Jonathan L. Linehan, Ph.D.

Affiliations: 
2012 Microbiology, Immunology and Cancer Biology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Immunology
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"Jonathan Linehan"

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Marc K. Jenkins grad student 2012 UMN
 (The Generation and Maintenance of T Helper 17 Cells in Response to Bacterial Infection.)
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Publications

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Kotov JA, Kotov DI, Linehan JL, et al. (2019) BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. The Journal of Experimental Medicine
Kalekar LA, Schmiel SE, Nandiwada SL, et al. (2016) CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nature Immunology
Malhotra D, Linehan JL, Dileepan T, et al. (2016) Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nature Immunology
Linehan JL, Dileepan T, Kashem SW, et al. (2015) Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 12782-7
Yang Y, Torchinsky MB, Gobert M, et al. (2014) Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 510: 152-6
Pauken KE, Linehan JL, Spanier JA, et al. (2013) Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 4913-7
Tubo NJ, Pagán AJ, Taylor JJ, et al. (2013) Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell. 153: 785-96
Dileepan T, Linehan JL, Moon JJ, et al. (2011) Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. Plos Pathogens. 7: e1002252
Pepper M, Linehan JL, Pagán AJ, et al. (2010) Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nature Immunology. 11: 83-9
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