Kevin J. Bitterman, Ph.D.
Affiliations: | 2004 | Harvard University, Cambridge, MA, United States |
Area:
Molecular Biology, Cell Biology, GeneticsGoogle:
"Kevin Bitterman"Parents
Sign in to add mentor| David Sinclair | grad student | 2004 | Harvard | |
| (Regulation of the Sir2 family of deacetylases.) | ||||
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Publications
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| Anderson RM, Bitterman KJ, Wood JG, et al. (2013) Manipulation of a nuclear NAD + salvage pathway delays aging without altering steady-state NAD + levels. Journal of Biological Chemistry. 288: 24160-24160 |
| Cohen HY, Miller C, Bitterman KJ, et al. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science. 305: 390-392 |
| Cohen HY, Lavu S, Bitterman KJ, et al. (2004) Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular Cell. 13: 627-38 |
| Bitterman KJ, Medvedik O, Sinclair DA. (2003) Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiology and Molecular Biology Reviews : Mmbr. 67: 376-99, table of con |
| Howitz KT, Bitterman KJ, Cohen HY, et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425: 191-6 |
| Anderson RM, Bitterman KJ, Wood JG, et al. (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423: 181-5 |
| Bitterman KJ, Anderson RM, Cohen HY, et al. (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. The Journal of Biological Chemistry. 277: 45099-107 |
| Anderson RM, Bitterman KJ, Wood JG, et al. (2002) Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. The Journal of Biological Chemistry. 277: 18881-90 |