Quin H. Christensen, Ph.D.
|2014-2015||Biology||Joule Unlimited Technologies, Inc.|
|2019-2021||Regulatory Affairs||Orchard Therapeutics|
|2021-||Chemistry Manufacturing and Controls||Oyster Point Pharma, Inc.|
Area:Regulatory Affairs, Gene Therapy, Metabolism, Enzymology, Lipoic Acid
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|Dong SH, Frane ND, Christensen QH, et al. (2017) Molecular basis for the substrate specificity of quorum signal synthases. Proceedings of the National Academy of Sciences of the United States of America|
|Christensen QH, Brecht RM, Dudekula D, et al. (2014) Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. Plos One. 9: e112464|
|Christensen QH, Grove TL, Booker SJ, et al. (2013) A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases. Proceedings of the National Academy of Sciences of the United States of America. 110: 13815-20|
|Bi H, Christensen QH, Feng Y, et al. (2012) The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities. Molecular Microbiology. 83: 840-55|
|Lindemann A, Pessi G, Schaefer AL, et al. (2011) Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proceedings of the National Academy of Sciences of the United States of America. 108: 16765-70|
|Christensen QH, Hagar JA, O'Riordan MX, et al. (2011) A complex lipoate utilization pathway in Listeria monocytogenes. The Journal of Biological Chemistry. 286: 31447-56|
|Christensen QH, Martin N, Mansilla MC, et al. (2011) A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis. Molecular Microbiology. 80: 350-63|
|Martin N, Christensen QH, Mansilla MC, et al. (2011) A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis. Molecular Microbiology. 80: 335-49|
|Christensen QH, Cronan JE. (2010) Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases. Biochemistry. 49: 10024-36|
|Christensen QH, Cronan JE. (2009) The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases. The Journal of Biological Chemistry. 284: 21317-26|