George T. Lountos, Ph.D.
Affiliations: | 2005 | Georgia Institute of Technology, Atlanta, GA |
Area:
BiochemistryGoogle:
"George Lountos"Parents
Sign in to add mentorAllen M. Orville | grad student | 2005 | Georgia Tech | |
(Structural and mechanistic insights from high resolution crystal structures of the toluene -4 -monooxygenase catalytic effector protein, NAD(P)H oxidase and choline oxidase.) |
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Publications
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Zhao XZ, Wang W, Lountos GT, et al. (2023) Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chemical Biology. 4: 334-343 |
Hoffka G, Lountos GT, Needle D, et al. (2023) Self-inhibited state of Venezuelan equine encephalitis virus (VEEV) nsP2 cysteine protease: a crystallographic and molecular dynamics analysis. Journal of Molecular Biology. 168012 |
Gustchina A, Li M, Andrianova AG, et al. (2022) Unique Structural Fold of LonBA Protease from a Member of a Newly Identified Subfamily of Lon Proteases. International Journal of Molecular Sciences. 23 |
Zhao XZ, Wang W, Lountos GT, et al. (2022) Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Frontiers in Chemistry. 10: 910953 |
Zhao XZ, Kiselev E, Lountos GT, et al. (2021) Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites. Chemical Science. 12: 3876-3884 |
Botos I, Lountos GT, Wu W, et al. (2019) Cryo-EM structure of substrate-free Lon protease provides insights into the dynamics of Lon machinery. Current Research in Structural Biology. 1: 13-20 |
Gibbs ME, Lountos GT, Gumpena R, et al. (2019) Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague. Acta Crystallographica. Section F, Structural Biology Communications. 75: 608-615 |
Lountos GT, Zhao XZ, Kiselev E, et al. (2019) Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Research |
Hogan M, Bahta M, Tsuji K, et al. (2019) Targeting protein-protein interactions of tyrosine phosphatases with microarrayed fragment libraries displayed on phosphopeptide substrate scaffolds. Acs Combinatorial Science |
Lountos GT, Gibbs ME, Gumpena R, et al. (2019) Crystal structure of the UDP-glucose pyrophosphorylase from Yersinia pestis, a drug target for new anti-plague agents Acta Crystallographica Section a Foundations and Advances. 75: a305-a305 |