Matthias Gotte
Affiliations: | Department of Microbiology & Immunology | McGill University, Montreal, QC, Canada |
Area:
Immunology, Virology BiologyGoogle:
"Matthias Gotte"
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Publications
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| Lovell TC, Dewling HAF, Li CX, et al. (2025) Single-molecule assay reveals the impact of composition, RNA duplex, and inhibitors on the binding dynamics of SARS-CoV-2 polymerase complex. Biorxiv : the Preprint Server For Biology |
| Rodriguez L, Lee HW, Li J, et al. (2024) SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants. Antimicrobial Agents and Chemotherapy. e0123824 |
| Gordon CJ, Walker SM, Tchesnokov EP, et al. (2024) Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses. The Journal of Biological Chemistry. 107514 |
| Baldwin ET, van Eeuwen T, Hoyos D, et al. (2023) Structures, functions, and adaptations of the human LINE-1 ORF2 protein. Nature |
| Gidi Y, Robert A, Tordo A, et al. (2023) Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3' Terminus. Acs Infectious Diseases |
| Malone BF, Perry JK, Olinares PDB, et al. (2023) Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature |
| Feng JY, Du Pont V, Babusis D, et al. (2022) The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2. Molecules (Basel, Switzerland). 27 |
| Stevens LJ, Pruijssers AJ, Lee HW, et al. (2022) Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. Science Translational Medicine. eabo0718 |
| Bader CD, Panter F, Garcia R, et al. (2022) Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium. Chemistry (Weinheim An Der Bergstrasse, Germany). 28: e202104484 |
| Gordon CJ, Lee HW, Tchesnokov EP, et al. (2021) Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir. The Journal of Biological Chemistry. 101529 |