George T. Lountos, Ph.D.

Affiliations: 
2005 Georgia Institute of Technology, Atlanta, GA 
Area:
Biochemistry
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"George Lountos"

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Allen M. Orville grad student 2005 Georgia Tech
 (Structural and mechanistic insights from high resolution crystal structures of the toluene -4 -monooxygenase catalytic effector protein, NAD(P)H oxidase and choline oxidase.)
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Publications

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Hewitt WM, Lountos GT, Zlotkowski K, et al. (2016) Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angewandte Chemie (International Ed. in English)
Zhao BM, Keasey SL, Tropea JE, et al. (2015) Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. Plos One. 10: e0134984
Lountos GT, Austin BP, Tropea JE, et al. (2015) Structure of human dual-specificity phosphatase 7, a potential cancer drug target. Acta Crystallographica. Section F, Structural Biology Communications. 71: 650-6
Needle D, Lountos GT, Waugh DS. (2015) Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity. Acta Crystallographica. Section D, Biological Crystallography. 71: 1102-11
Lountos GT, Cherry S, Tropea JE, et al. (2015) Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallographica. Section F, Structural Biology Communications. 71: 199-205
Hogan M, Bahta M, Cherry S, et al. (2013) Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase. Chemical Biology & Drug Design. 81: 323-33
Lountos GT, Tropea JE, Waugh DS. (2012) Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Acta Crystallographica. Section D, Biological Crystallography. 68: 201-9
Lountos GT, Jobson AG, Tropea JE, et al. (2011) Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy Journal of Structural Biology. 176: 292-301
Lountos GT, Jobson AG, Tropea JE, et al. (2011) X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket Febs Letters. 585: 3245-3249
Kim SE, Bahta M, Lountos GT, et al. (2011) Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH. Acta Crystallographica. Section D, Biological Crystallography. 67: 639-45
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