Thamotharampillai Dileepan, Ph.D.

Affiliations: 
2006 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Veterinary Science, Cell Biology, Microbiology
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"Thamotharampillai Dileepan"

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Samuel K. Maheswaran grad student 2006 UMN
 (Defining the molecular basis of species specific susceptibility to RTX toxins from Mannheimia haemolytica and Aggregatibacter (Actinobacillus) actinomycetemcomitans.)
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Publications

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Malhotra D, Linehan JL, Dileepan T, et al. (2016) Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nature Immunology
Dileepan T, Smith ED, Knowland D, et al. (2015) Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. The Journal of Clinical Investigation
Linehan JL, Dileepan T, Kashem SW, et al. (2015) Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 12782-7
Dileepan T, Kim HO, Cleary PP, et al. (2015) In Situ Peptide-MHC-II Tetramer Staining of Antigen-Specific CD4+ T Cells in Tissues. Plos One. 10: e0128862
Nelson RW, Beisang D, Tubo NJ, et al. (2015) T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity. 42: 95-107
Dileepan T, Linehan JL, Moon JJ, et al. (2011) Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. Plos Pathogens. 7: e1002252
Wang B, Dileepan T, Briscoe S, et al. (2010) Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 5937-42
Pepper M, Linehan JL, Pagán AJ, et al. (2010) Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nature Immunology. 11: 83-9
Dileepan T, Kachlany SC, Balashova NV, et al. (2007) Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin. Infection and Immunity. 75: 4851-6
Dileepan T, Kannan MS, Walcheck B, et al. (2007) Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility. Fems Microbiology Letters. 274: 67-72
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