Gang Xia, Ph.D.

2010 Chemistry University of Alabama, Birmingham, Birmingham, AL, United States 
Biochemistry, Physical Chemistry
"Gang Xia"


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Donald D. Muccio grad student 2010 UAB
 (Structural studies of the ligand binding domain of the human retinoid X receptor bound to retinoids and the coactivator peptide GRIP-1.)
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Atigadda VR, Xia G, Deshpande A, et al. (2015) Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. Journal of Medicinal Chemistry. 58: 7763-74
Atigadda VR, Xia G, Desphande A, et al. (2014) Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. Journal of Medicinal Chemistry. 57: 5370-80
Desphande A, Xia G, Boerma LJ, et al. (2014) Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorganic & Medicinal Chemistry. 22: 178-85
Boerma LJ, Xia G, Qui C, et al. (2014) Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain. The Journal of Biological Chemistry. 289: 814-26
Xia G, Boerma LJ, Cox BD, et al. (2011) Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid. Biochemistry. 50: 93-105
Grubbs CJ, Lubet RA, Atigadda VR, et al. (2006) Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis. 27: 1232-9
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