Melanie Higgins, Ph.D.
Affiliations: | 2012 | University of Victoria, Victoria, British Columbia, Canada |
Area:
Microbiology Biology, Molecular BiologyGoogle:
"Melanie Higgins"Parents
Sign in to add mentorAlisdair B. Boraston | grad student | 2012 | University of Victoria | |
(Fucose Utilization in Streptococcus pneumoniae.) |
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Publications
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Higgins MA, Tegl G, MacDonald SS, et al. (2021) N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes. Acs Chemical Biology |
Higgins MA, Hamilton AM, Boraston AB. (2017) Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization. Proteins |
Robb M, Robb CS, Higgins MA, et al. (2015) A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. The Journal of Biological Chemistry |
Kwan DH, Constantinescu I, Chapanian R, et al. (2015) Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society. 137: 5695-705 |
Singh AK, Pluvinage B, Higgins MA, et al. (2014) Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA. Plos Pathogens. 10: e1004364 |
Higgins MA, Suits MD, Marsters C, et al. (2014) Structural and functional analysis of fucose-processing enzymes from Streptococcus pneumoniae. Journal of Molecular Biology. 426: 1469-82 |
Higgins MA, Boraston AB. (2011) Structure of the fucose mutarotase from Streptococcus pneumoniae in complex with L-fucose. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1524-30 |
Pluvinage B, Higgins MA, Abbott DW, et al. (2011) Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis. Structure (London, England : 1993). 19: 1603-14 |
Higgins MA, Ficko-Blean E, Meloncelli PJ, et al. (2011) The overall architecture and receptor binding of pneumococcal carbohydrate-antigen-hydrolyzing enzymes. Journal of Molecular Biology. 411: 1017-36 |
Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, et al. (2011) The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (London, England : 1993). 19: 640-51 |