Matthias Gotte

Affiliations: 
Department of Microbiology & Immunology McGill University, Montreal, QC, Canada 
Area:
Immunology, Virology Biology
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"Matthias Gotte"
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Publications

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Gordon CJ, Lee HW, Tchesnokov EP, et al. (2021) Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir. The Journal of Biological Chemistry. 101529
Maheden K, Todd B, Gordon CJ, et al. (2021) Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs. The Enzymes. 49: 315-354
Götte M. (2021) Remdesivir for the treatment of Covid-19: the value of biochemical studies. Current Opinion in Virology. 49: 81-85
Gordon CJ, Tchesnokov EP, Schinazi RF, et al. (2021) Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. The Journal of Biological Chemistry. 100770
Todd B, Tchesnokov EP, Götte M. (2021) The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor. The Journal of Biological Chemistry. 100486
Tchesnokov EP, Gordon CJ, Woolner E, et al. (2020) Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action. The Journal of Biological Chemistry
Gordon CJ, Tchesnokov EP, Woolner E, et al. (2020) Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. The Journal of Biological Chemistry
Gordon CJ, Tchesnokov EP, Feng JY, et al. (2020) The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. The Journal of Biological Chemistry
Ablenas C, Gidi Y, Powdrill M, et al. (2019) Hepatitis C virus helicase binding and activity monitored through site-specific labeling using an expanded genetic code. Acs Infectious Diseases
Tchesnokov EP, Feng JY, Porter DP, et al. (2019) Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir. Viruses. 11
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