Jiachi Chiou, Ph.D.

Affiliations: 
2011 Graduate School - New Brunswick Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Molecular Biology, Biochemistry, Food Science and Technology Agriculture
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"Jiachi Chiou"

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Nilgun E. Tumer grad student 2011 Rutgers, New Brunswick
 (The role of the ribosomal stalk in the activity of ricin, Shiga-like toxin 1 and Shiga-like toxin 2 in Saccharomyces cerevisiae.)
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Publications

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He D, Chiou J, Zeng Z, et al. (2015) Residues distal to the active site contribute to enhanced catalytic activity of variant and hybrid β-lactamases derived from CTX-M-14 and -15. Antimicrobial Agents and Chemotherapy
Chiou J, Wan S, Chan KF, et al. (2015) Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1). Chemical Communications (Cambridge, England). 51: 9543-6
Wang Y, Chan FY, Sun N, et al. (2014) Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors. Chemical Biology & Drug Design. 84: 685-96
Chiou JC, Li XP, Remacha M, et al. (2011) Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2. The International Journal of Biochemistry & Cell Biology. 43: 1792-801
Pierce M, Kahn JN, Chiou J, et al. (2011) Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model. Rna (New York, N.Y.). 17: 201-10
Li XP, Chiou JC, Remacha M, et al. (2009) A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes. Biochemistry. 48: 3853-63
Chiou JC, Li XP, Remacha M, et al. (2008) The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae. Molecular Microbiology. 70: 1441-52
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