Jason C. Choi, Ph.D.

Affiliations: 
2007 Roswell Park - Microbiology and Immunology State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Immunology, Molecular Biology
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"Jason Choi"

Parents

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Howard J Worman grad student Thomas Jefferson (Cell Biology Tree)
Shawn P. Murphy grad student 2007 SUNY Buffalo
 (Regulation of interferon-gamma signal transduction in human and mouse trophoblast cells.)
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Publications

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Choi JC, Wu W, Phillips E, et al. (2018) Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival. Human Molecular Genetics
Choi JC, Worman HJ. (2014) Nuclear envelope regulation of signaling cascades. Advances in Experimental Medicine and Biology. 773: 187-206
Muchir A, Kim YJ, Reilly SA, et al. (2013) Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation. Skeletal Muscle. 3: 17
Choi JC, Worman HJ. (2013) Reactivation of autophagy ameliorates LMNA cardiomyopathy. Autophagy. 9: 110-1
Choi JC, Wu W, Muchir A, et al. (2012) Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. The Journal of Biological Chemistry. 287: 40513-24
Wang Y, Ostlund C, Choi JC, et al. (2012) Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins. Nucleus (Austin, Tex.). 3: 452-62
Choi JC, Muchir A, Wu W, et al. (2012) Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Science Translational Medicine. 4: 144ra102
Muchir A, Wu W, Choi JC, et al. (2012) Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. Human Molecular Genetics. 21: 4325-33
Ostlund C, Folker ES, Choi JC, et al. (2009) Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. Journal of Cell Science. 122: 4099-108
Choi JC, Holtz R, Murphy SP. (2009) Histone deacetylases inhibit IFN-gamma-inducible gene expression in mouse trophoblast cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 6307-15
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