James G. Smedley, Ph.D.
Affiliations: | 2007 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Microbiology Biology, BiochemistryGoogle:
"James Smedley"Parents
Sign in to add mentor| Bruce McClane | grad student | 2007 | University of Pittsburgh | |
| (Investigating the molecular mechanism of action of Clostridium perfringens enterotoxin using structure-function and oligomeric analyses.) | ||||
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| Chen J, Theoret JR, Shrestha A, et al. (2012) Cysteine-scanning mutagenesis supports the importance of Clostridium perfringens enterotoxin amino acids 80 to 106 for membrane insertion and pore formation. Infection and Immunity. 80: 4078-88 |
| Briggs DC, Naylor CE, Smedley JG, et al. (2011) Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. Journal of Molecular Biology. 413: 138-49 |
| Briggs DC, Smedley JG, McClane BA, et al. (2010) Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 794-7 |
| Robertson SL, Smedley JG, McClane BA. (2010) Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin. Infection and Immunity. 78: 505-17 |
| Smedley JG, Saputo J, Parker JC, et al. (2008) Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity. Infection and Immunity. 76: 3793-800 |
| Van Itallie CM, Betts L, Smedley JG, et al. (2008) Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. The Journal of Biological Chemistry. 283: 268-74 |
| Kominsky SL, Tyler B, Sosnowski J, et al. (2007) Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Research. 67: 7977-82 |
| Robertson SL, Smedley JG, Singh U, et al. (2007) Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cellular Microbiology. 9: 2734-55 |
| Litkouhi B, Kwong J, Lo CM, et al. (2007) Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia (New York, N.Y.). 9: 304-14 |
| Smedley JG, Uzal FA, McClane BA. (2007) Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin. Infection and Immunity. 75: 2381-90 |