Geoffrey H. Holm, Ph.D.

Affiliations: 
2004 Harvard University, Cambridge, MA, United States 
Area:
Microbiology Biology, Immunology
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"Geoffrey Holm"

Parents

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Dana Gabuzda grad student 2004 Harvard
 (Mechanisms of bystander T cell apoptosis in HIV-1 infection.)
Terence S. Dermody post-doc 2005-2008 Vanderbilt
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Publications

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Stuart JD, Holm GH, Boehme KW. (2018) Differential delivery of genomic dsRNA causes reovirus strain-specific differences in IRF3 activation. Journal of Virology
Danthi P, Holm GH, Stehle T, et al. (2013) Reovirus receptors, cell entry, and proapoptotic signaling. Advances in Experimental Medicine and Biology. 790: 42-71
Knowlton JJ, Dermody TS, Holm GH. (2012) Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-κB-dependent expression of Noxa. Journal of Virology. 86: 1650-60
Danthi P, Pruijssers AJ, Berger AK, et al. (2010) Bid regulates the pathogenesis of neurotropic reovirus. Plos Pathogens. 6: e1000980
Holm GH, Pruijssers AJ, Li L, et al. (2010) Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. Journal of Virology. 84: 6900-8
Zurney J, Kobayashi T, Holm GH, et al. (2009) Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. Journal of Virology. 83: 2178-87
Danthi P, Kobayashi T, Holm GH, et al. (2008) Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. Journal of Virology. 82: 161-72
Kobayashi T, Antar AA, Boehme KW, et al. (2007) A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host & Microbe. 1: 147-57
Holm GH, Zurney J, Tumilasci V, et al. (2007) Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. The Journal of Biological Chemistry. 282: 21953-61
Guglielmi KM, Kirchner E, Holm GH, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. The Journal of Biological Chemistry. 282: 17930-40
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