Caroline L. Ng, Ph.D.

Affiliations: 
2011 Microbiology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Microbiology Biology, Molecular Biology
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"Caroline Ng"

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Domenico Tortorella grad student 2011 Mount Sinai School of Medicine
 (Molecular analysis of ER-to-cytosol polypeptide dislocation.)
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Publications

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Rosenthal MR, Ng CL. (2021) A Proteasome Mutation Sensitizes Cam3.II K13 Parasites to DHA and OZ439. Acs Infectious Diseases
Rosenthal MR, Ng CL. (2020) artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response. Acs Infectious Diseases
Stokes BH, Yoo E, Murithi JM, et al. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. Plos Pathogens. 15: e1007722
White J, Dhingra S, Deng X, et al. (2018) Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265. Acs Infectious Diseases
Yoo E, Stokes BH, de Jong H, et al. (2018) Defining the determinants of specificity of Plasmodium proteasome inhibitors. Journal of the American Chemical Society
Llanos-Cuentas A, Casapia M, Chuquiyauri R, et al. (2018) Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study. The Lancet. Infectious Diseases
Vanaerschot M, Lucantoni L, Li T, et al. (2017) Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature Microbiology
Ng CL, Fidock DA, Bogyo M. (2017) Protein Degradation Systems as Antimalarial Therapeutic Targets. Trends in Parasitology
Sonoiki E, Ng CL, Lee MC, et al. (2017) A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nature Communications. 8: 14574
Le Bihan A, de Kanter R, Angulo-Barturen I, et al. (2016) Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. Plos Medicine. 13: e1002138
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