Kim M. Keeling, Ph.D.

Affiliations: 
2000 University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Genetics, Molecular Biology
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"Kim Keeling"

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David M. Bedwell grad student 2000 UAB
 (Suppression of premature stop mutations using aminoglycosides.)
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Publications

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Xue X, Mutyam V, Thakerar A, et al. (2017) Identification of the Amino Acids Inserted During Suppression of CFTR Nonsense Mutations and Determination of Their Functional Consequences. Human Molecular Genetics
Roy B, Friesen WJ, Tomizawa Y, et al. (2016) Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. Proceedings of the National Academy of Sciences of the United States of America
Mutyam V, Du M, Xue X, et al. (2016) Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations. American Journal of Respiratory and Critical Care Medicine
Keeling KM, Xue X, Gunn G, et al. (2014) Therapeutics based on stop codon readthrough. Annual Review of Genomics and Human Genetics. 15: 371-94
Gunn G, Dai Y, Du M, et al. (2014) Long-term nonsense suppression therapy moderates MPS I-H disease progression. Molecular Genetics and Metabolism. 111: 374-81
Keeling KM, Wang D, Dai Y, et al. (2013) Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. Plos One. 8: e60478
Keeling KM, Wang D, Conard SE, et al. (2012) Suppression of premature termination codons as a therapeutic approach. Critical Reviews in Biochemistry and Molecular Biology. 47: 444-63
Wang D, Belakhov V, Kandasamy J, et al. (2012) The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse. Molecular Genetics and Metabolism. 105: 116-25
Keeling KM, Bedwell DM. (2011) Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases. Wiley Interdisciplinary Reviews. Rna. 2: 837-52
Lazrak A, Jurkuvenaite A, Chen L, et al. (2011) Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 301: L557-67
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