Caroline L. Ng, Ph.D.

Affiliations: 
2011 Microbiology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Microbiology Biology, Molecular Biology
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"Caroline Ng"

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Domenico Tortorella grad student 2011 Mount Sinai School of Medicine
 (Molecular analysis of ER-to-cytosol polypeptide dislocation.)
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Publications

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Imhoff RD, Rosenthal MR, Ashraf K, et al. (2023) Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy. Bioorganic & Medicinal Chemistry Letters. 94: 129458
Rosenthal M, Ng C. (2023) Parasite proteostasis and artemisinin resistance. Research Square
Deni I, Stokes BH, Ward KE, et al. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology
Rosenthal MR, Ng CL. (2021) A Proteasome Mutation Sensitizes Cam3.II K13 Parasites to DHA and OZ439. Acs Infectious Diseases
Rosenthal MR, Ng CL. (2020) artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response. Acs Infectious Diseases
Stokes BH, Yoo E, Murithi JM, et al. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. Plos Pathogens. 15: e1007722
White J, Dhingra S, Deng X, et al. (2018) Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265. Acs Infectious Diseases
Yoo E, Stokes BH, de Jong H, et al. (2018) Defining the determinants of specificity of Plasmodium proteasome inhibitors. Journal of the American Chemical Society
Llanos-Cuentas A, Casapia M, Chuquiyauri R, et al. (2018) Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study. The Lancet. Infectious Diseases
Vanaerschot M, Lucantoni L, Li T, et al. (2017) Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature Microbiology
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