Shaun R. Brinsmade, Ph.D.

Affiliations: 
2007 University of Wisconsin, Madison, Madison, WI 
Area:
Microbiology Biology, Biochemistry, Genetics
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"Shaun Brinsmade"

Parents

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Jorge C. Escalante-Semerena grad student 2007 UW Madison
 (Genetics and biochemistry of class II phosphotransacetylases: Enzymes and sensors of nutrition, energy and redox state of prokaryotic cells.)
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Publications

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Waters NR, Samuels DJ, Behera RK, et al. (2016) A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus. Molecular Microbiology
Belitsky BR, Brinsmade SR, Sonenshein AL. (2015) Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB. Plos Genetics. 11: e1005600
Brinsmade SR, Alexander EL, Livny J, et al. (2014) Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. Proceedings of the National Academy of Sciences of the United States of America. 111: 8227-32
Kriel A, Brinsmade SR, Tse JL, et al. (2014) GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes Journal of Bacteriology. 196: 189-201
Brinsmade SR, Sonenshein AL. (2011) Dissecting complex metabolic Integration provides direct genetic evidence for codY activation by guanine nucleotides Journal of Bacteriology. 193: 5637-5648
Lima BP, Antelmann H, Gronau K, et al. (2011) Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter. Molecular Microbiology. 81: 1190-204
Brinsmade SR, Kleijn RJ, Sauer U, et al. (2010) Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools Journal of Bacteriology. 192: 6357-6368
Brinsmade SR, Escalante-Semerena JC. (2007) In vivo and in vitro analyses of single-amino acid variants of the Salmonella enterica phosphotransacetylase enzyme provide insights into the function of its N-terminal domain. The Journal of Biological Chemistry. 282: 12629-40
Kim YR, Brinsmade SR, Yang Z, et al. (2006) Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice. Infection and Immunity. 74: 2498-502
Brinsmade SR, Paldon T, Escalante-Semerena JC. (2005) Minimal functions and physiological conditions required for growth of salmonella enterica on ethanolamine in the absence of the metabolosome. Journal of Bacteriology. 187: 8039-46
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