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Peter J. Roach

Affiliations: 
Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Molecular Biology, Microbiology Biology
Website:
https://medicine.iu.edu/faculty/15102/roach-peter/
Google:
"Peter John Roach"

Parents

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Daniel E. Atkinson post-doc (Chemistry Tree)
Joseph Larner post-doc
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Publications

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Skurat AV, Segvich DM, Contreras CJ, et al. (2024) Impaired malin expression and interaction with partner proteins in Lafora disease. The Journal of Biological Chemistry. 300: 107271
Ullman JC, Mellem KT, Xi Y, et al. (2024) Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. Science Translational Medicine. 16: eadf1691
Fastman NM, Liu Y, Ramanan V, et al. (2022) The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell Reports. 40: 111041
Sun RC, Young LEA, Bruntz RC, et al. (2021) Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Cell Metabolism
Chown EE, Wang P, Zhao X, et al. (2020) GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. Annals of Clinical and Translational Neurology
Tang B, Frasinyuk MS, Chikwana VM, et al. (2020) Discovery and development of small-molecule inhibitors of glycogen synthase. Journal of Medicinal Chemistry
Young LEA, Brizzee CO, Macedo JKA, et al. (2020) Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry. Carbohydrate Polymers. 230: 115651
Visuttijai K, Hedberg-Oldfors C, Thomsen C, et al. (2020) Glycogenin is Dispensable for Glycogen Synthesis in Human Muscle, and Glycogenin Deficiency Causes Polyglucosan Storage. The Journal of Clinical Endocrinology and Metabolism. 105: 557-566
Brewer MK, Uittenbogaard A, Austin GL, et al. (2019) Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion. Cell Metabolism
Burlet-Godinot S, Petit J-, Roach PJ, et al. (2019) New insights into the “Glycogenetic” hypothesis of sleep: brain glycogen availability affects REM-related theta rhythm providing a possible link with emotional memory mechanisms Sleep Medicine. 64
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