Elizabeth A. Leadbetter, Ph.D.

Affiliations: 
2002 Boston University, Boston, MA, United States 
Area:
Immunology
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"Elizabeth Leadbetter"

Parents

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Ann Marshak-Rothstein grad student 2002 Boston University
 (Chromatin/IgG immune complexes activate autoreactive B cells by dual engagement of B cell receptors and Toll -like receptors.)
Michael B. Brenner post-doc (Chemistry Tree)
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Publications

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Vomhof-DeKrey EE, Yates J, Hägglöf T, et al. (2015) Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 12474-9
Lynch L, Michelet X, Zhang S, et al. (2015) Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nature Immunology. 16: 85-95
Blackman MA, Yates JL, Spencer CM, et al. (2014) The Yin and Yang of inflammation. Current Molecular Medicine. 14: 1238-43
Vomhof-DeKrey EE, Yates J, Leadbetter EA. (2014) Invariant NKT cells provide innate and adaptive help for B cells. Current Opinion in Immunology. 28: 12-7
King IL, Amiel E, Tighe M, et al. (2013) The mechanism of splenic invariant NKT cell activation dictates localization in vivo. Journal of Immunology (Baltimore, Md. : 1950). 191: 572-82
Detre C, Keszei M, Garrido-Mesa N, et al. (2012) SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood. 120: 122-9
King IL, Fortier A, Tighe M, et al. (2012) Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nature Immunology. 13: 44-50
Brigl M, Tatituri RV, Watts GF, et al. (2011) Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. The Journal of Experimental Medicine. 208: 1163-77
Veerapen N, Leadbetter EA, Brenner MB, et al. (2010) Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies. Bioconjugate Chemistry. 21: 741-7
Leadbetter EA, Brigl M, Illarionov P, et al. (2008) NK T cells provide lipid antigen-specific cognate help for B cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 8339-44
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