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Ross E. Zirkle, Ph.D.

Affiliations: 
2003 North Carolina State University, Raleigh, NC 
Area:
Microbiology Biology
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"Ross Zirkle"
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James M. Ligon grad student 2003 NCSU
 (The genetics of Sorangium cellulosum So ce26 and the biosynthesis of the antifungal polyketide soraphen A.)

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Publications

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Trefzer A, Jungmann V, Molnár I, et al. (2007) Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. Applied and Environmental Microbiology. 73: 4317-25
Molnár I, Hill DS, Zirkle R, et al. (2005) Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. Applied and Environmental Microbiology. 71: 6977-85
Jungmann V, Molnár I, Hammer PE, et al. (2005) Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. Applied and Environmental Microbiology. 71: 6968-76
Zirkle R, Ligon JM, Molnár I. (2004) Cloning, sequence analysis and disruption of the mglA gene involved in swarming motility of Sorangium cellulosum So ce26, a producer of the antifungal polyketide antibiotic soraphen A. Journal of Bioscience and Bioengineering. 97: 267-74
Zirkle R, Black TA, Gorlach J, et al. (2004) Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus. Dna Sequence : the Journal of Dna Sequencing and Mapping. 15: 123-34
Zirkle R, Ligon JM, Molnár I. (2004) Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans. Microbiology (Reading, England). 150: 2761-74
Ligon J, Hill S, Beck J, et al. (2002) Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26. Gene. 285: 257-67
Molnár I, Schupp T, Ono M, et al. (2000) The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. Chemistry & Biology. 7: 97-109
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