Harvey Rubin

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Molecular Biology, Microbiology Biology
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"Harvey Rubin"

Children

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David H. Avarbock grad student 2000 Penn
Andrew B. Avarbock grad student 2005 Penn
Michael H. Buckstein grad student 2006 Penn
Jamaine S. Davis grad student 2007 Penn
Marcin Imielinski grad student 2007 Penn
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Publications

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Dutta NK, Klinkenberg LG, Vazquez MJ, et al. (2019) Inhibiting the stringent response blocks entry into quiescence and reduces persistence. Science Advances. 5: eaav2104
Harbut MB, Liu R, Yang B, et al. (2018) Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase with antimycobacterial activity. Angewandte Chemie (International Ed. in English)
Tantry SJ, Markad SD, Shinde V, et al. (2017) Discovery of Imidazo[1,2-a]pyridine ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis. Journal of Medicinal Chemistry
Chuang YM, Dutta NK, Hung CF, et al. (2016) The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo. Antimicrobial Agents and Chemotherapy
Tantry SJ, Shinde V, Balakrishnan G, et al. (2016) Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway Medchemcomm. 7: 1022-1032
Chuang YM, Bandyopadhyay N, Rifat D, et al. (2015) Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis. Mbio. 6: e02428
Rubin H, Selwood T, Yano T, et al. (2015) Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents. Bioorganic & Medicinal Chemistry Letters. 25: 378-83
Schurig-Briccio LA, Yano T, Rubin H, et al. (2014) Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines. Biochimica Et Biophysica Acta. 1837: 954-63
Yano T, Rahimian M, Aneja KK, et al. (2014) Mycobacterium tuberculosis type II NADH-menaquinone oxidoreductase catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sites. Biochemistry. 53: 1179-90
Thayil SM, Morrison N, Schechter N, et al. (2011) The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence. Plos One. 6: e28076
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