Johanna C. Sierra, Ph.D.

Affiliations: 
2010 University of Texas Medical Branch, Galveston, TX 
Area:
Microbiology Biology
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"Johanna Sierra"

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Ashok K. Chopra grad student 2010 UTMB
 (Mechanism of action of AexU, a new type III secretion system effector from an emerging human pathogen Aeromonas hydrophila.)
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Publications

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Sierra JC, Suarez G, Piazuelo MB, et al. (2019) α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in . Proceedings of the National Academy of Sciences of the United States of America
Suarez G, Romero-Gallo J, Piazuelo MB, et al. (2019) Nod1 imprints inflammatory and carcinogenic responses toward the gastric pathogen Helicobacter pylori. Cancer Research
Sierra JC, Asim M, Verriere TG, et al. (2017) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut
Suarez G, Romero-Gallo J, Sierra JC, et al. (2017) Genetic manipulation of Helicobacter pylori virulence function by host carcinogenic phenotypes. Cancer Research
Varga MG, Shaffer CL, Sierra JC, et al. (2016) Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene
Murray-Stewart T, Sierra JC, Piazuelo MB, et al. (2016) Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer Oncogene
Chaturvedi R, de Sablet T, Asim M, et al. (2015) Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene. 34: 3429-40
Chaturvedi R, Asim M, Piazuelo MB, et al. (2014) Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology. 146: 1739-51.e14
Sierra JC, Hobbs S, Chaturvedi R, et al. (2013) Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G196-203
Noto JM, Khizanishvili T, Chaturvedi R, et al. (2013) Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. Plos One. 8: e54344
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