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Brian D. Ames, Ph.D.

Affiliations: 
2004-2009 Biological Sciences - Ph.D. University of California, Irvine, Irvine, CA 
 2009-2011 Biological Chemistry and Molecular Pharmacology - Postdoc Harvard Medical School, Boston, MA, United States 
 2011-2019 Cardiovascular and Metabolic Diseases Novartis Institutes for BioMedical Research, Cambridge, MA, United States 
Area:
Biochemistry, Molecular Biology, Microbiology Biology
Website:
https://www.linkedin.com/in/brian-ames-ab53b713/
Google:
"Brian Ames, Novartis, Boston"
Bio:

Protein biochemist with 7+ years working in the pharmaceutical industry at the Novartis Institutes for BioMedical Research (NIBR) in the Analytical Biochemistry unit of Cardiovascular and Metabolic Diseases. Before joining Novartis, I earned my PhD at the University of California – Irvine (Shiou-Chuan [Sheryl] Tsai lab) and was an NIH Postdoctoral Fellow at Harvard Medical School with Christopher T. Walsh.

As a graduate student, I investigated the sequence-structure-function relationship of enzymes responsible for bacterial and fungal polyketide biosynthesis. My postdoctoral work defined novel pathways and enzyme chemistry used by fungi to produce anthranilic acid-containing indole alkaloids.

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Parents

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Shiou-Chuan Tsai grad student 2009 UC Irvine
 (Cyclization and reduction of polyketides: Structure-function studies of aromatase/cyclase and the trans-acting enoyl reductase LovC.)
Christopher  T. Walsh post-doc 2009-2011 Harvard University (medical School) (Chemistry Tree)
Jovita Marcinkeviciene research scientist 2011-2019 Novartis Institutes for BioMedical Research

Collaborators

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Yi Tang collaborator 2004-2011 UCLA (Chemistry Tree)
John C. Vederas collaborator 2008-2012 University of Alberta (Chemistry Tree)
Nancy P. Keller collaborator 2012-2014 UW Madison
BETA: Related publications

Publications

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Walsh CT, Haynes SW, Ames BD, et al. (2013) Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82
Gao X, Haynes SW, Ames BD, et al. (2012) Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30
Ames BD, Nguyen C, Bruegger J, et al. (2012) Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9
Lee MY, Ames BD, Tsai SC. (2012) Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 51: 3079-91
Walsh CT, Haynes SW, Ames BD. (2012) Aminobenzoates as building blocks for natural product assembly lines. Natural Product Reports. 29: 37-59
Ames BD, Haynes SW, Gao X, et al. (2011) Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69
Ames BD, Lee MY, Moody C, et al. (2011) Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 50: 8392-406
Zhang W, Ames BD, Walsh CT. (2011) Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis. Biochemistry. 50: 5401-3
Haynes SW, Ames BD, Gao X, et al. (2011) Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79
Gao X, Chooi YH, Ames BD, et al. (2011) Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41
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