John G. Shelton, Ph.D.
Affiliations: | 2004 | East Carolina University, Greenville, NC, United States |
Area:
Molecular Biology, Cell BiologyGoogle:
"John Shelton"Parents
Sign in to add mentor| James A. McCubrey | grad student | 2004 | East Carolina University | |
| (A conditionally active v -ErbB transforms hematopoietic cells to cytokine -independence and promotes cell survival and proliferation.) | ||||
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Publications
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| Abrams SL, Steelman LS, Shelton JG, et al. (2010) The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell Cycle (Georgetown, Tex.). 9: 1781-91 |
| Abrams SL, Steelman LS, Shelton JG, et al. (2010) Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy. Cell Cycle (Georgetown, Tex.). 9: 1839-46 |
| Steelman LS, Abrams SL, Shelton JG, et al. (2010) Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle (Georgetown, Tex.). 9: 1629-38 |
| Bertrand FE, Steelman LS, Chappell WH, et al. (2006) Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells. Leukemia. 20: 1254-60 |
| Konopleva M, Shi Y, Steelman LS, et al. (2005) Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells. Cancer Research. 65: 9962-70 |
| Shelton JG, Steelman LS, Abrams SL, et al. (2005) The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert Opinion On Therapeutic Targets. 9: 1009-30 |
| Shelton JG, Steelman LS, Abrams SL, et al. (2005) Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell Cycle (Georgetown, Tex.). 4: 822-30 |
| Shelton JG, Steelman LS, Abrams SL, et al. (2005) Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line. Cell Cycle (Georgetown, Tex.). 4: 818-21 |
| Calfee MW, Shelton JG, McCubrey JA, et al. (2005) Solubility and bioactivity of the Pseudomonas quinolone signal are increased by a Pseudomonas aeruginosa-produced surfactant. Infection and Immunity. 73: 878-82 |
| Bertrand FE, Spengemen JD, Shelton JG, et al. (2005) Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support. Leukemia. 19: 98-102 |