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John J. Mekalanos

Microbiology and Immunobiology Harvard University, Cambridge, MA, United States 
biochemical and genetic analysis of bacterial virulence factors
"John Joseph Mekalanos"


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R. John Collier grad student 1978 UCLA (Chemistry Tree)
 (Genetic and biochemical studies of cholera toxin.)


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Karen M. Ottemann grad student
Nicholas M. Judson grad student 2002 Harvard
Elizabeth A. Shakhnovich grad student 2007 Harvard
Vincent C. Tam grad student 2008 Harvard
Douglas E. Cameron grad student 2009 Harvard
Brian T. Ho grad student 2014 Harvard
Victor J. DiRita post-doc Harvard
Deborah T. Hung post-doc
Eric J. Rubin post-doc Harvard
James M. Slauch post-doc
Russell E. Vance post-doc Harvard Medical School (ID Tree)
Fabian Rivera-Chávez post-doc 2016- Harvard Medical School (Evolution Tree)
Olga Danilchanka post-doc 2012-2015
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Cartee RT, Thanawastien A, Griffin Iv TJ, et al. (2020) A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. Plos Neglected Tropical Diseases. 14: e0007912
Liang X, Kamal F, Pei TT, et al. (2019) An onboard checking mechanism ensures effector delivery of the type VI secretion system in . Proceedings of the National Academy of Sciences of the United States of America
Rivera-Chávez F, Mekalanos JJ. (2019) Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 572: 244-248
Griffin TJ, Thanawastien A, Cartee RT, et al. (2019) In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. Human Vaccines & Immunotherapeutics
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, et al. (2019) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature
Toska J, Ho BT, Mekalanos JJ. (2018) Exopolysaccharide protects from exogenous attacks by the type 6 secretion system. Proceedings of the National Academy of Sciences of the United States of America
Hubbard TP, Billings G, Dörr T, et al. (2018) A live vaccine rapidly protects against cholera in an infant rabbit model. Science Translational Medicine. 10
Fu Y, Ho BT, Mekalanos JJ. (2018) Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host & Microbe
Ho BT, Fu Y, Dong TG, et al. (2017) Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proceedings of the National Academy of Sciences of the United States of America
Hoque MM, Naser IB, Bari SM, et al. (2016) Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Scientific Reports. 6: 37956
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