Jason P. Gigley, Ph.D.

2007 Immunology and Microbiology Dartmouth College, Hanover, NH, United States 
Microbiology Biology, Parasitology Biology
"Jason Gigley"


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David J. Bzik grad student 2007 Dartmouth
 (Host immune responses in a non replication model of Toxoplasma gondii infection.)


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David W Donley grad student 2013- University of Wyoming (Neurotree)
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Donley DW, Olson AR, Raisbeck MF, et al. (2016) Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality. Plos One. 11: e0162404
Gigley JP. (2016) The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection. Plos Pathogens. 12: e1005396
Ivanova D, Krempels R, Ryfe J, et al. (2014) NK cells in mucosal defense against infection. Biomed Research International. 2014: 413982
Gigley JP, Bhadra R, Moretto MM, et al. (2012) T cell exhaustion in protozoan disease. Trends in Parasitology. 28: 377-84
Bhadra R, Gigley JP, Khan IA. (2012) PD-1-mediated attrition of polyfunctional memory CD8+ T cells in chronic toxoplasma infection. The Journal of Infectious Diseases. 206: 125-34
Bhadra R, Gigley JP, Khan IA. (2011) Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 4421-5
Gigley JP, Khan IA. (2011) Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection. Plos One. 6: e20838
Gigley JP, Bhadra R, Khan IA. (2011) CD8 T Cells and Toxoplasma gondii: A New Paradigm. Journal of Parasitology Research. 2011: 243796
Bhadra R, Gigley JP, Khan IA. (2011) The CD8 T-cell road to immunotherapy of toxoplasmosis. Immunotherapy. 3: 789-801
Bhadra R, Gigley JP, Weiss LM, et al. (2011) Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade. Proceedings of the National Academy of Sciences of the United States of America. 108: 9196-201
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