Ravikiran Raju, Ph.D.

Affiliations: 
2012 Biological Sciences in Public Health Harvard University, Cambridge, MA, United States 
Area:
Molecular Biology, Microbiology Biology
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"Ravikiran Raju"

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Eric J. Rubin grad student 2012 Harvard
 (Where proteins go to die: Elucidating the physiological and therapeutic significance of the Clp protease complex in Mycobacterium tuberculosis.)
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Publications

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Lehmann J, Cheng TY, Aggarwal A, et al. (2017) An antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis. Angewandte Chemie (International Ed. in English)
Marakalala MJ, Raju RM, Sharma K, et al. (2016) Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nature Medicine
Raju RM, Raju SM, Zhao Y, et al. (2016) Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease. Emerging Infectious Diseases. 22: 365-9
Moreira W, Ngan GJ, Low JL, et al. (2015) Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria. Mbio. 6: e00253-15
Raju RM, Jedrychowski MP, Wei JR, et al. (2014) Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. Plos Pathogens. 10: e1003994
Raju RM, Goldberg AL, Rubin EJ. (2012) Bacterial proteolytic complexes as therapeutic targets. Nature Reviews. Drug Discovery. 11: 777-89
Raju RM, Unnikrishnan M, Rubin DH, et al. (2012) Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. Plos Pathogens. 8: e1002511
Akopian T, Kandror O, Raju RM, et al. (2012) The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. The Embo Journal. 31: 1529-41
La Rosa V, Poce G, Canseco JO, et al. (2012) MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrobial Agents and Chemotherapy. 56: 324-31
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