David Sinclair

Harvard University, Cambridge, MA, United States 
Genetics, Molecular Biology, Microbiology Biology
"David Sinclair"


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Kevin J. Bitterman grad student 2004 Harvard
Oliver Medvedik grad student 2006 Harvard
Magda M. Latorre-Esteves grad student 2007 Harvard
Dudley W. Lamming grad student 2008 Harvard
Sean M. Armour grad student 2010 Harvard
Juan J. Carmona grad student 2010 Harvard
Basil P. Hubbard grad student 2011 Harvard
Jaime M. Ross post-doc 2015- Harvard Medical School (Neurotree)
Mohammad Parvez Alam post-doc 2018- Harvard Medical School (Chemistry Tree)
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Wahl D, Solon-Biet SM, Wang QP, et al. (2018) Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports. 25: 2234-2243.e6
Mitchell SJ, Bernier M, Aon MA, et al. (2018) Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metabolism. 27: 667-676.e4
Li J, Bonkowski MS, Moniot S, et al. (2017) A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.). 355: 1312-1317
Fang EF, Kassahun H, Croteau DL, et al. (2016) NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. 24: 566-581
Van Meter M, Simon M, Tombline G, et al. (2016) JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports
Dai H, Ellis JL, Sinclair DA, et al. (2016) Synthesis and Assay of SIRT1-Activating Compounds. Methods in Enzymology. 574: 213-44
Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, et al. (2016) Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism. 23: 1093-1112
Mohamad M, Mitchell SJ, Wu LE, et al. (2016) Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell
Anderson EN, Corkins ME, Li JC, et al. (2016) C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development
Schultz MB, Sinclair DA. (2016) When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development (Cambridge, England). 143: 3-14
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