
| 1992 |
Summers MF, Henderson LE, Chance MR, Bess JW, South TL, Blake PR, Sagi I, Perez-Alvarado G, Sowder RC, Hare DR. Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1. Protein Science : a Publication of the Protein Society. 1: 563-74. PMID 1304355 DOI: 10.1002/Pro.5560010502 |
0.301 |
|
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