Amy C. Sims, Ph.D.

2001 Vanderbilt University, Nashville, TN 
"Amy Sims"


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Mark R. Denison grad student 2001 Vanderbilt
 (Biochemistry of the mouse hepatitis virus replication complex.)
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Edwards CE, Yount BL, Graham RL, et al. (2020) Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection. Proceedings of the National Academy of Sciences of the United States of America
Sheahan TP, Sims AC, Zhou S, et al. (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine
Sheahan TP, Sims AC, Leist SR, et al. (2020) Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nature Communications. 11: 222
Mateo R, Lindesmith LC, Garg SJ, et al. (2019) Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development. The Journal of Infectious Diseases
Mitchell HD, Eisfeld AJ, Stratton KG, et al. (2019) The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections. Frontiers in Cell and Developmental Biology. 7: 200
Agostini ML, Pruijssers AJ, Chappell JD, et al. (2019) Small molecule antiviral β-D--hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of Virology
Brown AJ, Won JJ, Graham RL, et al. (2019) Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Research. 104541
Agostini ML, Andres EL, Sims AC, et al. (2018) Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Mbio. 9
Menachery VD, Schäfer A, Burnum-Johnson KE, et al. (2018) MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. Proceedings of the National Academy of Sciences of the United States of America
Menachery VD, Gralinski LE, Mitchell HD, et al. (2017) Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis. Msphere. 2
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