Patrick R. Cushing, Ph.D.

Affiliations: 
2011 Biochemistry Dartmouth College, Hanover, NH, United States 
Area:
Biochemistry
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"Patrick Cushing"

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Dean R. Madden grad student 2011 Dartmouth
 (From Target Discovery to High-Throughput Sereens--Selective CAL PDZ Inhihitors as Candidate CF Therapeutics.)
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Publications

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Zhao Y, Cushing PR, Smithson DC, et al. (2018) Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports
Zhao Y, Cushing PR, Smithson DC, et al. (2018) Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports
Fitzpatrick JM, Pellegrini M, Cushing PR, et al. (2014) Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction. Biochemistry. 53: 5916-22
Amacher JF, Cushing PR, Brooks L, et al. (2014) Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses. Structure (London, England : 1993). 22: 82-93
Amacher JF, Cushing PR, Bahl CD, et al. (2013) Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop. The Journal of Biological Chemistry. 288: 5114-26
Kundu R, Cushing PR, Popp BV, et al. (2012) Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR. Angewandte Chemie (International Ed. in English). 51: 7217-20
Roberts KE, Cushing PR, Boisguerin P, et al. (2012) Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity. Plos Computational Biology. 8: e1002477
Amacher JF, Cushing PR, Weiner JA, et al. (2011) Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 600-3
Roberts KE, Cushing PR, Boisguerin P, et al. (2011) Design of protein-protein interactions with a novel ensemble-based scoring algorithm Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 6577: 361-376
Cushing PR, Vouilleme L, Pellegrini M, et al. (2010) A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR. Angewandte Chemie (International Ed. in English). 49: 9907-11
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