Sophia D. Sarafova, Ph.D.

Affiliations: 
2000 Columbia University, New York, NY 
Area:
Microbiology
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"Sophia Sarafova"

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Gerald Siu grad student 2000 Columbia
 (Molecular analysis of CD4 promoter function during T cell development.)
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Publications

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Freichel T, Heine V, Laaf D, et al. (2020) Sequence-Defined Heteromultivalent Precision Glycomacromolecules Bearing Sulfonated/Sulfated Nonglycosidic Moieties Preferentially Bind Galectin-3 and Delay Wound Healing of a Galectin-3 Positive Tumor Cell Line in an In Vitro Wound Scratch Assay. Macromolecular Bioscience. e2000163
Sarafova SD, Van Laethem F, Adoro S, et al. (2009) Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. Immunity. 31: 480-90
Adoro S, Erman B, Sarafova SD, et al. (2008) Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. Journal of Immunology (Baltimore, Md. : 1950). 181: 6975-83
Van Laethem F, Sarafova SD, Park JH, et al. (2007) Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. Immunity. 27: 735-50
Park JH, Adoro S, Lucas PJ, et al. (2007) 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunology. 8: 1049-59
Park J, Adoro S, Lucas PJ, et al. (2007) 118 Coreceptor Tuning: IL-7 Signals Transcriptionally Tailor CD8 Coreceptor Expression in CD8 T Cells to the Self-specificity of their TCR Cytokine. 39: 32-32
Erman B, Alag AS, Dahle O, et al. (2006) Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. Journal of Immunology (Baltimore, Md. : 1950). 177: 6613-25
Sarafova SD, Erman B, Yu Q, et al. (2005) Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity. 23: 75-87
Allen RD, Kim HK, Sarafova SD, et al. (2001) Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. Molecular and Cellular Biology. 21: 3071-82
Sarafova S, Siu G. (2000) Precise arrangement of factor-binding sites is required for murine CD4 promoter function. Nucleic Acids Research. 28: 2664-71
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