Kim M. Keeling, Ph.D.

Affiliations: 
2000 University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Genetics, Molecular Biology
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"Kim Keeling"

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David M. Bedwell grad student 2000 UAB
 (Suppression of premature stop mutations using aminoglycosides.)
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Publications

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Mangkalaphiban K, Fu L, Du M, et al. (2024) Extended stop codon context predicts nonsense codon readthrough efficiency in human cells. Nature Communications. 15: 2486
Siddiqui A, Saxena A, Echols J, et al. (2023) RNA binding proteins PTBP1 and HNRNPL regulate mRNA decay. Heliyon. 9: e22281
Staedtke V, Anstett K, Bedwell D, et al. (2023) Gene-targeted therapy for neurofibromatosis and schwannomatosis: The path to clinical trials. Clinical Trials (London, England). 17407745231207970
Chen J, Thrasher K, Fu L, et al. (2023) The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing super-functional protein that can be further enhanced by CFTR modulators. American Journal of Physiology. Lung Cellular and Molecular Physiology
Siddiqui A, Dundar H, Sharma J, et al. (2023) Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome). International Journal of Molecular Sciences. 24
Wang D, Xue X, Gunn G, et al. (2022) Ataluren suppresses a premature termination codon in an MPS I-H mouse. Journal of Molecular Medicine (Berlin, Germany)
Sharma J, Du M, Wong E, et al. (2021) A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nature Communications. 12: 4358
Echols J, Siddiqui A, Dai Y, et al. (2020) A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases. Disease Models & Mechanisms
Echols J, Siddiqui A, Dai Y, et al. (2020) A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases. Disease Models & Mechanisms
Sharma J, Keeling KM, Rowe SM. (2020) Pharmacological approaches for targeting cystic fibrosis nonsense mutations. European Journal of Medicinal Chemistry. 200: 112436
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