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Anna M. Mielech, Ph.D.

Affiliations: 
2014 Microbiology and Immunology Loyola University Chicago, Chicago, IL, United States 
Area:
Virology Biology, Microbiology Biology, Immunology
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"Anna Mielech"
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Thomas M. Gallagher grad student 2014 Loyola University Chicago
 (Multifunctional coronavirus papain-like proteases as targets for antiviral therapeutics and vaccines.)

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Publications

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Deng X, Chen Y, Mielech AM, et al. (2020) Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus. Journal of Virology
Niemeyer D, Mösbauer K, Klein EM, et al. (2018) The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species. Plos Pathogens. 14: e1007296
Deng X, Hackbart M, Mettelman RC, et al. (2017) Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages. Proceedings of the National Academy of Sciences of the United States of America
Chen Y, Savinov SN, Mielech AM, et al. (2015) X-ray Structural and Functional Studies of the Three Tandemly-Linked Domains of Nsp3 from Murine Hepatitis Virus Reveal Conserved Functions. The Journal of Biological Chemistry
Mielech AM, Deng X, Chen Y, et al. (2015) Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis. Journal of Virology. 89: 4907-17
Báez-Santos YM, Mielech AM, Deng X, et al. (2014) Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. Journal of Virology. 88: 12511-27
Deng X, Agnihothram S, Mielech AM, et al. (2014) A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. Journal of Virology. 88: 11825-33
Báez-Santos YM, Barraza SJ, Wilson MW, et al. (2014) X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. Journal of Medicinal Chemistry. 57: 2393-412
Mielech AM, Chen Y, Mesecar AD, et al. (2014) Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Research. 194: 184-90
Mielech AM, Kilianski A, Baez-Santos YM, et al. (2014) MERS-CoV papain-like protease has deISGylating and deubiquitinating activities. Virology. 450: 64-70
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