Melanie Mediavilla-Varela, Ph.D.

Affiliations: 
2009 Loma Linda University, Loma Linda, United States 
Area:
Microbiology Biology, Genetics, Cell Biology
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"Melanie Mediavilla-Varela"

Parents

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Carlos A. Casiano grad student 2009 Loma Linda University
 (Contribution of LEDGF/p75 to prostate cancer chemoresistance.)
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Publications

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Mediavilla-Varela M, Boateng K, Noyes D, et al. (2016) The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. Bmc Cancer. 16: 176
Basu A, Cajigas-Du Ross CK, Rios-Colon L, et al. (2016) LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. Plos One. 11: e0146549
Soliman H, Mediavilla-Varela M, Antonia SJ. (2015) A GM-CSF and CD40L bystander vaccine is effective in a murine breast cancer model. Breast Cancer (Dove Medical Press). 7: 389-97
Gordian E, Li J, Pevzner Y, et al. (2014) Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer. Plos One. 9: e114131
Chen L, Gibbons DL, Goswami S, et al. (2014) Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nature Communications. 5: 5241
Pacheco FJ, Almaguel FG, Evans W, et al. (2014) Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 63: 859-71
Mediavilla-Varela M, Luddy K, Noyes D, et al. (2013) Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biology & Therapy. 14: 860-8
Soliman H, Mediavilla-Varela M, Antonia S. (2010) Indoleamine 2,3-dioxygenase: is it an immune suppressor? Cancer Journal (Sudbury, Mass.). 16: 354-9
Mediavilla-Varela M, Pacheco FJ, Almaguel F, et al. (2009) Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75. Molecular Cancer. 8: 68
Brown-Bryan TA, Leoh LS, Ganapathy V, et al. (2008) Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Molecular Cancer Research : McR. 6: 1293-307
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