David M. Bedwell

University of Alabama, Birmingham, Birmingham, AL, United States 
Microbiology Biology
"David Bedwell"


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Barclay L. Browne grad student 2000 UAB
Kim M. Keeling grad student 2000 UAB
Julie Y. Koh grad student 2001 UAB
David P. Aiello grad student 2003 UAB
Joe Salas-Marco grad student 2004 UAB
Hua Fan-Minogue grad student 2007 UAB
Adam K. Kallmeyer grad student 2007 UAB
Sara E. Conard grad student 2013 UAB
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Xue X, Mutyam V, Thakerar A, et al. (2017) Identification of the Amino Acids Inserted During Suppression of CFTR Nonsense Mutations and Determination of Their Functional Consequences. Human Molecular Genetics
Roy B, Friesen WJ, Tomizawa Y, et al. (2016) Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. Proceedings of the National Academy of Sciences of the United States of America
Mutyam V, Du M, Xue X, et al. (2016) Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations. American Journal of Respiratory and Critical Care Medicine
Kelly SP, Bedwell DM. (2015) Both the autophagy and proteasomal pathways facilitate the Ubp3p-dependent depletion of a subset of translation and RNA turnover factors during nitrogen starvation in Saccharomyces cerevisiae. Rna (New York, N.Y.). 21: 898-910
Keeling KM, Xue X, Gunn G, et al. (2014) Therapeutics based on stop codon readthrough. Annual Review of Genomics and Human Genetics. 15: 371-94
Tuggle KL, Birket SE, Cui X, et al. (2014) Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. Plos One. 9: e91253
Gunn G, Dai Y, Du M, et al. (2014) Long-term nonsense suppression therapy moderates MPS I-H disease progression. Molecular Genetics and Metabolism. 111: 374-81
Zhang S, Ranganath NK, Skinner D, et al. (2014) Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 351-2
Xue X, Mutyam V, Tang L, et al. (2014) Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. American Journal of Respiratory Cell and Molecular Biology. 50: 805-16
Aeffner F, Abdulrahman B, Hickman-Davis JM, et al. (2013) Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity. The Journal of Infectious Diseases. 208: 780-9
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