Mark A. Gregory, Ph.D.

Affiliations: 
2003 Vanderbilt University, Nashville, TN 
Area:
Cell Biology, Molecular Biology
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"Mark Gregory"

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Stephen R. Hann grad student 2003 Vanderbilt
 (Post-translational regulation of the Myc oncoprotein.)
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Publications

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Alvarez-Calderon F, Gregory MA, Pham-Danis C, et al. (2015) Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1360-72
Gardner LA, Klawitter J, Gregory MA, et al. (2014) Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia. American Journal of Hematology. 89: 896-903
Spreafico A, Tentler JJ, Pitts TM, et al. (2013) Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4149-62
Zhang Q, Spears E, Boone DN, et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proceedings of the National Academy of Sciences of the United States of America. 110: 978-83
Alvarez-Calderon F, Gregory MA, DeGregori J. (2013) Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunologic Research. 55: 100-15
Nifoussi SK, Vrana JA, Domina AM, et al. (2012) Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer. Plos One. 7: e47060
Gregory MA, Phang TL, Neviani P, et al. (2010) Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell. 18: 74-87
Gregory MA, Qi Y, Hann SR. (2005) The ARF tumor suppressor: keeping Myc on a leash. Cell Cycle (Georgetown, Tex.). 4: 249-52
Qi Y, Gregory MA, Li Z, et al. (2004) p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature. 431: 712-7
Domina AM, Vrana JA, Gregory MA, et al. (2004) MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene. 23: 5301-15
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