Patrick R. Cushing, Ph.D.
Affiliations: | 2011 | Biochemistry | Dartmouth College, Hanover, NH, United States |
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BiochemistryGoogle:
"Patrick Cushing"Parents
Sign in to add mentor| Dean R. Madden | grad student | 2011 | Dartmouth | |
| (From Target Discovery to High-Throughput Sereens--Selective CAL PDZ Inhihitors as Candidate CF Therapeutics.) | ||||
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Publications
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| Zhao Y, Cushing PR, Smithson DC, et al. (2018) Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports |
| Zhao Y, Cushing PR, Smithson DC, et al. (2018) Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports |
| Fitzpatrick JM, Pellegrini M, Cushing PR, et al. (2014) Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction. Biochemistry. 53: 5916-22 |
| Amacher JF, Cushing PR, Brooks L, et al. (2014) Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses. Structure (London, England : 1993). 22: 82-93 |
| Amacher JF, Cushing PR, Bahl CD, et al. (2013) Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop. The Journal of Biological Chemistry. 288: 5114-26 |
| Kundu R, Cushing PR, Popp BV, et al. (2012) Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR. Angewandte Chemie (International Ed. in English). 51: 7217-20 |
| Roberts KE, Cushing PR, Boisguerin P, et al. (2012) Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity. Plos Computational Biology. 8: e1002477 |
| Amacher JF, Cushing PR, Weiner JA, et al. (2011) Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 600-3 |
| Roberts KE, Cushing PR, Boisguerin P, et al. (2011) Design of protein-protein interactions with a novel ensemble-based scoring algorithm Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 6577: 361-376 |
| Cushing PR, Vouilleme L, Pellegrini M, et al. (2010) A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR. Angewandte Chemie (International Ed. in English). 49: 9907-11 |