James E. Casanova

University of Virginia, Charlottesville, VA 
Cell Biology, Microbiology Biology
"James Casanova"


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Ellen J. Cuthbert grad student 2007 UVA
Kim T. Ly grad student 2009 UVA
Radim Moravec grad student 2012 UVA
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Billings EA, Lee CS, Owen KA, et al. (2016) The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Science Signaling. 9: ra14
Owen KA, Anderson CJ, Casanova JE. (2015) Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages. Mbio. 7
Owen KA, Casanova JE. (2015) Salmonella Manipulates Autophagy to "Serve and Protect". Cell Host & Microbe. 18: 517-9
Owen KA, Meyer CB, Bouton AH, et al. (2014) Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. Plos Pathogens. 10: e1004159
D'Souza RS, Semus R, Billings EA, et al. (2014) Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes Current Biology. 24: 1187-1198
Casanova JE, Hsu VW, Jackson CL, et al. (2013) Meeting report - Arf and Rab family G proteins. Journal of Cell Science. 126: 5313-6
Myers KR, Wang G, Sheng Y, et al. (2012) Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11716-26
Moravec R, Conger KK, D'Souza R, et al. (2012) BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). The Journal of Biological Chemistry. 287: 31138-47
Owen KA, Abshire MY, Tilghman RW, et al. (2011) FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. Plos One. 6: e23123
Das S, Owen KA, Ly KT, et al. (2011) Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proceedings of the National Academy of Sciences of the United States of America. 108: 2136-41
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