Robert W. Huigens, Ph.D.
Affiliations: | 2009 | North Carolina State University, Raleigh, NC |
Area:
Organic Chemistry, Microbiology BiologyGoogle:
"Robert Huigens"Parents
Sign in to add mentor| Christian Melander | grad student | 2009 | NCSU | |
| (The development of ageliferin inspired small molecules as antibiofilm and antibacterial agents against multidrug resistant bacterial pathogens.) | ||||
Children
Sign in to add trainee| Aaron T Garrison | grad student | 2013-2017 | UF Gainesville (Chemistry Tree) |
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Publications
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| Liu K, Xiao T, Yang H, et al. (2023) Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation. Rsc Medicinal Chemistry. 14: 1472-1481 |
| Xiao T, Liu K, Gao Q, et al. (2023) Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles. Acs Infectious Diseases |
| Huigens RW, Brummel BR, Tenneti S, et al. (2022) Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery. Molecules (Basel, Switzerland). 27 |
| Liu K, Brivio M, Xiao T, et al. (2022) Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Biofilms. Acs Infectious Diseases |
| Yang H, Kundra S, Chojnacki M, et al. (2021) A Modular Synthetic Route Involving -Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. Journal of Medicinal Chemistry |
| Fu T, Cai Z, Yue Z, et al. (2021) Evolution of Resistance to Phenazine Antibiotics in and Its Role During Coinfection with . Acs Infectious Diseases |
| Huigens RW. (2020) Targeting bacterial biofilms with persister-killing agents. Future Medicinal Chemistry |
| Paciaroni NG, Norwood VM, Ratnayake R, et al. (2020) Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorganic & Medicinal Chemistry. 28: 115546 |
| Valentine-King MA, Cisneros K, James MO, et al. (2020) Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas. Bmc Veterinary Research. 16: 107 |
| Norwood V, Brice-Tutt AC, Eans SO, et al. (2020) Preventing Morphine-SeekingBehavior through the Re-Engineeringof Vincamine’s Biological Activity Journal of Medicinal Chemistry |