Basil P. Hubbard, Ph.D.
Affiliations: | 2011 | Harvard University, Cambridge, MA, United States |
Area:
Biochemistry, Molecular Biology, GeneticsGoogle:
"Basil Hubbard"Parents
Sign in to add mentor| David Sinclair | grad student | 2011 | Harvard | |
| (Mechanisms of Mammalian Sirtuin Regulation in Health and Disease.) | ||||
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Publications
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| Salla M, Pandya V, Bhullar KS, et al. (2020) Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs. Molecules (Basel, Switzerland). 25 |
| Salla M, Aguayo-Ortiz R, Gaddafi Ibrahim D, et al. (2018) Identification and Characterization of Novel Receptor Interacting Serine/threonine-Protein Kinase 2 (RIPK2) Inhibitors Using Structural Similarity Analysis. The Journal of Pharmacology and Experimental Therapeutics |
| Li J, Bonkowski MS, Moniot S, et al. (2017) A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.). 355: 1312-1317 |
| Van Meter M, Simon M, Tombline G, et al. (2016) JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports |
| Dai H, Ellis JL, Sinclair DA, et al. (2016) Synthesis and Assay of SIRT1-Activating Compounds. Methods in Enzymology. 574: 213-44 |
| Hubbard BP, Badran AH, Zuris JA, et al. (2015) Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nature Methods. 12: 939-42 |
| Bhullar KS, Hubbard BP. (2015) Lifespan and healthspan extension by resveratrol. Biochimica Et Biophysica Acta. 1852: 1209-18 |
| Hubbard BP, Sinclair DA. (2014) Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends in Pharmacological Sciences. 35: 146-54 |
| Gomes AP, Price NL, Ling AJ, et al. (2013) Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 155: 1624-38 |
| Hubbard BP, Sinclair DA. (2013) Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods in Molecular Biology (Clifton, N.J.). 1077: 167-77 |