Edward J. Brignole, Ph.D.

2005 Johns Hopkins University, Baltimore, MD 
Microbiology Biology, Molecular Biology, Biochemistry
"Edward Brignole"


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Wade Gibson grad student 2005 Johns Hopkins
 (Expression and purification of the human cytomegalovirus protease precursor: Initial characterizations of its physical and enzymatic properties.)
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Fernandes SM, Brignole EJ, Taori K, et al. (2011) Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin). Journal of Virology. 85: 3526-34
Brignole EJ, Gibson W. (2007) Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain. Journal of Virology. 81: 4091-103
Loveland AN, Nguyen NL, Brignole EJ, et al. (2007) The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus production. Journal of Virology. 81: 620-8
Loveland AN, Chan CK, Brignole EJ, et al. (2005) Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. Journal of Virology. 79: 12961-8
McCartney SA, Brignole EJ, Kolegraff KN, et al. (2005) Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a. The Journal of Biological Chemistry. 280: 33206-12
Casaday RJ, Bailey JR, Kalb SR, et al. (2004) Assembly protein precursor (pUL80.5 homolog) of simian cytomegalovirus is phosphorylated at a glycogen synthase kinase 3 site and its downstream "priming" site: phosphorylation affects interactions of protein with itself and with major capsid protein. Journal of Virology. 78: 13501-11
Chan CK, Brignole EJ, Gibson W. (2002) Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. Journal of Virology. 76: 8667-74
Ahn JH, Brignole EJ, Hayward GS. (1998) Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML Molecular and Cellular Biology. 18: 4899-4913
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